Recently, self-healing hydrogel bioelectronic devices have raised enormous interest for their tissue-like mechanical compliance, desirable biocompatibility, and tunable adhesiveness on bioartificial organs. However, the practical applications of these hydrogel-based sensors are generally limited by their poor fulfillment of stretchability and sensitivity, brittleness under subzero temperature, and single sensory function. Inspired by the fiber-reinforced microstructures and mechano-transduction systems of human muscles, a self-healing (90.8%), long-lasting thermal tolerant and dual-sensory hydrogel-based sensor is proposed, with high gauge factor (18.28) within broad strain range (268.9%), low limit of detection (5% strain), satisfactory thermosensation (−0.016 °C–1), and highly discernible temperature resolution (2.7 °C). Especially by introducing a glycerol/water binary solvent system, desirable subzero-temperature self-healing performance, high water-retaining, and durable adhesion feature can be achieved, resulting from the ice crystallization inhibition and highly dynamic bonding. On account of the advantageous mechanoreception and thermosensitive capacities, a flexible touch keyboard for signature identification and a “fever indicator” for human forehead’s temperature detection can be realized by this hydrogel bioelectronic device.

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Non-syndromic cleft lip with palate (NSCLP) is the most serious sub-phenotype of non-syndromic orofacial clefts (NSOFC), which are the most common craniofacial birth defects in humans. Here we conduct a GWAS of NSCLP with multiple independent replications, totalling 7,404 NSOFC cases and 16,059 controls from several ethnicities, to identify new NSCLP risk loci, and explore the genetic heterogeneity between sub-phenotypes of NSOFC. We identify 41 SNPs within 26 loci that achieve genome-wide significance, 14 of which are novel (RAD54B, TMEM19, KRT18, WNT9B, GSC/DICER1, PTCH1, RPS26, OFCC1/TFAP2A, TAF1B, FGF10, MSX1, LINC00640, FGFR1 and SPRY1). These 26 loci collectively account for 10.94% of the heritability for NSCLP in Chinese population. We find evidence of genetic heterogeneity between the sub-phenotypes of NSOFC and among different populations. This study substantially increases the number of genetic susceptibility loci for NSCLP and provides important insights into the genetic aetiology of this common craniofacial malformation.