GP178 Morphological features of chronic esophagitis in children with concomitant allergic diseases are interrelated with the level of cytokines and neuropeptides

Новикова, В. П.; Anichkov, N M; Nevskaia, Elena; Листопадова, А. П.; Zamiatina, Yulia; Гурина, О. П.; Варламова, Ольга Николаевна; Blinov, Aleksey

doi:10.1136/archdischild-2019-epa.239

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“…Subsequently, the relevant laboratory examinations can be performed for a comprehensive and detailed assessment of the child's condition, which was conducive to the choice of following treatment. The importance of monitoring for the positive rate of agerelated sIgE dynamically has been proposed due to the developmental stage of the immune function in infants (17). Therefore, combined with the results in this study, the sIgE detection of inhalation and ingestion allergens is required for infants, to potentially reduce the early or continuous exposure of these allergens.…”

Section: Discussionmentioning

confidence: 84%

Distribution of serum specific IgE in children with allergic conjunctivitis and analysis of its concomitant allergic diseases

Wang¹,

Du²,

Lu³

et al. 2020

Transl Pediatr

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Background: Allergic conjunctivitis (AC) is predominantly caused by serum specific-IgE (sIgE)-mediated type I allergy. This study aims to analyze the distribution of sIgE in children with AC, and the concomitant allergic diseases. Methods:The clinical data from 310 children, diagnosed with AC and admitted to our hospital from January 2017 to January 2019 were retrospectively collected. The children were divided into three groups: infant group (2 months to 1 year old, 91 cases), child group (1 to 3 years old, 112 cases), and preschool group (3 to 6 years old, 107 cases). Children in every group were analyzed for positive rates, the number of positive sIgE types, the distribution of positive inhaling and ingesting allergens and concomitant allergic diseases. Results:The sIgE positive rate of infant was significantly lower than that of the other two groups, and the number of 18.75% sIgE positive species was 1. The number of sIgE positive species in the child group and preschool group was more than 2 (78.30%, 71.15%). The positive rate of sIgE to dust mites, house dust, animal dander, eggs, beef, mutton and mango in the preschool group was significantly higher than the other groups (P<0.05). The positive rate of sIgE to milk in infant group was significantly higher than the other two groups (P<0.05). Children in the preschool group showed the highest incidence of AC, AC + allergic rhinitis, AC + allergic rhinitis + wheezing, while those in the infant group displayed the lowest incidence (P<0.05). AC + gastrointestinal allergy, AC + atopic dermatitis, AC + gastrointestinal allergy + atopic dermatitis in infant group was significantly higher than the other two groups (P<0.05). Patients in the child group displayed a significantly higher incidence of AC + infant wheezing than the other two groups (P<0.05). Conclusions:We correlated children's age with the positive rate and gradual increase in types of AC allergens. Concomitant allergic diseases of children with AC at different ages conform to the natural course of allergic diseases. In clinic, improving the diagnostic efficiency of AC in children, and early interventional treatment will positively contribute to their prognosis, and reduce the risk of other allergic diseases.

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Section: Discussionmentioning

confidence: 84%

Distribution of serum specific IgE in children with allergic conjunctivitis and analysis of its concomitant allergic diseases

Wang¹,

Du²,

Lu³

et al. 2020

Transl Pediatr

View full text Add to dashboard Cite

show abstract

GP178 Morphological features of chronic esophagitis in children with concomitant allergic diseases are interrelated with the level of cytokines and neuropeptides

Abstract: Conclusions Studies showed that in children with chronic gastritis, Epstein-Barr virus markers are detected in the blood with high frequency. There is a relationship between the presence of the Epstein-Barr virus in the gastric mucosa and histological signs of gastritis.

Cited by 1 publication

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Distribution of serum specific IgE in children with allergic conjunctivitis and analysis of its concomitant allergic diseases

Distribution of serum specific IgE in children with allergic conjunctivitis and analysis of its concomitant allergic diseases

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