Grand Rounds--Hammersmith Hospital: Hazards of running a marathon

Gr, Thompson

doi:10.1136/bmj.314.7086.1023

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Others have also observed elevated AST levels in the blood of runners after a 21-km race ( 27 ) and after a marathon ( 21 ). Plasma elevation of AST and other intracellular proteins such as creatine kinase, lactate dehydrogenase and myoglobin, may indicate exertional rhabdomyolysis and leakage of proteins from skeletal muscle cells ( 4 , 28 ), whereas ALT, a more specific marker for hepatic injury, showed little change in response to exercise. Since ALT, but not AST, was increased in the present study, plasma levels of ALT might be attributed mainly to leakage from muscle and not liver cells.…”

Section: Discussionmentioning

confidence: 99%

Leukocytosis, muscle damage and increased lymphocyte proliferative response after an adventure sprint race

Tossige-Gomes

Ottone

Oliveira

et al. 2014

Braz J Med Biol Res

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The effect of an adventure sprint race (ASR) on T-cell proliferation, leukocyte count and muscle damage was evaluated. Seven young male runners completed an ASR in the region of Serra do Espinhaço, Brazil. The race induced a strong leukocytosis (6.22±2.04×103 cells/mm3 before vs 14.81±3.53×103 cells/mm3 after the race), marked by a significant increase of neutrophils and monocytes (P<0.05), but not total lymphocytes, CD3+CD4+ or CD3+CD8+ cells. However, the T-cell proliferative response to mitogenic stimulation was increased (P=0.025) after the race, which contradicted our hypothesis that ASR, as a high-demand competition, would inhibit T-cell proliferation. A positive correlation (P=0.03, r=0.79) was observed between the proliferative response of lymphocytes after the race and the time to complete the race, suggesting that the proliferative response was dependent on exercise intensity. Muscle damage was evident after the race by increased serum levels of aspartate amino transferase (24.99±8.30 vs 50.61±15.76 U/L, P=0.003). The results suggest that humoral factors and substances released by damaged muscle may be responsible for lymphocyte activation, which may be involved in muscle recovery and repair.

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Section: Discussionmentioning

confidence: 99%

Leukocytosis, muscle damage and increased lymphocyte proliferative response after an adventure sprint race

Tossige-Gomes

Ottone

Oliveira

et al. 2014

Braz J Med Biol Res

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“…De entre estos últimos destacan las observaciones realizadas por separado por los Drs. Thompson [40] y Hood [41] sobre el comportamiento de la CK durante y después de realizar una maratón al aportar datos precisos sobre la evolución cronológica de este enzima tras el daño muscular. Hood describe cómo en el curso de una carrera de maratón en 1984 los niveles de CK en su sangre pasaron de 83 UI/lit antes de la carrera a 480 UI/lit al final de ésta.…”

Section: Tabla 1 Causas Más Frecuentes De Rabdomiolisisunclassified

Rabdomiolisis tras actividad física extenuante: A propósito de un caso

González¹

2005

Cuad. med. forense

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1 Médico Forense. RESUMEN Se presenta un caso de rabdomiolisis no complicada en un varón tras detención policial y estancia en comisaría durante 4 días. El detenido refirió malos tratos policiales consistentes en contusiones menores y exposición a actividad física extenuante. Se analizan las causas de rabdomiolisis descritas en la literatura médica y el curso natural de la enfermedad en los casos traumáticos. Se comprueba la posible relación entre ambos hechos: rabdomiolisis no complicada y mal trato físico. Se sugiere la posibilidad de introducir el estudio de mioglobina y enzimas musculares en sangre y orina como parte de los protocolos de diagnóstico de malos tratos físicos.

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“…Early case reports tell of asymptomatic marathon runners diagnosed with myocardial infarction based solely on findings of elevated creatinine kinase MB (CK-MB) fractions after race participation (1,2). The suspicion that these tests reflected non-specific detection of skeletal muscle rhabdomyolysis was supported by a study of muscle biopsies taken from human volunteers.…”

mentioning

confidence: 97%