Grafting of Gd-DTPA onto MOF-808 to enhance MRI performance for guiding photothermal therapy

Jia, Mingjie; Yang, Xinyu; Chen, Yanan; He, Meie; Zhou, Weixiu; Lin, Jiaomin; An, Lin; Yang, Shiping

doi:10.1039/d1tb01596f

Cited by 22 publications

(14 citation statements)

References 48 publications

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“…It is also a non-invasive diagnostic imaging technique. 38,41 Mn-based MOF is a potential T 1 -weighted magnetic resonance imaging (MRI) contrast agent. Therefore, to evaluate the possibility of Nano Mn(III)-TP as an MRI reagent, the T 1 -weighted MRI properties of Nano Mn(III)-TP and GSH treated Nano Mn(III)-TP were determined in vitro via a 1.5 T MRI scanner (Fig.…”

Section: Loading Of Drugmentioning

confidence: 99%

“…Higher relaxation rates at the same concentration provide better contrast images, and T 1 -weighted images are often used to assess the anatomical structures at specific sites, while T 2 -weighted images are utilized to monitor tissue lesions. [38][39][40][41] Mn 2+ contains five unpaired electrons with a slow relaxation rate, and therefore Mn 2+ based MOFs are potential contrast agents for T 1 -weighted magnetic resonance imaging (MRI). Lu designed and synthesized Mn-IR825 from Mn 2+ and IR825, and functionalized Mn-IR825 containing a layer of polydopamine (PDA) by polyethylene glycol (PEG), finally obtaining the T 1 -weighted MRI agent Mn-IR825@PDA-PEG.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of nanoscale cationic metal–organic framework Nano Mn(iii)-TP for theranostics based on valence changes

et al. 2022

J. Mater. Chem. B

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Section: Loading Of Drugmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation of nanoscale cationic metal–organic framework Nano Mn(iii)-TP for theranostics based on valence changes

et al. 2022

J. Mater. Chem. B

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“…Encapsulation of superparamagnetic nanoparticles in MOFs may provide effective contrast agents as an alternative method [ 92 ]. As a platform for MRI-guided photothermal treatment, Gd-DTPA-grafted MOF-808 nanoparticles with a polyaniline (PANI) surface modification are utilized [ 93 ]. The resultant MOF has a high longitudinal relaxivity (30.1 mM −1 s −1 ) that is 5.4 times higher than other contrast agents [ 93 ].…”

Section: Biological Applications Of Mofmentioning

confidence: 99%

“…As a platform for MRI-guided photothermal treatment, Gd-DTPA-grafted MOF-808 nanoparticles with a polyaniline (PANI) surface modification are utilized [ 93 ]. The resultant MOF has a high longitudinal relaxivity (30.1 mM −1 s −1 ) that is 5.4 times higher than other contrast agents [ 93 ]. To overcome Gd’s toxicity, several researchers are now concentrating on alternate metal-based MOFs.…”

Section: Biological Applications Of Mofmentioning

confidence: 99%

Progressive Trends on the Biomedical Applications of Metal Organic Frameworks

et al. 2022

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Novel materials have been developed because of technological advancements combined with material research. Metal-organic frameworks (MOF) technology has been investigated for biomedical applications in this line. Nonetheless, as our team has learned from current literature, selecting metal ions/organic linkers, synthesis techniques, water stability/solubility, toxicity, and the possibility of biomolecules/drugs (enzyme, protein, DNA/RNA, and antibodies, among others) tagging/conjugation are the major challenges/factors. These issues/factors have an impact on MOFs’ performance in biomedical applications, and they also raise a lot of doubts about its real-time biological utility in the near future. We targeted a comprehensive review on the MOFs for biomedical applications to keep these considerations in mind. The evolution of MOF technology is based on their interesting features such as biological or pharmacological activity, biocompatibility, limited toxicity, and particular host–guest interactions, as well as environmental friendliness. In this paper, we have summarized the state-of-the-art progress pertaining to MOFs’ biomedical applications such as biosensing, biomedical, and drug delivery applications in this field that is still very new.

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“…Currently, chemotherapy, radiotherapy, and surgery are conventional cancer treatments. The side effects of these therapies are not only toxic, but cause panic to patients ( Liang et al, 2016 ; Song et al, 2016 ; Jia et al, 2021 ). Therefore, minimally invasive medical technology causes much research interest, which could potentially avoid the above disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Recent Development of MOF-Based Photothermal Agent for Tumor Ablation

Yin

Han

2022

Front. Chem.

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Metal-organic frameworks (MOFs) are 3D-architecture compounds of metal ions and organic molecules with sufficient and permanent porosity, showing great potential as a versatile platform to load various functional moieties to endow the hybrid materials with specific applications. Currently, a variety of photothermal nanometals have been embedded into organic ligands for integrating the unique photothermal effects with the merits of MOFs to improve their performances for cancer therapy. In this review, we have summarized a series of novel MOF-based photothermal materials for this unique therapeutic modality against tumors from three main aspects according to their chemical compositions and structures, i) metal-doped MOF, ii) organic-doped MOF, and iii) polymer-coated MOF. In addition, we have summarized the latest developments and characteristics of MOF-based photothermal agents, such as good biocompatibility, low toxicity, and responsive photothermal conversion without destroying the structure of hybrid photothermal agent. At last, we addressed the future perspectives of MOF-based photothermal agent in the field of phototherapy.

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Grafting of Gd-DTPA onto MOF-808 to enhance MRI performance for guiding photothermal therapy

Abstract: Gd(III) chelates are important T1-weighted contrast agents used in clinical magnetic resonance imaging (MRI), but their low longitudinal relaxivity (r1) results in limited imaging efficiency. In this work, we utilize...

Cited by 22 publications

References 48 publications

Preparation of nanoscale cationic metal–organic framework Nano Mn(iii)-TP for theranostics based on valence changes

Preparation of nanoscale cationic metal–organic framework Nano Mn(iii)-TP for theranostics based on valence changes

Progressive Trends on the Biomedical Applications of Metal Organic Frameworks

Recent Development of MOF-Based Photothermal Agent for Tumor Ablation

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