Gradient high-performance liquid chromatography using alkylphenone retention indices of insecticidal extracts of penicillium strains

Russell, Robert H.; Paterson, Marion; Kemmelmeier, Carlos

doi:10.1016/s0021-9673(01)93118-8

Cited by 20 publications

(2 citation statements)

References 16 publications

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“…Numerous chromatographic methods for analyses of phenols [11], fungi metabolites such as mycotoxines and aflatoxines [12–18], as well as active plant components [19–21], are presented in the literature. It is of obvious interest to develop and optimize experimental protocols, more particularly by tuning the earlier published methods, in view of routine analysis of the new skin‐lightening agents.…”

Section: Preparatory Analytical Assaysmentioning

confidence: 99%

Identification and quantitative analysis of kojic acid and arbutine in skin‐whitening cosmetics

Masse

Duvallet

Borremans

et al. 2001

Intern J of Cosmetic Sci

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After testing several chromatographic systems described in the literature, the optimal operating conditions were retained to develop a simple and rapid method grouping TLC and HPLC/UV for separation, identification and dosage of kojic acid (CAS RN 501-30-4) or arbutine (CAS RN 497-76-7) in skin-whitening cosmetic products. The screening is carried out by TLC on cellulose plate and by TLC on silicagel plate with UV indicator and polar mobile solvent. Regarding identification and quantitative determination by HPLC/UV, the best results were obtained by direct phase chromatography, using a polar stationary phase greffed with diol groups and a polar buffered mobile phase at PH 2,5. Intralaboratory prevalidation tests were carried out on the HPLC method: detection limit, linearity and intralaboratory repeatability of standard curves and repeatability of samples quantitative determination.

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Section: Preparatory Analytical Assaysmentioning

confidence: 99%

Identification and quantitative analysis of kojic acid and arbutine in skin‐whitening cosmetics

Masse

Duvallet

Borremans

et al. 2001

Intern J of Cosmetic Sci

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“…Thin layer chromatography (TLC) served as the most important tool for both the isolation of unknown molecules and the identification of known IDTs (El-Banna et al 1987; Sanchis et al 1988; Scuteri et al 1992). In addition to TLC, high performance liquid chromatography (HPLC) became increasingly important in this decade for the analysis of organic compounds, including natural product mycotoxins (Maes et al 1982; Frisvad 1987; Russell et al 1989). By 1987 a standardized HPLC method was developed that allowed the detection of all the important groups of mycotoxins and many other fungal secondary metabolites, covering 182 compounds (Frisvad and Thrane 1987).…”

Section: Detection and Structural Characterization Of Idts In Biologimentioning

confidence: 99%

Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications

Kozák

Szilágyi

Tóth

et al. 2019

Appl Microbiol Biotechnol

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Indole-diterpenes (IDTs) such as the aflatrems, janthitrems, lolitrems, paspalitrems, penitrems, shearinines, sulpinines, and terpendoles are biogenetically related but structurally varied tremorgenic and neurotoxic mycotoxins produced by fungi. All these metabolites derive from the biosynthetic intermediate paspaline, a frequently occurring IDT on its own right. In this comprehensive review, we highlight the similarities and differences of the IDT biosynthetic pathways that lead to the generation of the main paspaline-derived IDT subgroups. We survey the taxonomic distribution and the regulation of IDT production in various fungi and compare the organization of the known IDT biosynthetic gene clusters. A detailed assessment of the highly diverse biological activities of these mycotoxins leads us to emphasize the significant losses that paspaline-derived IDTs cause in agriculture, and compels us to warn about the various hazards they represent towards human and livestock health. Conversely, we also describe the potential utility of these versatile molecules as lead compounds for pharmaceutical drug discovery, and examine the prospects for their industrial scale manufacture in genetically manipulated IDT producers or domesticated host microorganisms in synthetic biological production systems.

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Determination of Viridicatin inPenicillium cyclopiumby Capillary Gas Chromatography

Bringmann

Mäder

Feineis

1997

Analytical Biochemistry

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Gradient high-performance liquid chromatography using alkylphenone retention indices of insecticidal extracts of penicillium strains

Cited by 20 publications

References 16 publications

Identification and quantitative analysis of kojic acid and arbutine in skin‐whitening cosmetics

Identification and quantitative analysis of kojic acid and arbutine in skin‐whitening cosmetics

Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications

Determination of Viridicatin inPenicillium cyclopiumby Capillary Gas Chromatography

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