Graft Healing After Anterior Cruciate Ligament Reconstruction in Rabbits

Panni, Alfredo Schiavone; Milano, Giuseppe; Lucania, L.; Fabbriciani, C.

doi:10.1097/00003086-199710000-00031

Cited by 66 publications

(50 citation statements)

References 29 publications

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“…There is substantial evidence that normal bone-tendon attachment-site morphology is not recapitulated during healing [1][2][3][4][5][6][7] . The native insertion site contains four distinct types of tissue: tendon, unmineralized fibrocartilage, mineralized fibrocartilage, and bone.…”

Section: Discussionmentioning

confidence: 99%

“…No significant differences were detected among the immobilized (n = 8), immediate-loading (n = 7), and delayedloading (n = 11) groups with regard to either load to failure (top) or stiffness (bottom). 7,2014 and biological parameters of tendon-to-bone healing compared with those seen after immediate loading or prolonged immobilization of the knee 14 . The results of the current study are partially consistent with these findings, as we found that the mean bone volume of the entire tibial tunnel was higher in both the immobilized group and the delayed-loading group when compared with the immediate-loading group (p = 0.06).…”

Section: Discussionmentioning

confidence: 99%

“…Rather, an interposed layer of fibrovascular scar tissue is formed that is biomechanically inferior to the native enthesis and that may predispose tendonto-bone repairs to an increased rate of failure [1][2][3][4][5][6][7] . While anterior cruciate ligament (ACL) reconstruction generally has favorable Disclosure: One or more of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of an aspect of this work.…”

mentioning

confidence: 99%

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Effect of Immediate and Delayed High-Strain Loading on Tendon-to-Bone Healing After Anterior Cruciate Ligament Reconstruction

Packer

Bedi

Fox

et al. 2014

Journal of Bone and Joint Surgery

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of Immediate and Delayed High-Strain Loading on Tendon-to-Bone Healing After Anterior Cruciate Ligament Reconstruction

Packer

Bedi

Fox

et al. 2014

Journal of Bone and Joint Surgery

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“…These fibres could be considered as Sharpey's fibres, which were first described by Sharpey and Ellis as the "perforating fibres" extending between periosteum and underlying bone at the site of insertion of tendon [2,6]. Several studies showed the restoration of Sharpey collagen fibre continuity between bone and tendon in animal models [3,8,10,11]. Another finding at the junction of the insertion of the tendon to bone was the formation of a layered structure of fibrocartilage by 12 weeks.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of the healing of tendon autograft and tendon-bone autograft using patellar tendon in rabbits

Park

Lee

Seong

2001

International Orthopaedics (SICOT)

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In order to compare the healing of tendon to bone and the healing of bone to bone in a rabbit model, the lateral 4 mm of patellar tendons were detached from their insertion into the tibia either subperiosteally (group I) or with a bone block (group II) and implanted into drill holes in the proximal articular surface of the tibia. The histological and biomechanical features of the graft incorporation were observed at 2, 4, 8 and 12 weeks. Histological patterns similar to normal tendon-bone attachment were seen at the tendon-bone interface in group I by 12 weeks, while direct bony union was seen in group II by 8 weeks. The maximum tensile load and stiffness were significantly greater in group II at 4 and 8 weeks while the difference between the two groups was not significant at 2 and 12 weeks. These findings show that more rapid incorporation of the graft occurs in group II although no significant difference in biomechanical parameters was noted once healing was complete.Résumé Pour comparer la cicatrisation de tendon à os et la cicatrisation d'os à os chez le lapin, on a séparé une bande latérale de 4 mm du tendon rotulien soit en souspériosté (groupe I), soit avec une pastille osseuse (groupe II). Et puis, on l'a implantée dans le trou foré dans la surface articulaire proximale du tibia. Enfin, on a observé l'aspect histologique et biomécanique de l'incorporation de la greffe à la 2ème, 4ème, 8ème et 12ème semaine. On trouve un aspect histologique habituel de la jonction os-tendon normal dans le groupe I à 12 semaines tandis que 1'on peut voir 1'union osseuse directe dans le groupe II à 8 semaines. La charge admissible maximale et la résistance sont plus élevées dans le groupe II à la 4ème et 8ème semaine mais non aux semaines 2 et 12. Mais la différence entre deux groupes n'a pas été significative à 4ième et à 12ième semaine. Cela démon-tre que 1'incorporation de la greffe dans le groupe II se produit plus rapidement. Mais il n'y a pas de différence significative dans les paramètres biomécaniques après cicatrisation. IntroductionUnderstanding the mechanism of graft incorporation into bone is essential for successful reconstruction of knee ligaments using autograft structures. Among the techniques available for the reconstruction of knee ligaments, bone-patellar tendon-bone has been favoured by many surgeons as graft incorporation is achieved through bone-to-bone healing [1,4,5]. However, a bonetendon-bone structure is only provided by the bonepatellar tendon-bone technique. The increasing popularity of using tendons such as semitendinosus and gracilis has made it necessary to understand the incorporation process of the tendon graft at the insertion site, as postoperative rehabilitation depends on the histological restoration of a normal tendon-bone interface.The purpose of this study was to compare biological properties of tendon-to-bone healing and bone-to-bone healing using autograft structures in an animal model. Materials and methodsSkeletally mature New Zealand white rabbits weighing 3.4-3.8 kg we...

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“…There are no analogous sites in humans where a native tendon passes through a bone tunnel, however, and the biology of this unique environment remains incompletely understood. Wide variations in the morphological characteristics of the tendon-bone attachment site have been reported [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Some studies have demonstrated formation of a native, direct type of insertion and an intermediate fibrocartilage zone at the interface.…”

Section: Discussionmentioning

confidence: 99%

Differences in Tendon Graft Healing between the Intra-articular and Extra-articular Ends of a Bone Tunnel

Bedi

Kawamura

Liang

et al. 2009

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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The basic biology of healing between a tendon graft and bone tunnel remains incompletely understood. Distinct variability in the morphological characteristics of the healing tendon-bone attachment site has been reported. We hypothesized that spatial and temporal differences in tendon-to-bone healing exist at different regions of a surgically created bone tunnel. Twenty-four male, Sprague-Dawley rats underwent anterior cruciate ligament (ACL) reconstruction in the left knee using a flexor digitorum longus tendon graft secured using suspensory periosteal fixation.

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Graft Healing After Anterior Cruciate Ligament Reconstruction in Rabbits

Cited by 66 publications

References 29 publications

Effect of Immediate and Delayed High-Strain Loading on Tendon-to-Bone Healing After Anterior Cruciate Ligament Reconstruction

Effect of Immediate and Delayed High-Strain Loading on Tendon-to-Bone Healing After Anterior Cruciate Ligament Reconstruction

A comparative study of the healing of tendon autograft and tendon-bone autograft using patellar tendon in rabbits

Differences in Tendon Graft Healing between the Intra-articular and Extra-articular Ends of a Bone Tunnel

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