Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision

Fuchs‐Buder, Thomas; Claudius, Casper; Skovgaard, L. T.; Eriksson, Lars; Mirakhur, R. K.; Viby‐Mogensen, J.

doi:10.1111/j.1399-6576.2007.01352.x

Cited by 582 publications

(636 citation statements)

References 59 publications

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“…Heart rate was also similar at baseline (85 [18] and 80 [15] beats Á min -1 , respectively). However, the lowest HR value recorded was less in the succinylcholine group compared with the rocuronium group (67 [12] vs. 74 [13] beats min -1 , respectively; P \ 0.001). In the succinylcholine group, 12 patients developed a decrease of MAP by more than 25% from baseline value for 60 s, necessitating the use of ephedrine, whereas in the rocuronium group, four patients required ephedrine (P = 0.067).…”

Section: Resultsmentioning

confidence: 85%

“…A 7.0-or 8.0-mm tracheal tube was used for females and males, respectively. Intubating conditions, based on a scoring system proposed for good clinical research practice, were evaluated using the following variables 12 : ease of laryngoscopy, vocal cord position, and reaction to insertion of the tracheal tube and cuff inflation (diaphragmatic movement-coughing). Each of these variables was rated as excellent, good, or poor.…”

Section: Methodsmentioning

confidence: 99%

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Excellent intubating conditions with remifentanil–propofol and either low-dose rocuronium or succinylcholine

Siddik-Sayyid

Taha

Kanazi

et al. 2009

Can J Anesth/J Can Anesth

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Purpose The shortest time to tracheal intubation, the best intubating conditions, and the shortest duration of muscle paralysis are achieved with succinylcholine. During a lidocaine-remifentanil-propofol induction of anesthesia, we compared intubating conditions 90 s after administering low-dose rocuronium (0.3 mg Á kg -1 ) with intubating conditions 60 s after administering succinylcholine 1.5 mg Á kg -1 . Methods The randomized double-blind study included 184 healthy adult patients scheduled for elective surgery. Anesthesia was induced in all patients with lidocaine 1.5 mg Á kg -1 , remifentanil 2 lg Á kg -1 , and propofol 2 mg Á kg -1 administered over 30 s. In one group, rocuronium 0.3 mg Á kg -1 was administered before the induction sequence, and in the other group, succinylcholine 1.5 mg Á kg -1 was administered after the induction sequence. Laryngoscopy was attempted 90 s after rocuronium administration and 60 s after succinylcholine administration. Intubating conditions were assessed as excellent, good, or poor on the basis of ease of laryngoscopy, position of the vocal cords, and reaction to insertion of the tracheal tube and cuff inflation. Results There were 92 patients per group. In the rocuronium group, intubating conditions were excellent in 83 patients (90%), good in 8 (9%), and poor in 1 (1%), not significantly different from the intubating conditions in the succinylcholine group, which were excellent in 88 patients (96%), good in 3 (3%), and poor in 1 (1%) (P = 0.3). Conclusion During a lidocaine-remifentanil-propofol induction of anesthesia, rocuronium 0.3 mg Á kg -1 administered before the induction sequence provides intubating conditions comparable to those achieved with succinylcholine 1.5 mg Á kg -1 administered after the induction sequence. RésuméObjectif La succinylcholine permet de re´aliser l'intubation trache´ale dans les plus courts de´lais, avec les meilleures conditions d'intubation et la dure´e la plus courte de paralysie musculaire. Au cours d'une induction de l'anesthe´sie avec lidocaı¨ne-re´mifentanil-propofol, nous avons compare´les conditions d'intubation 90 sec apre`s avoir administre´du rocuronium a`faible dose (0,3 mgÁkg -1 ) aux conditions d'intubation 60 sec apre`s avoir administre´de la succinylcholine a`1,5 mgÁkg -1 . Méthode Au total, 184 patients adultes sains devant subir une chirurgie non urgente ont pris part a`cette e´tude randomise´e en double aveugle. L'anesthe´sie a e´te´induite chez tous les patients avec de la lidocaı¨ne (1,5 mgÁkg -1 ), du re´mifentanil (2 lgÁkg -1 ) et du propofol (2 mgÁkg -1 ) administre´s sur une pe´riode de 30 sec. Dans un groupe, du rocuronium (0,3 mgÁkg -1 ) a éte´administre´avant la

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Section: Resultsmentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Excellent intubating conditions with remifentanil–propofol and either low-dose rocuronium or succinylcholine

Siddik-Sayyid

Taha

Kanazi

et al. 2009

Can J Anesth/J Can Anesth

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“…Exclusion criteria were: neuromuscular disease (muscular dystrophy, myasthenia gravis, myotonias or upper motor neurone lesions); renal or hepatic failure; a history of or predictors of difficult airway; hypermagnesaemia (> 1.02 mmol.l À1 ) or hypomagnesaemia (< 0.7 mmol.l À1 ); pregnancy or potential pregnancy; the use of drugs known to affect neuromuscular blockade; and allergy to drugs used in the study. The study followed the recommendations of Good Clinical Research Practice in Pharmacodynamic Studies of Neuromuscular Blocking Agents II: the Stockholm revision [13].…”

Section: Methodsmentioning

confidence: 99%

“…The transducer position was secured using a hand adapter (Hand Adapter â ; Organon Ltd), keeping the arm in the same position throughout the entire procedure. A temperature sensor was placed on the hypothenar region of the monitored hand [8,11,13].…”

Section: Methodsmentioning

confidence: 99%

Effect of magnesium sulphate on sugammadex reversal time for neuromuscular blockade: a randomised controlled study

et al. 2015

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SummaryMagnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium-induced blockade. The aim of this study was to determine the effect of pre-treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy-three patients were randomly assigned to receive magnesium sulphate (40 mg.kg À1 ) or saline intravenously. After anaesthetic induction, continuous train-of-four monitoring was performed and rocuronium was administered (0.6 mg.kg À1 ). When a second twitch appeared, the patients received sugammadex (2 mg.kg À1 ).

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“…Todos los métodos de medición cuantitativa del BNM han requerido de su validación comparándolo con la MMG. La AMG y la EMG están disponibles y son mucho más fáciles de usar en quirófano 37 . Debido a la potencial morbilidad asociada con bloqueos neuromusculares residuales, la monitorización perioperatoria (cualquiera que sea el método empleado) de la función neuromuscular es esencial.…”

Section: Monitorización Neuromuscularunclassified

Monitorización intraoperatoria del bloqueo neuromuscular y la presión arterial con un solo dispositivo (TOF-Cuff): estudio comparativo con la mecanomiografía y la presión arterial invasiva

Ruiz

Cayuela

Montes

et al. 2017

Revista Española de Anestesiología y Reanimación

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Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision

Cited by 582 publications

References 59 publications

Excellent intubating conditions with remifentanil–propofol and either low-dose rocuronium or succinylcholine

Excellent intubating conditions with remifentanil–propofol and either low-dose rocuronium or succinylcholine

Effect of magnesium sulphate on sugammadex reversal time for neuromuscular blockade: a randomised controlled study

Monitorización intraoperatoria del bloqueo neuromuscular y la presión arterial con un solo dispositivo (TOF-Cuff): estudio comparativo con la mecanomiografía y la presión arterial invasiva

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