Gradual strenuous running regimen predisposes to osteoarthritis due to cartilage cell death and altered levels of glycosaminoglycans

Franciozi, Carlos Eduardo da Silveira; Tarini, Victor Alexandre Ferreira; Reginato, Rejane Daniele; Gonçalves, Pricila Rodrigues; Medeiros, Valquíria P.; Ferretti, Mário; Dreyfuss, Juliana Luporini; Nader, Helena B.; Faloppa, Flávio

doi:10.1016/j.joca.2013.04.007

Cited by 41 publications

(48 citation statements)

References 49 publications

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“…Animal studies(36–38), as well as studies on knee injured patients(39, 40), and population-based cohort studies have suggested that high activity level may increase the risk of development and progression of knee OA(1), although conflicting results have been reported(41, 42). No universal definitions of high, moderate, and low activity level exist for walking, even though suggestions exist(43).…”

Section: Discussionmentioning

confidence: 99%

No Association between Daily Walking and Knee Structural Changes in People at Risk of or with Mild Knee Osteoarthritis. Prospective Data from the Multicenter Osteoarthritis Study

Øiestad

Quinn²,

White³

et al. 2015

J Rheumatol

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Objective We investigated the association between objectively measured daily walking and knee structural change, defined either as radiographic worsening or as cartilage loss, in people at risk of or with knee osteoarthritis (OA). Methods Participants from the Multicenter Osteoarthritis (MOST) study with Kellgren and Lawrence (KL) grades 0–2 and daily walking (measured with the StepWatch) at the 60-month visit, were included. Participants had fixed flexion weight bearing radiographs and knee magnetic resonance images (MRIs) at 60 and 84 months. Radiographic worsening was read in both knees using the OARSI grading, and MRIs were read for one knee using WORMS semiquantitative scoring. Odds ratios (OR) and 95% confidence intervals (CI) were calculated comparing those in the middle tertile against the lowest and highest tertiles of daily walking using logistic regression models and generalized estimating equations. Data on walking with moderate to vigorous intensity (minutes with >100 steps/min/day) was associated to structural change using multivariate and logistic regression models. Results The 1179 study participants (59% females) were 67.0 (±7.6) years, with a mean (±SD) body mass index of 29.8 (±5.3) kg/m2 who walked 6981 (±2630) steps/day. After adjusting for confounders, we found no significant associations between daily walking and radiographic worsening or cartilage loss. More time spent walking at a moderate to vigorous intensity was not associated with either radiographic worsening or cartilage loss. Conclusion Results from the MOST study indicated no association between daily walking and structural changes over two years in people at risk of or with mild knee OA.

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Section: Discussionmentioning

confidence: 99%

No Association between Daily Walking and Knee Structural Changes in People at Risk of or with Mild Knee Osteoarthritis. Prospective Data from the Multicenter Osteoarthritis Study

Øiestad

Quinn²,

White³

et al. 2015

J Rheumatol

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“…The plates were agitated for 5 minutes and the europium-free plate fluorescence was read on a fluorimeter. The results were expressed in ng/ml [13,14].…”

Section: Extraction and Quantification Of Sulfated Glycosaminoglycansmentioning

confidence: 99%

“…Previous studies [7][8][9][10][11][12][13][14][15][16] indicate that animals subjected to ESWT undergo neoangiogenesis and display increased expression of angiogenic markers, endothelial nitric oxide synthase, VEGF, and proliferating cell nuclear antigen. ESWT has been shown to induce membrane hyperpolarization and activation of Ras, a factor that operates in the initial phases of osteogenesis.…”

Section: Hyaluronic Acid Quantificationmentioning

confidence: 99%

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Effects of shock wave therapy on glycosaminoglycan expression during bone healing

Santos

Medeiros

Moura

et al. 2015

International Journal of Surgery

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“…Still, there is no consensus that anterior cruciate ligament reconstruction (ACLR) prevents osteoarthritis, but it is known that, once cartilage composition is damaged and load-bearing exceeds the low healing response of the tissue, there is increased catabolism and progression to osteoarthritis even in normal knees subjected to augmented mechanical stimuli [1][2][3]. ACLR is a common orthopedic procedure.…”

Section: Introductionmentioning

confidence: 99%

Updates in biological therapies for knee injuries: anterior cruciate ligament

Franciozi

Ingham

Gracitelli

et al. 2014

Curr Rev Musculoskelet Med

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There have been many advances in anterior cruciate ligament reconstruction (ACLR) techniques incorporating biological treatment. The aim of this review is to discuss the recent contributions that may enlighten our understanding of biological therapies for anterior cruciate ligament (ACL) injuries and improve management decisions involving these enhancement options. Three main biological procedures will be analyzed: bio-enhanced ACL repair, bio-enhanced ACLR scrutinized under the four basic principles of tissue engineering (scaffolds, cell sources, growth factors/cytokines including platelet-rich plasma, and mechanical stimuli), and remnant-preserving ACLR. There is controversial information regarding remnant-preserving ACLR, since different procedures are grouped under the same designation. A new definition for remnant-preserving ACLR surgery is proposed, dividing it into its three major procedures (selective bundle augmentation, augmentation, and nonfunctional remnant preservation); also, an ACL lesion pattern classification and a treatment algorithm, which will hopefully standardize these terms and procedures for future studies, are presented.

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Gradual strenuous running regimen predisposes to osteoarthritis due to cartilage cell death and altered levels of glycosaminoglycans

Abstract: The articular cartilage of rats subjected to a strenuous running regimen of controlled intensity exhibited molecular and histological characteristics that are present in osteoarthritis.

Cited by 41 publications

References 49 publications

No Association between Daily Walking and Knee Structural Changes in People at Risk of or with Mild Knee Osteoarthritis. Prospective Data from the Multicenter Osteoarthritis Study

No Association between Daily Walking and Knee Structural Changes in People at Risk of or with Mild Knee Osteoarthritis. Prospective Data from the Multicenter Osteoarthritis Study

Effects of shock wave therapy on glycosaminoglycan expression during bone healing

Updates in biological therapies for knee injuries: anterior cruciate ligament

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