Granular cell tumour of the hand

Korambayil, Pradeoth Mukundan

doi:10.4103/0970-0358.96600

Cited by 4 publications

(18 citation statements)

References 3 publications

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“…The common sites of predilection are tongue, skin and subcutaneous tissue. Other less common sites are nerve, breast, scalp, abdominal wall, back, extremities, inguinal region, lymph node, mediastinum, soft palate, orbit, salivary glands, respiratory tract, vulva and GIT [1][2][3][4][5] In the skin, it usually presents as single, painless, mobile, well circumscribed, slow growing, skin coloured, pink or greyish, firm or hard nodule with smooth or hyperkeratotic surface located in dermis or subcutaneous layer [1,2]. Its size varies between 5 mm-30 mm with a tendency to regress partially over the time.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical picture is usually simulated by dermatofibroma, f i b r o x a n t h o m a , l i p o m a , ke r a t o a c a n t h o m a , neurofibroma, leiomyoma and leiomyosarcoma which needs to be ruled out on histopahologic evaluation [1][2][3][4]. On histopathology, H & E staining of sample of GCT of skin characteristically reveal non-encapsulated, irregular sheets of large round or polygonal cells with indistinct cytological borders containing abundantly eosinophilic, granular, pale staining cytoplasm and centrally or eccentrically located small, round or oval nuclei with fine chromatin and inconspicuous nucleoli [2][3][4]8].…”

Section: Discussionmentioning

confidence: 99%

“…GCT is an uncommon tumour of Schwann cell origin with an incidence of 0.017%-0.029%, first described by Abrikossoff as granular cell myoblastoma in 1926 [1][2][3][4]. It most commonly occur in tongue but can occur at any other sites presenting as an asymptomatic, solitary, flesh coloured, firm or hard nodule in middle aged persons [1].…”

Section: Introductionmentioning

confidence: 99%

“…It most commonly occur in tongue but can occur at any other sites presenting as an asymptomatic, solitary, flesh coloured, firm or hard nodule in middle aged persons [1]. In few cases,it can be multiple and rarely, malignant transformation has also been reported.…”

Section: Introductionmentioning

confidence: 99%

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Granular cell tumour: An uncommon tumour of Schwann cell origin

Tiwary¹,

Lal²,

Mishra³

2016

Our Dermatol Online

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Granular cell tumour: An uncommon tumour of Schwann cell origin

Tiwary¹,

Lal²,

Mishra³

2016

Our Dermatol Online

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“…[4–8] Though the most common site of involvement is the tongue, it can occur anywhere in the body. [3–59] A GCT usually presents as a small solitary painless firm nodule affecting the middle-aged people. [3–5681011] The GCT of hand is exceedingly rare with only 17 cases bieng reported in the literature till date.…”

Section: Introductionmentioning

confidence: 99%

Granular cell tumor of hand presenting as subcutaneous nodule mimicking dermal adnexal tumor: A diagnosis by cytology

Nasit

Chauhan

Dhruva

2013

Indian Dermatol Online J

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Granular cell tumor (GCT) is an uncommon tumor and is believed to be of schwannian origin. GCT is benign but rare malignant cases are recorded. GCT occurs in almost any part of the body. The common sites are the tongue, skin, and subcutaneous tissue. GCT of hand is an extremely rare. Till date only 17 cases are reported in the literature. Preoperative diagnosis of GCT is important, because GCT mimics dermal adnexal tumor in subcutaneous tissue, other soft tissue tumor or inflammatory lesions. GCT is composed of large polygonal cells with eosinophilic granular cytoplasm and these cells are often immunoreactive for the S-100 protein. Fine-needle aspiration cytology has been suggested to be diagnostic modality of choice and this would undoubtedly aid the correct diagnosis. Excision with wide surgical margins is curative for benign GCT. Recurrence and malignant transformation requires regular follow-up. Here, this communication documents a case of cytological diagnosis of the granular cell tumor of hand in a 21-year-old female, clinically suspected to be a dermal adnexal tumor.

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Features of atypical granular cell tumor on fine needle aspiration in an 8-month-old child: a case report

Miličić

Prvulović²,

Perić

et al. 2014

CRCP

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Granular cell tumors (GCT) are uncommon, generally benign soft tissue neoplasms that can affect virtually any site of the body, the most common locations being tongue, breast, upper respiratory tract, skin and soft tissues of upper extremities. Most patients are middle-aged, with a peak incidence in the fourth to sixth decade of life. GCT commonly presents as an asymptomatic slowly growing, painless nodule. Atypical and malignant counterparts are rare. Herein, we report on the case of an atypical GCT in an 8-months-old baby who presented at our Department with well-defined papulomatous lesion of one month duration on his back. A solitary, firm, painless nodule, about 1.5 cm in size was found on clinical examination. Fine needle aspiration cytology (FNAC) of the lesion was performed using a 22-gauge needle. Smears were stained with May-Grunwald-Giemsa and Papanicolaou stain. Cytomorphology revealed highly cellular tumor composed of loosely dispersed group of cells and stripped bare nuclei. The cells were large, polygonal to spindle-shaped with an abundant eosinophilic granular and fragile cytoplasm and round to oval nucleus with fine chromatin pattern. Focally cells were larger with prominent nucleoli. Rare mitotic figures were present. Diagnosis of malignant mesenchymal tumor was suggested and excision was advised. Histological examination revealed tumor tissue composed of large, polygonal cells with granular eosinophilic cytoplasm, vesicular nuclei, moderate nuclear pleomorphism and focally prominent nucleoli. There were 2 mitosis per 10 HPF. The tumor cells were positive for S-100 and vimentin. A diagnosis of atypical GCT was established. In conclusion, benign GCT has a distinctive cytomorphologic appearance and can be diagnosed on the basis of the cytological examination alone. Nuclear pleomorphism, spindling of the cells, prominent nucleoli and mitotic figures are worrisome features that suggest malignancy and necessity of histological examination. Considering the patient's age and atypical morphology, to the best of our knowledge, there have been up to 15 GCT cases described in medical literature by now in the children less than one year.

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Granular cell tumour of the hand

Cited by 4 publications

References 3 publications

Granular cell tumour: An uncommon tumour of Schwann cell origin

Granular cell tumour: An uncommon tumour of Schwann cell origin

Granular cell tumor of hand presenting as subcutaneous nodule mimicking dermal adnexal tumor: A diagnosis by cytology

Features of atypical granular cell tumor on fine needle aspiration in an 8-month-old child: a case report

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