Granular cell tumor in a premenstrual female breast

Omar, Lena; Pfeifer, Cory M.; Kulkarni, Samir; Sharma, Pooja; Sengupta, Anita; Kwon, Jeannie K.

doi:10.1016/j.clinimag.2018.09.003

Cited by 10 publications

(10 citation statements)

References 13 publications

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“…To the best of our knowledge, only 7 cases of breast GCT in children have been reported in the English literature (Table1). 7 - 13 Our case is the youngest of the 7 reported cases. While most of the reported cases presented with a unilateral painless breast mass, our patient presented with a unilateral painful breast mass, with the pain likely attributed to ulceration of the skin, which is usually not seen in breast GCT (Table 1).…”

Section: Discussionmentioning

confidence: 69%

Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group

et al. 2019

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Granular cell tumor (GCT) is a rare soft tissue neoplasm of Schwann cell origin. Most cases occur in adults; however, the precise incidence is unknown in children. GCT is usually a slow-growing, painless tumor involving the skin and soft tissues that is mostly located in the head and neck region, especially the tongue. The breast is one of the least common sites involved by GCT. This paper presents a 3-year-old girl who presented with a soft to firm, ill-defined swelling on the right breast with painful ulceration of the overlying skin. Fine needle aspiration rendered an initial diagnosis of fibrocystic change accompanied by apocrine metaplasia. Histologic evaluation of the excised breast mass revealed a benign granular cell tumor. Although rare, GCT of the breast should be included in the differential diagnosis for breast masses in pediatric patients. Proper diagnosis and timely management of this tumor are essential because of its malignant potential (<2% of cases) and high rate of local recurrence if not properly excised.

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Section: Discussionmentioning

confidence: 69%

Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group

et al. 2019

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“…Granular-cell changes have also been found in association with mastectomy scars (3,6) . Although most reported cases of GCT have been in women, especially those who are premenopausal (despite the fact that the tumor is not hormone-dependent) or Black (7) , it can occur (rarely) in males (8) . The presentation of a GCT is as a painless solid nodule that is usually firm on palpation and has a diameter of less than 3 cm.…”

Section: Discussionmentioning

confidence: 99%

Granular cell tumor of the breast: correlations between imaging and pathology findings

Abreu

Filipe²,

André³

et al. 2020

Radiol Bras

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Objective: To review the imaging features of granular cell tumors of the breast (on mammography, ultrasound, and magnetic resonance imaging), establishing a pathological correlation, in order to familiarize radiologists with this entity and make them aware of the differential diagnoses, other than malignancy, of lesions with spiculated margins. Materials and Methods: We reviewed the medical records (from a clinical-pathology database and picture archiving and communication system) of five patients with a pathologically confirmed diagnosis of granular cell tumor of the breast, treated at the Portuguese Oncology Institute of Lisbon, in the city of Lisbon, Portugal, between January 2012 and December 2018. Results: All five tumors exhibited imaging features highly suggestive of malignancy (BI-RADS 5 lesions), namely spiculated margins, significant depth, and posterior acoustic shadowing (on ultrasound). One tumor showed a kinetic curve indicative of washout on magnetic resonance imaging, two were adherent to the pectoralis muscle, and one was accompanied by skin retraction. Pathology provided the definitive diagnosis in all cases. Conclusion: Granular cell tumors of the breast pose a diagnostic challenge because they can present with clinical and imaging features mimicking malignancy, and the diagnosis is therefore provided by pathology. Radiologists should be familiarized with this entity, so they can be aware of the fact that breast lesions with spiculated margins can be indicative of diagnoses other than malignancy.

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“…[ 4 ] The youngest case of GCTB was pertained to 9-year-old patient. [ 5 ] GCTB is usually benign, although 1% cases can be malignant and 10% cases can be associated with breast cancer. Most cases of GCTB are incidentally found in painless masses, especially in the subcutaneous area, that have a hard texture, an unclear border, slow growth and are adhered to the skin.…”

Section: Discussionmentioning

confidence: 99%

Imaging features of granular cell tumor in the breast

et al. 2020

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Rationale: Granular cell tumor of the breast (GCTB) is a benign rare tumor. There are limited reports on its imaging manifestations. GCTB is often misdiagnosed as breast cancer, which results in unnecessary radical mastectomy and excessive treatment. In this article, we have reported a case of a 56-year-old postmenopausal woman with GCTB and highlighted the imaging features to differentiate this rare tumor from breast cancer. Patient concerns: A 56-year-old postmenopausal patient had a chief complaint of a subcutaneous nodule in the upper outer quadrant of her right breast for 2 months. She underwent physical examination, color Doppler ultrasonography, mammography, magnetic resonance, and postoperative pathology. Diagnoses: The final diagnosis was GCTB. The tumor cells were intermingled with the fibrous stroma and normal breast parenchyma and showed positive immunoreaction to S-100, CD68, and neuron-specific enolase. Interventions: The patient underwent lumpectomy and sentinel lymph node biopsy. Outcomes: The patient recovered well after lumpectomy and had no complications during the 2-year follow-up. Lessons: There are some important imaging features of GCTB that can be used to distinguish it from breast carcinoma to reduce misdiagnosis.

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Granular cell tumor in a premenstrual female breast

Cited by 10 publications

References 13 publications

Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group

Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group

Granular cell tumor of the breast: correlations between imaging and pathology findings

Imaging features of granular cell tumor in the breast

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