Granular cell variant of dermatofibrosarcoma protuberans

Abstract

Brief reports 375 References 3 . Davis 1. Shapiro L. Barall. Vulvitis circumscriota ~l a s m a cellularis. . . . . /. Am. Acad. ofDermatol. 1983: 8: 413-416. 4. Lauchlan SC. Metaplasias and neoplasias of Mullerian epithelium. Histopathology 1984: 8: 543-557. 5, Fox H, Wells M, Harris M, McWilliam LJ, Anderson G S . Enteric tumours of the lower female genital tract. Histopathology 1988: 12: 167-1 76. 1. Culling CFA. Reid PE. Burton ID, Dunn wL. A histochemical method of differentiating lower gastrointestinal mucin from other mucins in primary or metastatic tumours. 1. Clin. Pathol. 1975: 28: 656-658. 2. Mensing H. Janner M. Vulvitis plasma cellularis Zoon. 2. Hautkr.

Granular cell dermatofibroma

“…It is very likely that, as in our series, similar lesions are filed as classic granular cell tumour, or probably even misread as other granular cell entities. And indeed, the illustration of the second case of granular dermatofibrosarcoma protuberans by Banerjee et al 12 reveals a granular exo-/endophytic lesion with sharp nodular demarcation and marked acanthosis, which could easily also be interpreted as a granular variant of deep penetrating dermatofibroma 13 . Unfortunately, in 1990 CD34 labelling had still not been established as a diagnostic marker of dermatofibrosarcoma protuberans 14 , nor was there any mention of factor XIIIa, smooth muscle specific actin, or E9.…”

Dermatofibroma with granular cells

“…In the first group it has been described in inflammatory processes, in areas of necrosis, in association with surgical trauma or other types of injury [6][7] . The latter group includes lesions such as dermatofibrosarcoma protuberans 8 , angiosarcoma of the skin 9 , basal-cell carcinoma 10 , benign and malignant smooth muscle and neural tumours, and other non-cutaneous tumours [11][12] . To our knowledge the only description of granular cell change in dermatofibroma is the abstract of the paper presented by Leboit and Barr at the 29th Annual Meeting of the American Society of Dermatopathology.…”

Granular cell atypical fibroxanthoma

“…include leiomyoma, schwannoma, dermatofibroma, angiosarcoma, leiomyosarcoma, basal cell carcinoma, dermatofibrosarcoma protruberans, atypical fibroxanthoma, 6,7,[8][9][10][11][12][13][14][15][16][17][18][19][20][21] and the classical granular cell tumor, including its rare malignant analog. Immunoperoxidase studies are often necessary in the evaluation of tumor phenotype because of the similarities of some of the neoplasms.…”