Graft-versus-host disease: A rare complication of device implantation

Xu, Jack; Watts, Thomas E.; Tobler, Gareth; Paydak, Hakan

doi:10.1016/j.hrcr.2016.07.005

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Further, allergy to pacemaker compounds and infection can be hard to distinguish, as highlighted in Robledo-Nolasco's paper regarding the 17F treated with antibiotics for 18 months for a presumed pacemaker infection -only to later find this was a case of nickel rejection [59]. Xu and colleagues explore this topic further and discuss 'Graft-versus-host disease' of implanted devices [60].…”

Section: Medical Specialties -Healthcare Technologiesmentioning

confidence: 99%

21st century medicine and emerging biotechnological syndromes: a cross-disciplinary systematic review of novel patient presentations in the age of technology

Straw,

Rees,

Nachev

2023

BMC Digit Health

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Background Biotechnological syndromes refer to the illnesses that arise at the intersection of human physiology and digital technology. Now that we experience health and illness through so much technology (e.g. wearables, telemedicine, implanted devices), the medium is redefining our expression of symptoms, the observable signs of pathology and the range of diseases that may occur. Here, we systematically review all case reports describing illnesses related to digital technology in the past ten years, in order to identify novel biotechnological syndromes, map out new causal pathways of disease, and identify gaps in care that have disadvantaged a community of patients suffering from these digital complaints. Methods PubMed, MEDLINE, Scopus, Cochrane Library and Web of Science were searched for case reports and case series that described patient cases involving biotechnological syndromes from 01/01/2012 to 01/02/2022. For inclusion the technology had to play a causative role in the disease process and had to be digital (as opposed to simple electronic). Results Our search returned 7742 articles, 1373 duplicates were removed, 671 met the criteria for full review and 372 were included in the results. Results were categorised by specialty, demonstrating that syndromes were most common in Cardiology (n = 162), Microbiology and Infectious Diseases (n = 36), and Emergency and Trauma (n = 26). Discussion The 372 unique patient cases demonstrated a range of severity from mild (e.g., injuries related to Pokemon Go) to moderate (e.g. pacemaker-generated rib fractures) and severe (e.g. ventilator software bugs causing cardiac arrest). Syndromes resulted from both consumer technology (e.g. gaming addictions) and medical technologies (e.g. errors in spinal stimulators). Cases occurred at both the individual level (e.g. faulty insulin pumps) and at the population level (e.g. harm from healthcare cyberattacks). Limitations This was a retrospective systematic review of heterogeneous reports, written in English, which may only reflect a small proportion of true prevalence rates in the population.

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Section: Medical Specialties -Healthcare Technologiesmentioning

confidence: 99%

21st century medicine and emerging biotechnological syndromes: a cross-disciplinary systematic review of novel patient presentations in the age of technology

Straw,

Rees,

Nachev

2023

BMC Digit Health

View full text Add to dashboard Cite

show abstract

“…Further, allergy to pacemaker compounds and infection can be hard to distinguish, as highlighted in Gulak's paper regarding the 17F treated with antibiotics for 18 months for a presumed pacemaker infection -only to later nd this was a case of nickel rejection (58). Xu and colleagues explore this topic further and discuss 'Graft-versus-host disease' of implanted devices (59).…”

Section: Medical Specialtiesmentioning

confidence: 99%

21st century medicine and emerging biotechnological syndromes: a cross- disciplinary systematic review of novel patient presentations in the age of technology

Straw

Rees

Nachev

2023

Preprint

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Background Biotechnological syndromes refer to the illnesses that arise at the intersection of human physiology and digital technology. Now that we experience health and illness through so much technology (e.g. wearables, telemedicine, implanted devices), the medium is redefining our expression of symptoms, the observable signs of pathology and the range of diseases that may occur. Here, we systematically review all case reports describing illnesses related to digital technology in the past ten years, in order to identify novel biotechnological syndromes, map out new causal pathways of disease, and identify gaps in care that have disadvantaged a community of patients suffering from these digital complaints. Methods PubMed, MEDLINE, Scopus, Cochrane Library and Web of Science were searched for case reports and case series that described patient cases involving biotechnological syndromes from 01/01/2012 to 01/02/2022. For inclusion the technology had to play a causative role in the disease process and had to be digital (as opposed to simple electronic). Results Our search returned 7742 articles, 1373 duplicates were removed, 671 met the criteria for full review and 372 were included in the results. Results were categorised by specialty, demonstrating that syndromes were most common in Cardiology (n = 162), Microbiology and Infectious Diseases (n = 36), and Emergency and Trauma (n = 26). Discussion The 372 unique patient cases demonstrated a range of severity from mild (e.g., injuries related to Pokemon Go) to moderate (e.g. pacemaker-generated rib fractures) and severe (e.g. ventilator software bugs causing cardiac arrest). Syndromes resulted from both consumer technology (e.g. gaming addictions) and medical technologies (e.g. errors in spinal stimulators). Cases occurred at both the individual level (e.g. faulty insulin pumps) and at the population level (e.g. harm from healthcare cyberattacks). Limitations This was a retrospective systematic review of heterogeneous reports which may only reflect a small proportion of true prevalence rates in the population.

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“…Of note, direct anatomical projections from the BLA exist to the ventral pole of the hippocampal formation [32]. Indeed, many lesion studies as well as pharmacological and optogenetic interventions demonstrate that especially the ventral hippocampus contributes to the formation and expression of cued and contextual fear memory, while the dorsal portion mediates predominantly cognitive processes such as spatial learning and pattern separation processes [33–36]. However, cognitive processes in the dorsal hippocampus might also be required for determining the specific context in which fear conditioning took place, thereby avoiding generalization of fear memory to other nonreinforced stimuli or environments [37–40].…”

Section: Procedures Processes and Circuits Of Fear Conditioningmentioning

confidence: 99%

Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions

Albrecht

Stork

2017

Neural Plasticity

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The formation of fear memories is a powerful and highly evolutionary conserved mechanism that serves the behavioral adaptation to environmental threats. Accordingly, classical fear conditioning paradigms have been employed to investigate fundamental molecular processes of memory formation. Evidence suggests that a circadian regulation mechanism allows for a timestamping of such fear memories and controlling memory salience during both their acquisition and their modification after retrieval. These mechanisms include an expression of molecular clocks in neurons of the amygdala, hippocampus, and medial prefrontal cortex and their tight interaction with the intracellular signaling pathways that mediate neural plasticity and information storage. The cellular activities are coordinated across different brain regions and neural circuits through the release of glucocorticoids and neuromodulators such as acetylcholine, which integrate circadian and memory-related activation. Disturbance of this interplay by circadian phase shifts or traumatic experience appears to be an important factor in the development of stress-related psychopathology, considering these circadian components are of critical importance for optimizing therapeutic approaches to these disorders.

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Graft-versus-host disease: A rare complication of device implantation

Cited by 3 publications

References 9 publications

21st century medicine and emerging biotechnological syndromes: a cross-disciplinary systematic review of novel patient presentations in the age of technology

21st century medicine and emerging biotechnological syndromes: a cross-disciplinary systematic review of novel patient presentations in the age of technology

21st century medicine and emerging biotechnological syndromes: a cross- disciplinary systematic review of novel patient presentations in the age of technology

Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions

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