Grafting of vinyl monomers on the surface of a poly(ethylene terephthalate) film using Ar plasma-post polymerization technique to increase biocompatibility

Abstract

SUMMARY Surface modified poly(ethy1ene terephthalate) (PET) films with 2-(methacryloyloxy)ethylphosphorylcholine (MPC) and 2-(glucosy1oxy)ethyl methacrylate (GEMA) moieties, PMPC-g-PET and PGEMAg-PET, were prepared by graft copolymerization using an Ar plasma-post polymerization technique. The degrees of polymerization of the grafts PMPC and PGEMA were p,, = 30 and p,, = 40, respectively. The contact angle of the modified PET film decreased from 6' = 68 O (the original PET film) to 6' = 26 O for PMPCg-PET and to 6' = 43 O for PGEMA-g-PET. The modified PET films adsorb less serum proteins than the original PET film. Egg yolk lecithin did not adsorb on PGEMA-g-PET but adsorbed on PMPC-g-PET. PMPC-g-PET showed activity for the inhibition of fibrin formation and no adhesion of mouse fibroblasts (L-929).

Chemical surface modification of poly(ethylene terephthalate) fibers by aminolysis and grafting of carbohydrates

“…The functionalization of a polymer surface proceeds generally in two steps with the first one used as a pretreatment to create a high enough quantity of reactive functions to incorporate covalently the desired molecules in the second step. The pretreatment step can be achieved by chemical16 or physical processes 17…”

Characterization and application of polypropylene films modified with stimuli‐sensitive copolymers with an Ar‐plasma postpolymerization technique

“…A radio‐frequency (13.56 MHz) plasma reactor consisting of a glass chamber (7 cm in height and 21 cm in diameter) and copper plate electrodes was used as described in previous articles 25, 26. The conditions determined as optimum for the Ar‐plasma treatment were as follows: initial pressure = 1.3 Pa, radio frequency (RF) power = 10 W, Ar flow rate = 10 sccm, and irradiation time = 120 s.…”

Grafting of Biocompatible Polymers on DLC Thin Films by Plasma Irradiation-Post Polymerization Technique for Application of Biomedical Devices and Cell Microarrays

“…A strip of DLC coated an aluminum film (10 mm × 10 mm, thickness=50 μm) was washed with methanol, dried in a vacuum at room temperature. After the film was irradiated with Ar plasma [13], a known amount of LysMA or MPC was post-graft polymerized in the presence of ammonium peroxodisulfate in phosphate buffer saline (PBS: pH=7.4) or ethanol solution at 70℃ for 20 h to give the PLysMA or PMPC grafted DLC(/COOH) [PLysMA/PMPC-g-DLC(/COOH)].…”

“…Surface characterization of g-DLC(/COOH) was analyzed from contact angle to water [13], scanning probe microscope (SPM: Shimzu SPM-9500J3) by phase imaging mode, and X-ray photoelectron spectroscopy (XPS: Jeol JPS9010). XPS measurements were carried out with nonmonochromatized AlK α rays (1486.3 eV) as a X-ray source, at an acceleration voltage of 10 kV, an emission current of 10 mA.…”

“…In the case of plasma irradiation-post polymerization, the graft polymerization is initiated with peroxides generated by oxidation when the organic surface is brought into contact with air after exposure to Ar plasma [13]. The generated peroxides on the surface of DLC(/COOH) were detected with the DPPH as a radical scavenger according to the previous report [13]. Figure 2 shows the concentration of free radicals on the DLC film calculated from the DPPH consumption as a function of Ar plasma irradiation time.…”