Gout and Quality of Life: Table 1.

Kim, Seo Young; Choi, Hyon K.

doi:10.3899/jrheum.090034

Cited by 13 publications

(19 citation statements)

References 30 publications

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“…However, the findings also suggest potential value in developing a measure of functioning specific to gout and relevant to both patient groups that is less focused on the impact on upper extremities/fine motor skills and has greater focus on the lower extremities. The ability to effectively measure HRQoL is critical for assessing treatment benefit in terms of change over time and determining the best approach to managing gout [15]. …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the subsequent development of a conceptual model detailing the experience from the patient perspective could provide a starting point to aid selection of appropriate clinical study endpoints or guide the development of a new disease-specific measure. The ability to effectively measure HRQoL is crucial for evaluating the effects of the disease and treatment, as well as helping to better understand the best approach to managing gout [15]. …”

Section: Introductionmentioning

confidence: 99%

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What Outcomes are Important for Gout Patients? In-Depth Qualitative Research into the Gout Patient Experience to Determine Optimal Endpoints for Evaluating Therapeutic Interventions

Tatlock

Rüdell

Panter

et al. 2016

Patient

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Background and ObjectivesCharacterized by sudden onset of severe joint pain, swelling, redness, and tenderness to touch, gout ‘flare ups’ have a substantial impact on quality of life (QoL). This research employed a patient-centered approach to explore the symptoms and impacts of gout, and assess the content validity of existing patient-reported outcomes (PROs).MethodsQualitative interviews were conducted with 30 US gout patients (non-tophaceous: n = 20, tophaceous: n = 10) and five expert rheumatologists. Each interview included both concept elicitation (CE) questioning to learn about the patient experience and cognitive debriefing to assess the content validity of three PRO instruments (HAQ-DI, GAQ, and TIQ-20). Nine of the patients provided further real-time qualitative data through a smart phone application. All qualitative data were subject to thematic analysis using Atlas.ti. Two patient advisors and three expert clinicians were engaged as advisors at key stages throughout the research.ResultsInterview and real-time data identified the same core symptoms and proximal impact concepts. Severe pain (typically in joints of extremities) was described as the cardinal symptom, often accompanied by swelling, redness, heat, sensitivity to touch, and stiffness. Domains of QoL impacted included physical functioning, sleep, daily activities, and work. The PRO instruments were generally well-understood by patients, but each included items with questionable relevance to at least some of the sample, dependent on the specific joints affected.ConclusionsGout patients experience severe pain in affected joints, resulting in substantial limitations in physical functioning. Both the HAQ-DI and the TIQ-20 are useful for specific research purposes in the gout population, although modifications are recommended.Electronic supplementary materialThe online version of this article (doi:10.1007/s40271-016-0184-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

What Outcomes are Important for Gout Patients? In-Depth Qualitative Research into the Gout Patient Experience to Determine Optimal Endpoints for Evaluating Therapeutic Interventions

Tatlock

Rüdell

Panter

et al. 2016

Patient

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“…However, it is well known that gout is associated with several cardiovascular risk factors including hypertension, dyslipidaemia, insulin resistance, obesity, as well as renal failure [7]. Whether the impact of gout is related to the disease itself or whether it primarily arises from associated risk factors and medical conditions is still unclear [8]. …”

Section: Introductionmentioning

confidence: 99%

Gout impacts on function and health-related quality of life beyond associated risk factors and medical conditions: results from the KING observational study of the Italian Society for Rheumatology (SIR)

et al. 2013

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IntroductionGout is the most prevalent arthritis and significantly impacts on function and quality of life. Given that gout associates with disabling comorbid conditions, it is not clear whether such a complex of diseases accounts for the increased disability or if gout may play a role by itself. This study aims to evaluate the specific influence of gout and disease-related features on functional disability and health-related quality of life (HRQoL) in patients with gout followed in rheumatology clinics.MethodsA random sample of patients was drawn from clinical registries of 30 rheumatology clinics across Italy. Sociodemographic, general health and gout-specific variables were collected. Functional disability and HRQoL were assessed by the health assessment questionnaire (HAQ) and the Physical and Mental Component Summary scores (PCS and MCS) of the Short Form-36 (SF-36). Crude and adjusted ordinal logistic and linear regression models were applied to investigate the specific contribution of different variables on HAQ and SF-36 scores. Results are presented as odds ratio (OR) or mean difference (MD) and 95% confidence intervals.ResultsOut of 446 patients with gout, 90% were males with a mean age of 63.9 years and median disease duration of 3.8 years; the majority of patients were overweight or obese, and with several comorbidities; 21.1% showed at least moderate disability; the PCS score was significantly lower than expected age- and gender-matched samples in the general population, while MCS score was not. After adjusting for potential sociodemographic and general-health confounders, gout-specific variables significantly impacted on HAQ, including polyarticular involvement OR 3.82 (1.63, 8.95), presence of tophi OR 1.92 (1.07, 3.43) and recent attacks OR 2.20 (1.27, 3.81). Consistent results were found for PCS. The impairment of PCS compared to the general population was limited to patients with features of chronic gout. MCS was only affected by recent attacks (MD -2.72 [-4.58, -0.86]) and corticosteroid treatment (-3.39 [-5.30,-1.48]).ConclusionsThe data from the KING study confirm that gout impacts on disability and provide evidence for an independent association of gout and gout-related features with functional outcome and HRQoL. This result supports the need to improve specific treatment in gout.

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“…The decreased QOL is mainly in the physical component score [14][15][16] . This is exaggerated with the high number of patients with gout who also have other co-morbidities-typically cardiovascular and metabolic conditions.…”

Section: The Economics Of Goutmentioning

confidence: 99%

“…An important distinction that research points out is that the QOL value does not come from lowering sUA, but from clinical disease outcomes by treating gout flares with colchicine or NSAIDS 14,15 . Prevention of flares, as would be the case when using colchicine prophylactically, would further increase QOL by avoiding flares altogether.…”

Section: The Economics Of Goutmentioning

confidence: 99%