Goshajinkigan reduces oxaliplatin-induced peripheral neuropathy without affecting anti-tumour efficacy in rodents

Ushio, Soichiro; Egashira, Nobuaki; Sada, Haruki; Kawashiri, Takehiro; Shirahama, Masafumi; Masuguchi, Ken; Oishi, Ryozo

doi:10.1016/j.ejca.2011.08.009

Cited by 79 publications

(62 citation statements)

References 27 publications

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“…For instance, one of the components of GJG, Poria (Wolfiporia extensa), has shown an antiemetic effect through 5-HT3A receptor inhibition [55]. About the safety of GJG, a recent phase 2, randomized, double-blind, placebo-controlled study concluded that GJG offers an acceptable safety margin and a promising effect in delaying the onset of grade 2 or greater oxaliplatin-induced peripheral neurotoxicity without impairing chemotherapy efficacy [48], confirming previous animal models findings [56]. To date, there are no strong recommendations about the use of specific neuroprotective agents and also the effectiveness of herbal medicines, such as GJG must be better elucidated [57][58][59].…”

supporting

confidence: 56%

Pharmacological Approaches and Natural Products for Prevention of Chemotherapy-Induced Peripheral Neuropathy - A Review

Cascella

Muzio

2017

IJPPE

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Abstract. Chemotherapy-induced peripheral neuropathy (CIPN) is a one of the most common and severe cancer treatment-related adverse effect. It can often cause the stop of the treatment and affects the long-term quality of life of cancer survivors. Unfortunately, there are no effective agent or protocol to prevent with strong evidence of effectiveness this toxicity prevention of CIPN. Thus, CIPN prevention mainly consists of cumulative dose-reduction or lower dose-intensities, especially in higher risk patients. After a brief description of pathophysiology and features of CIPN, the purpose of this study is to analyse the role of standard pharmacological approaches and natural products for prevention of this serious side effect.

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supporting

confidence: 56%

Pharmacological Approaches and Natural Products for Prevention of Chemotherapy-Induced Peripheral Neuropathy - A Review

Cascella

Muzio

2017

IJPPE

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“…The effect of GJG against cumulative oxaliplatin-induced neuropathy was indicated, but the efficacy of GJG against acute neuropathy remains unproved. On the other hand, a basic study of a rodent model of oxaliplatininduced neuropathy also demonstrated that GJG ameliorated oxaliplatin-induced neuropathy and notably relieved the cold hypersensitivity caused by oxaliplatin (18). However, the mechanism of how GJG prevents oxaliplatininduced acute neuropathy remains uncertain.…”

Section: Introductionmentioning

confidence: 98%

Goshajinkigan, a Traditional Japanese Medicine, Prevents Oxaliplatin-Induced Acute Peripheral Neuropathy by Suppressing Functional Alteration of TRP Channels in Rat

et al. 2014

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Abstract. The acute peripheral neuropathy induced by oxaliplatin treatment occurs very frequently and is aggravated by exposure to cold. Goshajinkigan (GJG), a traditional Japanese (kampo) medicine, was recently shown to be effective against oxaliplatin-induced acute neuropathy. However, because the effects of GJG and its mechanism in relation to those of its ingredients and its mechanism are not well understood, we examined the effects of GJG on acute neuropathy. Further, we investigated whether GJG affects the functions and gene expressions of transient receptor potential (TRP) channels using a rat model of oxaliplatin-induced neuropathy. Administration of oxaliplatin increased withdrawal responses from cold stimulation, and GJG or calcium gluconate/ magnesium sulfate significantly inhibited the oxaliplatin-induced cold hypersensitivity. Application of menthol, a TRPA1/TRPM8 agonist, or allyl isothiocyanate (AITC), a selective TRPA1 agonist, to the hind paw of oxaliplatin-treated rats enhanced the nocifensive behaviors evoked by each agonist, whereas oxaliplatin had no significant effect on nocifensive behaviors evoked by capsaicin, a TRPV1 agonist. GJG treatment reduced menthol-or AITC-evoked withdrawal responses potentiated by oxaliplatin. Furthermore, GJG suppressed the increase of TRPA1 and TRPM8 mRNA expression induced by oxaliplatin in dorsal root ganglia. These findings suggest that GJG prevented oxaliplatin-induced acute peripheral neuropathy by suppressing functional alteration of TRP channels, especially TRPA1 and TRPM8.

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“…Recently, the beneficial properties of Jesengsingi-Hwan on CIPN have been widely prospected. In a murine study, Ushino et al showed that Jesengsingi-Hwan can reduce CIPN without influence on anti-cancer potency [41]. Kono et al examined a preventive effect of Jesengsingi-Hwan on chronic oxaliplatin-induced hypoesthesia in rats.…”

Section: Jesengsingi-hwan (Goshajinkigan In Japanese)mentioning

confidence: 99%

“…Reduces peripheral neuropathy without influence on anti-cancer potency Ameliorates abnormal sensations and histological damage to the sciatic nerve [41,42] Paclitaxel in mice Inhibits mechanical allodynia [43] Oxaliplatin in a placebo-controlled double-blind randomized study Delays onset of grade 2 or greater peripheral neurotoxicity without impairing FOLFOX efficacy with an acceptable safety margin [44,45] Prevents exacerbation of peripheral neuropathy [46,47] A clinical trial enrolling 82 patients Reduces peripheral neuropathy [48] …”

Section: Oxaliplatin In Ratsmentioning

confidence: 99%

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

Lee

Kim

2016

Molecules

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Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent adverse effect of neurotoxic anticancer medicines. It leads to autonomic and somatic system dysfunction and decreases the patient's quality of life. This side effect eventually causes chemotherapy non-compliance. Patients are prompted to seek alternative treatment options since there is no conventional remedy for CIPN. A range of medicinal herbs have multifarious effects, and they have shown some evidence of efficacy in various neurological and immunological diseases. While CIPN has multiple mechanisms of neurotoxicity, these phytomedicines might offer neuronal protection or regeneration with the multiple targets in CIPN. Thus far, researchers have investigated the therapeutic benefits of several herbs, herbal formulas, and phytochemicals in preventing the onset and progress of CIPN in animals and humans. Here, we summarize current knowledge regarding the role of phytochemicals, herb extracts, and herbal formulas in alleviating CIPN.

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Goshajinkigan reduces oxaliplatin-induced peripheral neuropathy without affecting anti-tumour efficacy in rodents

Cited by 79 publications

References 27 publications

Pharmacological Approaches and Natural Products for Prevention of Chemotherapy-Induced Peripheral Neuropathy - A Review

Pharmacological Approaches and Natural Products for Prevention of Chemotherapy-Induced Peripheral Neuropathy - A Review

Goshajinkigan, a Traditional Japanese Medicine, Prevents Oxaliplatin-Induced Acute Peripheral Neuropathy by Suppressing Functional Alteration of TRP Channels in Rat

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

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