The presented paper describes the ReSCUDE project, developed by the Department of Civil, Environmental, Land, Construction and Chemistry (DICATECh) of the Polytechnic University of Bari under the grant Attraction and International Mobility, of the Italian Ministry of Education, University and Research. The project focuses on the evaluation of the effects of Slow-Onset Disasters (SODs), and Rapid Onset Disasters (RODs) on historic town centres. To this end, an integrated approach based on innovative geomatics, building techniques and advanced behavioural models, is being applied to the old town built area of Ascoli Satriano (FG) and Molfetta (BA) in the Apulia Region (Italy). Over the next three years, the ResCUDE project will allow to perform in-depth analyses on the historic built environment of the identified case studies, fostering the processes of its knowledge, assessment, control, management and design, in connection to the risks deriving from ROD and SOD events. The expected outputs will be useful to define possible scenarios for civil defence purposes and undertake actions aimed at risk mitigation.