No Association between Daily Walking and Knee Structural Changes in People at Risk of or with Mild Knee Osteoarthritis. Prospective Data from the Multicenter Osteoarthritis Study

Øiestad, Britt Elin; Quinn, Emily; White, Daniel K.; Roemer, Frank W.; Guermazi, Ali; Nevitt, Michael C.; Segal, Neil A.; Lewis, Cora E.; Felson, David T.

doi:10.3899/jrheum.150071

Cited by 23 publications

(28 citation statements)

References 51 publications

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“…This is somewhat consistent with a previous study which reported that patients with all grades of OA severity on MRI could benefit from professional supervised exercise therapy, although the effects might be reduced in patients with advanced patellofemoral osteoarthritis (PF OA) 46 . The Multicentre Osteoarthritis (MOST) study reported no association between daily walking and structural changes over 2 years in people at risk of mild knee OA 47 , however, this study was limited by the assessment of a narrow range of step frequency.…”

Section: Discussionmentioning

confidence: 88%

Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes

Zhu

Aitken

Cicuttini

et al. 2019

Osteoarthritis and Cartilage

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s u m m a r yObjective: To investigate the longitudinal association between objectively measured ambulatory activity (AA) and knee MRI-detected osteophytes (OPs), and to test whether this relationship was modified by common risk factors for OA including sex, obesity, disease severity and knee injury history. Methods: 408 community-dwelling adults aged 51e81 years were assessed at baseline and 2.7 years. T1weighted fat-suppressed MRI was used to evaluate knee OPs at both time points. AA was assessed at baseline by pedometers and categorized as: less active ( 7499 steps per day), moderately active (7500 e9999 steps per day) and highly active (!10,000 steps per day). Results: Statistically significant interactions were detected between knee OA risk factors and AA on increases in MRI-detected OPs (all P < 0.05). In stratified analyses, being moderately active, compared to being less active, was protective against an increase in MRI-detected OPs (score change of !1) in females (relative risk (RR) ¼ 0.42, 95%CI, 0.25e0.70, P < 0.01), those who were obese (RR ¼ 0.50, 95%CI, 0.30 e0.83, P < 0.01), those with radiographic OA (ROA) (RR ¼ 0.68, 95%CI, 0.47e0.97, P ¼ 0.02) and those with a history of knee injury (RR ¼ 0.27, 95%CI, 0.08e0.88, P ¼ 0.02) in almost every knee compartment, after adjustment for confounders. No statistically significant associations were found in males, non-obese, non-ROA or non-injury groups. Conclusions: Being moderately active is protective against an increase in MRI-detected OPs in females, those with ROA, those who are obese and those with a history of knee injury. These findings suggest that being moderately active is beneficial for individuals who are at higher risk of knee OA.

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Section: Discussionmentioning

confidence: 88%

Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes

Zhu

Aitken

Cicuttini

et al. 2019

Osteoarthritis and Cartilage

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“…Our findings are in keeping with the few previous studies that utilized objective measures of physical activity. In the MOST Study, in persons at higher risk or with mild OA, there was no association between daily walking, measured objectively using a StepWatch or with time spent walking at a moderate to vigorous intensity at the 60‐month visit and radiographic progression by the 84‐month visit . In OAI participants at higher risk of knee OA but free of the outcome of interest, ≥150 minutes per week of moderate‐vigorous physical activity was not associated with incident radiographic knee OA, symptomatic knee OA, or joint space narrowing versus <10 minutes of moderate‐vigorous activity per week .…”

Section: Discussionmentioning

confidence: 91%

“…In OAI participants at higher risk of knee OA but free of the outcome of interest, ≥150 minutes per week of moderate‐vigorous physical activity was not associated with incident radiographic knee OA, symptomatic knee OA, or joint space narrowing versus <10 minutes of moderate‐vigorous activity per week . Longitudinal studies using MRI‐based outcomes have also mostly relied on self‐reported physical activity , with some exceptions ; these studies have had mixed results.…”

Section: Discussionmentioning

confidence: 99%

“…With few exceptions , longitudinal studies that evaluated the association between physical activity and worsening of radiographic knee OA have relied on self‐report to quantify physical activity however; self‐report is vulnerable to reporting bias and imprecise recall. Accelerometry provides an objective method to quantify physical activity intensity and duration in daily‐life settings.…”

Section: Introductionmentioning

confidence: 99%

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Physical Activity and Worsening of Radiographic Findings in Persons With or at Higher Risk of Knee Osteoarthritis

Jayabalan

Kocherginsky

Chang

et al. 2019

Arthritis Care & Research

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Objective. The benefits of physical activity among persons with or at higher risk for knee osteoarthritis are well established. However, activity levels in this population are low, in part due to concern that activity will damage the knee joint. We hypothesized that sedentary and moderate-vigorous physical activity are each associated with greater risk of radiographic worsening of knee OA.Methods. In Osteoarthritis Initiative participants with or at higher risk for knee OA enrolled in an accelerometer substudy at 48 months (study baseline), physical activity was measured by a uniaxial accelerometer (ActiGraph GT1M). Radiographic progression was defined as any 48 month to 96 month worsening of Kellgren/Lawrence (K/L) grade scores. All analyses were knee-level; we used multivariable logistic regression with generalized estimating equations, adjusting for key covariates.Results. Of the 1,206 participants, 631 (52%) were female, the mean ± SD age was 64 ± 9 years, and mean ± SD body mass index (BMI) was 28 ± 5. The mean ± SD average daily sedentary activity was 602 ± 86 minutes, average daily light activity was 284 ± 75 minutes, and average daily moderate-vigorous activity was 20 ± 20 minutes. In 1,978 knees, 267 (14%) had worsening of K/L grade scores. In the multivariable model, age, sex, BMI, and pain, were associated with K/L grade worsening, but neither sedentary activity (adjusted odds ratio [OR] 0.99 [95% confidence interval (95% CI) 0.97-1.01]) nor moderate-vigorous activity (adjusted OR 1.00 [95% CI 0.91-1.09]) were associated with K/L grade worsening.Conclusion. In persons with or at higher risk for knee OA, age, sex, BMI, and pain, but not objectively mea sured average daily minutes of sedentary or moderate-vigorous activity, were associated with subsequent worsening of K/L grade. Whether findings differ in persons with more severe knee OA and/or engaged more frequently in moderatevigorous activity should be examined in future studies.

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“…However, it has been reported that abnormal findings on simple X-ray and MRI examinations may not necessarily match subjective pain and clinical symptoms13 ) . In this study, all measurements were taken at a regional community center rather than at a medical venue; therefore the following method for simple knee-joint malalignment assessment was used.…”

Section: Methodsmentioning

confidence: 99%

Associations of knee muscle force, bone malalignment, and knee-joint laxity with osteoarthritis in elderly people

Nakagawa

Maeda²

2017

J Phys Ther Sci

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[Purpose] From the viewpoint of prevention of knee osteoarthritis, the aim of this study was to verify how muscle strength and joint laxity are related to knee osteoarthritis. [Subjects and Methods] The study subjects consisted of 90 community-dwelling elderly people aged more than 60 years (22 males, 68 females). Femorotibial angle alignment, knee joint laxity, knee extensors and flexor muscle strengths were measured in all subjects. In addition, the subjects were divided into four groups based on the presence of laxity and knee joint deformation, and the muscle strength values were compared. [Results] There was no significant difference in knee extensor muscle strength among the four groups. However, there was significant weakness of the knee flexor muscle in the group with deformation and laxity was compared with the group without deformation and laxity. [Conclusion] Decreased knee flexor muscle strengths may be involved in knee joint deformation. The importance of muscle strength balance was also considered.

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No Association between Daily Walking and Knee Structural Changes in People at Risk of or with Mild Knee Osteoarthritis. Prospective Data from the Multicenter Osteoarthritis Study

Cited by 23 publications

References 51 publications

Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes

Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes

Physical Activity and Worsening of Radiographic Findings in Persons With or at Higher Risk of Knee Osteoarthritis

Associations of knee muscle force, bone malalignment, and knee-joint laxity with osteoarthritis in elderly people

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