Gorilla class I major histocompatibility complex alleles: comparison to human and chimpanzee class I.

Lawlor, David A.; Warren, Ean; Taylor, Patricia M.; Parham, Peter

doi:10.1084/jem.174.6.1491

Cited by 101 publications

(98 citation statements)

References 36 publications

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“…Likewise, an analysis of complete cDNA sequences of 14 HLA-C alleles revealed that HLA-C alleles divide into two groups, one comprising the Cw7 sero-type, and the other group including all remaining alleles. 19 These and other studies have sought to elucidate the sequence relationships of a subset of HLA class I alleles by parsimony or distance-based phylogenetic methods. 20,21 The extensive polymorphism in HLA class I genes is thought to increase the repertoire of immune responses which an individual can mount.…”

Section: Correspondence: Stephen J O'brien Phd Laboratory Of Genomimentioning

confidence: 99%

“…Sequence analysis suggests HLA-C is more closely related to HLA-B than HLA-A and indicates the HLA-C locus may have arisen as a duplication of HLA-B. 24 HLA-C homologues have been identified in the chimp 30,31 and gorilla 19 but are not found in genome or transcript searches of Asian apes (Old World primates, orangutans, gibbons or rhesus monkeys). The suspected recent origin of the HLA-C locus may explain the more conservative nature of the phylogenetic analyses presented here.…”

Section: Hla-cmentioning

confidence: 99%

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Taxonomic hierarchy of HLA class I allele sequences

et al. 1999

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The markedly high levels of polymorphism present in classical class I loci of the human major histocompatibility complex have been implicated in infectious and immune disease recognition. The large numbers of alleles present at these loci have, however, limited efforts to verify associations between individual alleles and specific diseases. As an approach to reduce allele diversity to hierarchical evolutionarily related groups, we performed phylogenetic analyses of available HLA-A, B and C allele complete sequences (n = 216 alleles) using different approaches (maximum parsimony, distance-based minimum evolution and maximum likelihood). Full nucleotide and amino acid sequences were considered as well as abridged sequences from the hypervariable peptide binding region, known to interact in vivo, with HLA presented foreign peptide. The consensus analyses revealed robust clusters of 36 HLA-C alleles concordant for full and PBR sequence analyses. HLA-A alleles (n = 60) assorted into 12 groups based on full nucleotide and amino acid sequence which with few exceptions recapitulated serological groupings, however the patterns were largely discordant with clusters prescribed by PBR sequences. HLA-B which has the most alleles (n = 120) and which unlike HLA-A and -C is thought to be subject to frequent recombinational exchange, showed limited phylogenetic structure consistent with recent selection driven retention of maximum heterozygosity and population diversity. Those allele categories recognized offer an explicit phylogenetic criterion for grouping alleles potentially relevant for epidemiologic associations, for inferring the origin of MHC genome organization, and for comparing functional constraints in peptide presentation of HLA alleles.

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Section: Correspondence: Stephen J O'brien Phd Laboratory Of Genomimentioning

confidence: 99%

Section: Hla-cmentioning

confidence: 99%

Taxonomic hierarchy of HLA class I allele sequences

et al. 1999

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“…In addition, both HLA-C variants are present in gorilla (Lawlor et al 1991) and bonobo (Cooper et al 1998). One might expect gibbons (the lesser apes) to be intermediate between Old World monkeys and the great apes, but a recent study (Abi-Rached et al 2010a) has shown that their MHC class I ligands to have pursued quite a different course of evolution.…”

Section: Hla-c Ligands and Kirs In Non-human Primatesmentioning

confidence: 99%

Comparative studies of placentation and immunology in non-human primates suggest a scenario for the evolution of deep trophoblast invasion and an explanation for human pregnancy disorders

Carter

2011

Reproduction

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Deep trophoblast invasion in the placental bed has been considered the hallmark of human pregnancy. It occurs by two routes, interstitial and endovascular, and results in transformation of the walls of the spiral arteries as they traverse the decidua and the inner third of the myometrium. Disturbances in this process are associated with reproductive disorders such preeclampsia. In contrast, trophoblast invasion in Old World monkeys occurs only by the endovascular route and seldom reaches the myometrium. Recently, it was shown that this pattern is maintained in gibbons, but that the human arrangement also occurs in chimpanzee and gorilla. There is an interesting parallel with results from placental immunology regarding the evolution of the major histocompatability complex class I antigen HLA-C and its cognate receptors. HLA-C is not present in Old World monkeys or gibbons. It emerged in the orangutan and became polymorphic in the lineage leading to gorilla, bonobo, chimpanzee, and human. Interaction between HLA-C1 and HLA-C2 on the surface of trophoblast and killer immunoglobulin-like receptors (KIRs) expressed by uterine natural killer cells are important regulators of trophoblast invasion. Evolution of this system in great apes may have been one prerequisite for deep trophoblast invasion but seems to have come at a price. The evidence now suggests that certain combinations of maternal genotype for KIRs and fetal genotype for HLA-C imply an increased risk of preeclampsia, fetal growth restriction, and recurrent abortion. The fetal genotype is in part derived from the father providing an explanation for the paternal contribution to reproductive disorders.

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“…Rhesus macaques express orthologues of the classical HLA-A and -B genes, but not orthologues of HLA-C (8). Orthologues of HLA-C have been identified in chimpanzees, gorillas, and orangutans (2,24,25), but not in Old World monkeys (1). Hence, the HLA-C locus appears to represent a recent duplication of the HLA-B locus that occurred after the divergence of apes from Old World monkeys (1,8,15).…”

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confidence: 99%

Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2

DeGottardi¹,

Specht

Metcalf

et al. 2008

J Virol

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Human immunodeficiency virus type 1 (HIV-1) Nef downregulates HLA-A and -B molecules, but not HLA-C or -E molecules, based on amino acid differences in their cytoplasmic domains to simultaneously evade cytotoxic T lymphocyte (CTL) and natural killer cell surveillance. Rhesus macaques and sooty mangabeys express orthologues of HLA-A, -B, and -E, but not HLA-C, and many of these molecules have unique amino acid differences in their cytoplasmic tails. We found that these differences also resulted in differential downregulation by primary simian immunodeficiency virus (SIV) SIV smm/mac and HIV-2 Nef alleles. Thus, selective major histocompatibility complex class I downregulation is a conserved mechanism of immune evasion for pathogenic SIV infection of rhesus macaques and nonpathogenic SIV infection of sooty mangabeys.

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Gorilla class I major histocompatibility complex alleles: comparison to human and chimpanzee class I.

Cited by 101 publications

References 36 publications

Taxonomic hierarchy of HLA class I allele sequences

Taxonomic hierarchy of HLA class I allele sequences

Comparative studies of placentation and immunology in non-human primates suggest a scenario for the evolution of deep trophoblast invasion and an explanation for human pregnancy disorders

Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2

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