Morphometric study of pseudoepitheliomatous hyperplasia in granular cell tumors of the tongue

Wai, N.; Baak, J. P. A.; Schipper, N. W.; Waal, I. van der

doi:10.1111/j.1600-0714.1989.tb00723.x

Cited by 25 publications

(6 citation statements)

References 5 publications

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“…On the whole, among the quantitative morphometric parameters of the nuclei analyzed in this study, nuclear area and nuclear perimeter were significantly larger in pN-positive cases than in pN-negative cases, while the nuclear circular rate was lower in pN-positive cases but not significantly so. These results suggest that malignant nuclei become aspherical, which would be consistent with previous reports [8] , [35] – [42] . Regarding the patient’s age, however, it has been reported that low age (<42 years) was associated with the development of cervical lymph node metastasis within a short time frame (≤50 days) [45] .…”

Section: Discussionsupporting

confidence: 93%

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Applicability of Preoperative Nuclear Morphometry to Evaluating Risk for Cervical Lymph Node Metastasis in Oral Squamous Cell Carcinoma

et al. 2014

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BackgroundWe previously reported the utility of preoperative nuclear morphometry for evaluating risk for cervical lymph node metastases in tongue squamous cell carcinoma. The risk for lymph node metastasis in oral squamous cell carcinoma, however, is known to differ depending on the anatomical site of the primary tumor, such as the tongue, gingiva, mouth floor, and buccal mucosa. In this study, we evaluated the applicability of this morphometric technique to evaluating the risk for cervical lymph node metastasis in oral squamous cell carcinoma.MethodsA digital image system was used to measure the mean nuclear area, mean nuclear perimeter, nuclear circular rate, ratio of nuclear length to width (aspect ratio), and nuclear area coefficient of variation (NACV). Relationships between these parameters and nodal status were evaluated by t-test and logistic regression analysis.ResultsEighty-eight cases of squamous cell carcinoma (52 of the tongue, 25 of the gingiva, 4 of the buccal mucosa, and 7 of the mouth floor) were included: 46 with positive node classification and 42 with negative node classification. Nuclear area and perimeter were significantly larger in node-positive cases than in node-negative cases; however, there were no significant differences in circular rate, aspect ratio, or NACV. We derived two risk models based on the results of multivariate analysis: Model 1, which identified age and mean nuclear area and Model 2, which identified age and mean nuclear perimeter. It should be noted that primary tumor site was not associated the pN-positive status. There were no significant differences in pathological nodal status by aspect ratio, NACV, or primary tumor site.ConclusionOur method of preoperative nuclear morphometry may contribute valuable information to evaluations of the risk for lymph node metastasis in oral squamous cell carcinoma.

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Section: Discussionsupporting

confidence: 93%

“…Size and contour irregularities of the nuclei are important features in the grading of OSCC [35] – [40] . Furthermore, it was reported that the nuclear size was larger in proportion to the grade of malignancy [41] , [42] .…”

Section: Discussionmentioning

confidence: 99%

Applicability of Preoperative Nuclear Morphometry to Evaluating Risk for Cervical Lymph Node Metastasis in Oral Squamous Cell Carcinoma

et al. 2014

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“…In the present study, computerized image analysis of nuclear morphometric features like area, minimum diameter, and perimeter showed an increase in histological sections of OSCC as compared to normal buccal mucosa (control) in concordance with the study by van der Wal et al and Kinoshita et al [ 9 , 15 ].…”

Section: Discussionsupporting

confidence: 92%

“…Nuclei of epithelial tumor cells with well demarcated, clean, and nonoverlapping borders with absence of pyknosis were selected. The selected nuclei were assessed for the following features: nuclear diameter (in microns), nuclear area (in square microns), nuclear perimeter (in microns), and shape description (circularity graded on scale of 0 {a line}-1 {a circle}) [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

Prognostic Efficacy of Nuclear Morphometry at Invasive Front of Oral Squamous Cell Carcinoma: An Image Analysis Microscopic Study

Vedam

Boaz

Natarajan

2014

Analytical Cellular Pathology

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Background. Oral cancer is revisited on a pathologist perspective with advanced imaging technique. Objective. The present study assessed the new malignancy grading system at tumor proper (TP) and Bryne's grading system at invasive tumor front (ITF), morphometric features using software, to clarify their associations with prognosis of oral cancers. Methods. Histologically confirmed oral squamous cell carcinoma (OSCC) with 5-year follow-up was assessed morphometrically using image analysis at TP and ITF, correlated with the prognosis of patient. Results. On comparison of grading systems, a moderate agreement between both (Bryne and Anneroth) was seen. Among all histological parameters, we noted inverse correlation between degree of mitosis at invasive front and decrease in lymphoplasmacytic infiltrate at ITF with increase rate of recurrence and event of death. An increase in nuclear area, diameter, and perimeter along with decrease circularity in advancing OSCC was seen. Correlation of parameters showed higher values for maximum nuclear diameter, perimeter, and circularity at TP and ITF with recurrence. Conclusion. This study, while limited in sample size, concluded that a combined assessment of clinical TNM staging, histopathological grading system {excluding the parameter “mitotic activity” (due to its inverse relation)}, and nuclear morphometry at the ITF are better prognosticators. This combination proved to be an accurate predictive factor in eliciting the varied molecular characteristics of tumor heterogeneity.

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“…[1213] NF was found to be less in carcinoma groups than normal mucosa, suggesting that irregular or elliptical nuclei predominate in the carcinoma groups. Though NF reduced as grades of carcinoma increased, the difference was not statistically significant between carcinoma groups 2 and 3.…”

Section: Discussionmentioning

confidence: 98%

Nuclear features in oral squamous cell carcinoma: A computer-assisted microscopic study

Nandini

Subramanyam

2011

J Oral Maxillofac Pathol

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Background and Objectives:Oral squamous cell carcinoma (OSCC) is one of the most common tobacco-related cancers affecting the Indian population. Various malignancy-grading systems based on different histopathological features have been proposed for OSCC. Due to inherent subjectivity, inter-observer variation and reproducibility of a grading system remains a problem. Grading systems based on nuclear morphometry have been proposed for laryngeal, renal and pharyngeal carcinomas. In this study, an attempt was made to grade oral OSCC based on computer-assisted microscopic evaluation of nuclear features. Our intention was also to evaluate the use of Feulgen stain for studying nuclear features.Materials and Methods:Sections made from buccal mucosa biopsies of normal mucosa as well as different grades OSCC were stained by Feulgen reaction. The nuclear features were evaluated by computer-assisted microscopic image analysis for nuclear area (NA), nuclear perimeter (NP) and nuclear form factor (NF) and correlated with histologic grading of OSCC. Nuclear shape, membrane outline, chromatin clumps, nucleoli, and abnormal mitoses were also evaluated.Results:NA and NP were observed to be significantly increased in OSCC (P < 0.001) when compared with the control group. These values increased in correlation with increasing grades of OSCC. However, NF was found to more in the control group (P < 0.001).Conclusion:It may be concluded from the results that computer-assisted nuclear morphometry is a reliable tool for grading OSCC. A new grading system based on nuclear features for OSCC has been proposed.

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Morphometric study of pseudoepitheliomatous hyperplasia in granular cell tumors of the tongue

Cited by 25 publications

References 5 publications

Applicability of Preoperative Nuclear Morphometry to Evaluating Risk for Cervical Lymph Node Metastasis in Oral Squamous Cell Carcinoma

Applicability of Preoperative Nuclear Morphometry to Evaluating Risk for Cervical Lymph Node Metastasis in Oral Squamous Cell Carcinoma

Prognostic Efficacy of Nuclear Morphometry at Invasive Front of Oral Squamous Cell Carcinoma: An Image Analysis Microscopic Study

Nuclear features in oral squamous cell carcinoma: A computer-assisted microscopic study

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