Grading of posterior staphyloma with spectral-domain optical coherence tomography and correlation with macular disease

Rahimy, Ehsan; Beardsley, Robert S.; Gomez, Jessica; Hung, Crystal; Sarraf, David

doi:10.1016/j.jcjo.2013.07.006

Cited by 16 publications

(7 citation statements)

References 31 publications

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“…We investigated the association between posterior staphyloma with MMD and MTM using the latest standardized international classifications of MMD and MTM. Our analyses showed that staphyloma was associated significantly with these two myopic maculopathies, which is in line with earlier findings of specific myopic lesions that myopic choroidal atrophy, (Ohno‐Matsui 2014) myopic CNV, (Ohno‐Matsui 2014) macular hole, (Oie et al 2005) retinal schisis, (Benhamou et al 2002; Wu et al 2009; Rahimy et al 2013; Shinohara et al 2018) and foveal detachment (Baba et al 2003; Oie et al 2005; Wu et al 2009) were significantly more common in eyes with posterior staphyloma. These cross‐sectional data suggested that the presence of staphyloma was associated with more severe macular alterations and a higher prevalence of myopic maculopathy.…”

Section: Discussionsupporting

confidence: 91%

Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide‐field optical coherence tomography in Singapore adults with high myopia

Zheng

Wong

Sabanayagam

et al. 2020

Acta Ophthalmologica

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Purpose To investigate the prevalence and risk factors of posterior staphyloma using wide‐field optical coherence tomography (WF‐OCT) in adults with high myopia in Singapore. Design Population‐based cross‐sectional study. Methods Adults with spherical equivalent (SE) ≤ −5D in either eye at the first visit of Singapore Epidemiology of Eye Diseases study and Singapore Prospective Study Program study were recruited. Posterior staphyloma was diagnosed using WF‐OCT (PLEX®Elite9000, Carl Zeiss Meditec). Myopic macular degeneration (MMD), myopic traction maculopathy (MTM) and vision‐related quality of life (VRQoL) were assessed using fundus photographs, DRI‐Triton OCT (Topcon) and the Impact of Vision Impairment (IVI) questionnaire, respectively. Factors associated with posterior staphyloma were identified with multilevel, multivariable logistic regression. Impact of posterior staphyloma on MMD, MTM and visual function was analysed with multilevel, multivariable logistic regression and linear mixed model, respectively. Results Among the 225 eyes [mean SE = −6.5 ± 2.2 D, mean axial length (AL) = 26.2 ± 1.5 mm] of 117 participants (mean age = 60.3 ± 7.1 years), posterior staphyloma was detected in 47 (20.9%) eyes of 38 (32.5%) participants. Older age [odds ratio (OR), 1.18; 95% confidence interval (CI), 1.10–1.26], more myopic SE (0.63; 0.51–0.77) and increased AL (2.51; 1.69–3.73) were associated with higher prevalence of posterior staphyloma (all p < 0.001). Adults with posterior staphyloma had higher odds of MMD (2.67; 1.23–5.82; p = 0.013), MTM (3.79; 1.13–12.68; p = 0.031) and worse IVI Reading (β = −1.44; −2.31 to 0.58; p = 0.001) scores. Conclusions About one in three adults with high myopia had posterior staphyloma, which was associated with increased odds of having myopic maculopathy and a detrimental impact on VRQoL.

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Section: Discussionsupporting

confidence: 91%

Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide‐field optical coherence tomography in Singapore adults with high myopia

Zheng

Wong

Sabanayagam

et al. 2020

Acta Ophthalmologica

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“…It has been shown that myopic eyes have a steeper posterior retinal curvature than emmetropic eyes 34 . Thus, the DFD, based on two-dimensional images, may be underestimated in myopic eyes, especially in eyes with a posterior staphyloma 35 . Of note, most of the eyes included in present study were not high myopic eyes (the mean refractive error was −5.12 D).…”

Section: Discussionmentioning

confidence: 99%

Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes

Qiu

Wang

Zhang

et al. 2018

Sci Rep

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Assessment of macular thickness is important in the evaluation of various eye diseases. This study aimed to determine the influence of the optic disc-fovea distance (DFD) on macular thickness in myopic eyes. We determined the DFD and the macular thickness in 138 eyes from 138 healthy myopic subjects using the Cirrus HD-OCT. Correlation analysis and multiple linear regression were performed to determine the influence of DFD, axial length, disc area, and β-PPA on macular thickness. To further remove the confounding effect of ocular magnification on the DFD and OCT scan area, a subgroup analysis was performed in eyes with a limited axial length range (24–25 mm). DFD was significantly correlated with both regional (central, inner, and outer ETDRS subfields) and overall average macular thickness at a Bonferroni corrected P value of 0.004 (r ranging from −0.27 to −0.47), except for the temporal outer (r = −0.15, P = 0.089) and inferior outer (r = −0.22, P = 0.011) macular thickness. In the multivariable analysis, DFD was significantly associated with the average inner and outer macular thickness, the central subfield thickness, and the overall macular thickness (all P < 0.001), independent of ocular magnification and other covariates. Our findings indicate that eyes with a greater DFD have a lower macular thickness.

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“…Sometimes, the steepened curve of the posterior sclera caused by axial elongation may be confused with a staphyloma in some of the OCT studies. [51][52][53][54] Nevertheless, images obtained from T2-weighted MRI represented the fluid-filled chamber in the eye, which was not exactly the contour of the outer shell of the eye. OCT can be useful in studying the biometrics of the sclera, detecting more minute and subtle deformities within the staphyloma, and allows the analysis of the spatial relationship between morphology of the retinal and choroidal layers with the protruded sclera.…”

Section: Sclera and Staphylomamentioning

confidence: 99%

Advances of optical coherence tomography in myopia and pathologic myopia

Cheung

Luk

et al. 2016

Eye

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Grading of posterior staphyloma with spectral-domain optical coherence tomography and correlation with macular disease

Cited by 16 publications

References 31 publications

Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide‐field optical coherence tomography in Singapore adults with high myopia

Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide‐field optical coherence tomography in Singapore adults with high myopia

Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes

Advances of optical coherence tomography in myopia and pathologic myopia

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