Granular cell tumor of penis and scrotum

Granular Cell Tumor in the Testis of a Rabbit: Cytologic, Histologic, Immunohistochemical, and Electron Microscopic Characterization

“…15,19,23,26 In postnatal animals and humans, GCT may occur in the genital tract, including the vulva, clitoris, vagina, cervix, and/or uterus of cats, rodents, and/or humans, and in the skin of the penis and scrotum of humans. 5,7,16,19 Although GCT has not been reported in the testes of animals or postnatal humans, it occurred in the testes of a 29-week-old human fetus with GCT in multiple tissues. 25 A unique characteristic of GCT is the presence of numerous secondary lysosomes when examined by transmission electron microscopy (TEM).…”

Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases

“…Tanaka et al [16] reported a GCT located in the base of the penis under the tunica albuginea within the substance of the corpus cavernosum. Bryant [11] reported simultaneous presentation of GCTs involving the penis and scrotum. All tumors presented as asymptomatic lesions with gradual, continued growth reported in 3 cases.…”

“…All tumors presented as asymptomatic lesions with gradual, continued growth reported in 3 cases. The microscopic description available for 7 of the tumors [11,14,[16][17][18][19][20] indicated that all of them exhibited conventional histology and possessed no atypical features.…”

“…With the exception of 2 cases where the race of the individual was not provided [17,19], the men were white (n = 4) [11,13,18,20], black (n = 2) [14,15], or Asian (n = 1) [16]. Eight tumors arose in the superficial tissues of the penile shaft (n =3), glans (n= 2), corona (n =2), and prepuce (n= 1) and ranged in size from 1.5 to 25.0 mm (mean, 7.8 mm; median, 3.5 mm).…”

“…Most GCTs reported in this anatomic region arose in the superficial tissues of the vulva and clitoris with nearly 60 examples of GCT documented in case reports and series (PubMed). In comparison, GCT of the male external genital tract is infrequently reported with only 3 scrotal [11,12] and 9 penile GCTs [11,[13][14][15][16][17][18][19][20] documented in the Englishlanguage literature.…”