Granular cell tumor of the tongue

Beemster, G.; Kwast, W.A.M. van der; Schoen, Jonathan; Waal, I. van der

doi:10.1016/s0300-9785(79)80007-1

Cited by 9 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Between January 1973 and January 1988, 15 cases of a granular cell tumor in the oral cavity have been seen in the Departments of Oral Pathology and Oral Surgery of the Teaching Hospital of the Free University of Amsterdam. Thirteen of these granular cell tumors were located in the anterior two-thirds of the tongue, five of them have been previously reported (6). The data are summarized in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Morphometric study of pseudoepitheliomatous hyperplasia in granular cell tumors of the tongue

Wai

Baak

Schipper

et al. 1989

J Oral Pathology Medicine

View full text Add to dashboard Cite

Several reports have mentioned the possibility of misdiagnosing pseudoepitheliomatous hyperplasia (PEH) of the overlying mucosa of a granular cell tumor as a squamous cell carcinoma (SCC). Because of this, morphometry was applied to five granular cell tumors with PEH and five well-differentiated SCC of the tongue. In addition, ten normal tongues have been examined. The mean area, the mean perimeter and the mean diameter of the 50 largest squamous epithelial nuclei in 50 fields were found to be significantly larger in squamous cell carcinomas than in granular cell tumors and normal tongues. The shape factor of the nucleus and the mitotic activity appeared to be of no significant value in this respect.

show abstract

Section: Methodsmentioning

confidence: 99%

Morphometric study of pseudoepitheliomatous hyperplasia in granular cell tumors of the tongue

Wai

Baak

Schipper

et al. 1989

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…Granular cell tumour is a, initially benign, connective neoplastic lesion that originates from Schwann cells and is S100 (+) (Allen et al, ). Multiple studies (Apisarnthanarax, ; Beemster, Van Der Kwast, Schoen, & Van Der Waal, ; Eguia et al, ; van del Loo et al, ) have described small series of intraoral GCT, but this study collects the greatest number of cases to date.…”

Section: Discussionmentioning

confidence: 96%

“…The low prevalence of this neoplasm, as well as its location and its non‐specific clinical appearance, provokes the low degree of clinical diagnosis success, favouring other presumptive diagnoses such as reactive hyperplasic connective lesions (Beemster et al, ), benign neoplasms like lipomas (Apisarnthanarax, ) or schwannomas (Serpa, Costa‐Neto, Oliveira, Silveira, & Medeiros, ), salivary gland tumours (Nagaraj et al, ) and malignant lesions like squamous cell carcinoma (SCC) (Ferreira, Oton‐Leite, Guidi, & Mendonça, ; Said‐Al‐Naief, Brandwein, Lawson, Gordon, & Lumerman, ; Zahid & Cariappa, ). It is very important to perform a good preoperative presumptive diagnosis, since the clinical suspicion of GCT determines whether the biopsy is incisional or excisional, in each case.…”

Section: Discussionmentioning

confidence: 99%

“…Another interesting fact about this pathology is the small of cases (2.4%) that recur (Beemster et al, ; Fliss, Puterman, Zirkin, & Leiberman, ; Lamey, Rennie, & James, ; van de Loo et al, ; Seki et al, ), which has been related to poor deep margin excision (Lack et al, ). We believe that the granular cells that remain would maintain their growing potential and trigger the recurrence.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oral granular cell tumour: A multicentric study of 56 cases and a systematic review

et al. 2020

View full text Add to dashboard Cite

Objective Granular cell tumour (GCT) is a benign neoplasm that originates from Schwann cells. Within the oral cavity, it usually appears as a lingual nodule and especially amongst female adults. Histologically, GCT shows a proliferation of polygonal cells with eosinophilic granular cytoplasm, which can be associated with a pseudoepitheliomatous hyperplasia (PEH). In this study, we analyse the main clinicopathological data of intraoral GCT and we compare our results with previous studies. Material and Methods We have studied a series of 56 cases of oral GCT in Spain and Brazil, and we have conducted a systematic review in PubMed, Web of Knowledge and Scopus databases, using the keywords: “granular cell tumour” and oral. Results In our series, GCT appeared as an asymptomatic benign tumour that is more frequent in women and in the tongue. PEH was observed in 32% of the lesions. In the review, we collected 282 cases of oral GCT with a similar clinical profile; seven patients had multiple lesions, and 33% of the cases presented PEH. No cases of malignant oral GCT have been described to date. GCT is an uncommon oral benign neoplasm, mainly unique and asymptomatic, derived from Schwann cells. Conclusions Although the etiopathogenesis of this oral tumour is unknown, its characteristics suggest that it could have a reactive nature. Conducting a complete clinicopathological study in all intraoral GCT is fundamental in order to dismiss other entities, including oral carcinoma.

show abstract