Graft-versus-host reactions by NZB lymphoid cells exposed to major or minor histocompatibility antigens in irradiated adult mice

Cytolytic T lymphocyte (CTL) functions were compared in mice between the ages of 2 and 30 months. The stimulator cells were H-2 allogeneic spleen or tumor cells, parental-strain spleen cells, or syngeneic tumor cells. Effector cells capable of lysing syngeneic tumor cells were shown to be T cells and not NK cells. The cell-mediated lympholysis (CML) responses by spleen cells of aged mice were near normal against H-2 allogeneic spleen or tumor cells but were defective against syngeneic tumor cells or parental-strain spleen cells. The defective syngeneic tumor CML response was observed at various responder:stimulator ratios and at various days of incubation. The defect was in the nonadherent, and not in the adherent, fraction of spleen cells. Suppressor cells were detected in spleens of 30 month, but not of 18 month old mice. Aged mice were more susceptible than young mice to small inocula of syngeneic C57BL EL-4 lymphoma cells. The immunogenicity of irradiated spleen cells of old mice had not changed for the F1 antiparent CML response. Splenic CML responses of young mice treated with 89Sr demonstrated a similar pattern, i.e., good responses to H-2 allogeneic stimulator cells but poor responses to syngeneic tumor cells or to parental-strain spleen cells. This loss of certain CTL functions influenced by marrow dependent cells can partially explain the increased susceptibility of old animals to tumors.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Graft-versus-host reactions by NZB lymphoid cells exposed to major or minor histocompatibility antigens in irradiated adult mice

Cited by 3 publications

References 39 publications

A comparative study of [3H]thymidine and [125I]iodo-2′-deoxyuridine uptake as indicators of in vivo cell proliferation induced by graft-versus-host reaction in the mouse

A comparative study of [3H]thymidine and [125I]iodo-2′-deoxyuridine uptake as indicators of in vivo cell proliferation induced by graft-versus-host reaction in the mouse

Primary in vivo T Cell Reactivity of NZB Grafts in H-2 Identical Allogenic Hosts

Aging of Natural and Acquired Immunity of Mice. II. DecreasedTCell Responses to Syngeneic Tumor Cells and Parental-Strain Spleen Cells

Contact Info

Product

Resources

About