Granular cell tumor (Abrikossoff's tumor) of the labium majus: a case report

Abstract

Granular Cell Tumor (GCT) is an uncommon, benign tumor of neural origin resembling Schwann cells. It is more common in females and blacks. Head and neck regions are the most sites involved by the tumor, but it can occur in any part of the body. Vulva, ovary and cervix in females and scrotum in males can present GCT. The importance of this tumor is potential malignant transformation in rarity. Total excision is the choice treatment for GCT because of probability of recurrences.In this article, we described a case of granular cell tumor of the labium majus in a 21-year old lady, from southwest of Iran. Subsequent investigations confirmed positive results for S100 protein and neuron specific enolase, but Periodic Acid Schiff (PAS) staining was negative.Our findings confirmed neural origin for GCT.

Abrikossoff's tumor of the penis: a case report

“…GCT was first described in 1926 by Abrikossoff [5], who called these tumors "granular cell myoblastomas, " suggesting that their origin was from skeletal muscle. Additional studies have demonstrated their close association with peripheral nerves [4]. Later, the use of electron microscopy and immunohistochemical techniques provided further evidence supporting the differentiation of Schwann cells from these tumors, which later became known as GCT.…”