Gout in pediatric renal transplant recipients

Trück, Johannes; Laube, Guido F.; Vigier, Rodo O. von; Goetschel, Philippe

doi:10.1007/s00467-010-1599-6

Cited by 10 publications

(10 citation statements)

References 10 publications

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“…All patients with gout in our study were found to have at least one underlying disorder. Previous case reports have shown that gout in children or adolescents was associated with comorbidities such as Down syndrome [11], glycogen storage disease [12], renal transplantation [13], leukemia [14], and methyl malonic acidemia [15] (Table 2).…”

Section: Conditions Causing Hyperuricemiamentioning

confidence: 99%

“…Several drugs such as diuretics (thiazide), anticonvulsants (valproate and phenobarbital), cyclosporine, theophylline, and pyrazinamide have been reported to increase uric acid levels in children and adolescents [1, 13, 39–41]. Although the underlying causes are not fully understood, renal tubular reabsorption of uric acid, dehydration, and increased purine catabolism has been postulated [1, 42].…”

Section: Conditions Causing Hyperuricemiamentioning

confidence: 99%

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Hyperuricemia in Children and Adolescents: Present Knowledge and Future Directions

Kubota

2019

Journal of Nutrition and Metabolism

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Recent evidence suggests that hyperuricemia is an important condition in children and adolescents, particularly in association with noncommunicable diseases. This review aims to summarize our current understanding of this condition in pediatric patients. An analysis of serum uric acid reference values in a healthy population indicates that they increase gradually with age until adolescence, with differences between the sexes arising at about 12 years of age. This information should be taken into consideration when defining hyperuricemia in studies. Gout is extremely rare in children and adolescents, and most patients with gout have an underlying disease. The major causes of hyperuricemia are chronic conditions, including Down syndrome, metabolic or genetic disease, and congenital heart disease, and acute conditions, including gastroenteritis, bronchial asthma (hypoxia), malignant disorders, and drug side effects. The mechanisms underlying the associations between these diseases and hyperuricemia are discussed, together with recent genetic information. Obesity is a major cause of hyperuricemia in otherwise healthy children and adolescents. Obesity is often accompanied by metabolic syndrome; hyperuricemia in obese children and adolescents is associated with the components of metabolic syndrome and noncommunicable diseases, including hypertension, insulin resistance, dyslipidemia, and chronic kidney disease. Finally, strategies for the treatment of hyperuricemia, including lifestyle intervention and drug administration, are presented.

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Section: Conditions Causing Hyperuricemiamentioning

confidence: 99%

Section: Conditions Causing Hyperuricemiamentioning

confidence: 99%

Hyperuricemia in Children and Adolescents: Present Knowledge and Future Directions

Kubota

2019

Journal of Nutrition and Metabolism

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“…The risk of bone marrow depletion is increased in patients with low thiopurine methyl-transferase activity. To avoid the serious myelosuppression during treatment of hyperuricemia and gout, substantial reduction of azathioprine dose (by at least 50%) is required when allopurinol is given concomitantly, or alternative agents other than allopurinol should be considered [142][143][144].…”

Section: Treatment Of Hyperuricemiamentioning

confidence: 99%

Metabolic Drug Interactions with Immunosuppressants

Monostory¹

2018

Organ Donation and Transplantation - Current Status and Future Challenges

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Organ transplantation has become a routine clinical practice for patients with endstage disease of liver, kidney, heart, or lung. Although improved immunosuppressant therapy substantially contributes to the success of transplantation, clinicians continue to face challenges because of wide interindividual variations in blood concentrations resulting in subtherapeutic or supratherapeutic levels. Many undesired side-effects or therapeutic failure of immunosuppressants as a consequence are the results of differences or changes in drug metabolism. Considering genetic and nongenetic factors, such as co-medication, can refine the immunosuppressant therapy, facilitating personalized treatments to individual recipients. This review provides an up-to-date summary of functional polymorphisms of enzymes involved in the metabolism of immunosuppressants with low molecular weight and of the clinical significance of metabolic drug interactions between immunosuppressive agents and other drugs in therapeutic regimens of transplant recipients.

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“…Another study in China has shown a high prevalence of hyperuricemia in children of age 3-6 years, male gender, and a strong association with high diastolic blood pressure (DBP) and increased triglycerides concentration [ 5 ]. Hyperuricemia can occur as a side effect of several drugs like some antiepileptics, with valproate and phenobarbital being the commonest ones; thiazide diuretics, cyclosporine, theophylline, and pyrazinamide have also been reported as the main causative factors, with their mechanism not fully understood [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Causes of Hyperuricemia in Children

Kumar¹,

Gupta²,

Dev³

et al. 2021

Cureus

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IntroductionThere are various factors responsible for hyperuricemia in children, however, there is extremely limited local data available. In this study, we aim to determine the causes and risk factors associated with hyperuricemia. This study will assist pediatric consultants to identify children who might be at risk of hyperuricemia and manage them accordingly. MethodsThis study was conducted in pediatric outpatient departments of various tertiary care hospitals from January 2018 to December 2019. Five thousand (n = 5000) children of either gender between the age group of 1-14 years, were enrolled in the study after informed consent from their parents. Uric acid levels were assessed by using the UASure blood uric acid monitoring handheld device. ResultsIn our study, n = 1301 (26.02%) children had hyperuricemia. Hyperuricemia was more common in male compared to females (65.49% vs. 34.51%; p-value <0.00001) and in older children (9 ± 2 years vs. 7 ± 3; pvalue <0.00001). In hyperuricemia patients, the most common disorder was gastroenteritis (23.98%), followed by respiratory infection (23.14%) and asthma (15.45%). ConclusionHyperuricemia in children is very prevalent in the local setting. Patients with pre-existing conditions like congenital heart disease, asthma, epilepsy, and cancers should routinely be screened for hyperuricemia and managed accordingly to avoid long-term complications associated with hyperuricemia.

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Gout in pediatric renal transplant recipients

Cited by 10 publications

References 10 publications

Hyperuricemia in Children and Adolescents: Present Knowledge and Future Directions

Hyperuricemia in Children and Adolescents: Present Knowledge and Future Directions

Metabolic Drug Interactions with Immunosuppressants

Prevalence and Causes of Hyperuricemia in Children

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