Gonococcal Arthritis: A Study of 202 Patients Treated With Penicillin, Sulfonamides or Fever Therapy

Robinson, Jay A.; Hirsh, Harold L.; Zeller, William W.; Dowling, Harry F.

doi:10.7326/0003-4819-30-6-1212

Cited by 7 publications

(1 citation statement)

References 11 publications

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“…Culturing of N. gonorrhoeae strain NCCP11945 at 41 °C could not be sustained (data not shown); however, the bacteria were able to adapt to and thrive at 39 °C. This suggests that N. gonorrhoeae is able to survive fevers, such as those associated with gonococcal arthritis; however, a lack of prolonged growth at 41 °C is likely the origin of reported success with artificial fever therapy treatments in the past [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating Potential Chromosomal Rearrangements during Laboratory Culture of Neisseria gonorrhoeae

et al. 2018

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Comparisons of genome sequence data between different strains and isolates of Neisseria spp., such as Neisseria gonorrhoeae, reveal that over the evolutionary history of these organisms, large scale chromosomal rearrangements have occurred. Factors within the genomes, such as repetitive sequences and prophage, are believed to have contributed to these observations. However, the timescale in which rearrangements occur is not clear, nor whether it might be expected for them to happen in the laboratory. In this study, N. gonorrhoeae was repeatedly passaged in the laboratory and assessed for large scale chromosomal rearrangements. Using gonococcal strain NCCP11945, for which there is a complete genome sequence, cultures were passaged for eight weeks in the laboratory. The resulting genomic DNA was assessed using Pulsed Field Gel Electrophoresis, comparing the results to the predicted results from the genome sequence data. Three cultures generated Pulsed Field Gel Electrophoresis patterns that varied from the genomic data and were further investigated for potential chromosomal rearrangements.

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Section: Discussionmentioning

confidence: 99%

Investigating Potential Chromosomal Rearrangements during Laboratory Culture of Neisseria gonorrhoeae

et al. 2018

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Sex incidence of gonococcal arthritis

Graber

Sanford

Ziff

1960

Arthritis & Rheumatism

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Of 48 cases of gonococcal arthritis seen between 1952 and 1958, 10, or 22 per cent, were males. The low incidence observed in males is in distinct contrast to the high incidence in this group reported prior to the antibiotic era. It is suggested that this change in sex incidence is the result of prompt treatment of the preceding symptomatic primary gonorrhea in the heterosexual male, whereas primary gonorrhea in the female is often unrecognized.

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Die Klinik der Gonorrhoe des Mannes. Die hämatogenen Komplikationen der Gonorrhoe

Burckhardt

1963

Geschlechtskrankheiten

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Gonococcal Arthritis: A Study of 202 Patients Treated With Penicillin, Sulfonamides or Fever Therapy

Cited by 7 publications

References 11 publications

Investigating Potential Chromosomal Rearrangements during Laboratory Culture of Neisseria gonorrhoeae

Investigating Potential Chromosomal Rearrangements during Laboratory Culture of Neisseria gonorrhoeae

Sex incidence of gonococcal arthritis

Die Klinik der Gonorrhoe des Mannes. Die hämatogenen Komplikationen der Gonorrhoe

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