Granulicatella (Abiotrophia) adiacens Infection Associated with a Total Knee Arthroplasty

Riede, Ulf; Gräber, Peter; Ochsner, P. E.

doi:10.1080/00365540410021009a

Cited by 29 publications

(13 citation statements)

References 6 publications

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“…To the best of knowledge, eight cases have been published to date, including five cases of vertebral osteomyelitis [2, 8–10], one case of native arthritis [11] and two cases of prosthetic joint infection [12, 13]. Here we report three cases of prosthetic joint infection caused by G. adiacens treated in our center.…”

Section: Discussionmentioning

confidence: 94%

Prosthetic joint infection caused by Granulicatella adiacens: a case series and review of literature

Quénard

Seng

Lagier

et al. 2017

BMC Musculoskelet Disord

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BackgroundBone and joint infection involving Granulicatella adiacens is rare, and mainly involved in cases of bacteremia and infectious endocarditis. Here we report three cases of prosthetic joint infection involving G. adiacens that were successfully treated with surgery and prolonged antimicrobial treatment. We also review the two cases of prosthetic joint infection involving G. adiacens that are reported in the literature.Case presentationNot all five cases of prosthetic joint infection caused by G. adiacens were associated with bacteremia or infectious endocarditis. Dental care before the onset of infection was observed in two cases. The median time delay between arthroplasty implantation and the onset of infection was of 4 years (ranging between 2 and 10 years). One of our cases was identified with 16srRNA gene sequencing, one case with MALDI-TOF mass spectrometry, and one case with both techniques. Two literature cases were diagnosed by 16srRNA gene sequencing. All five cases were cured after surgery including a two-stage prosthesis exchange in three cases, a one-stage prosthesis exchange in one case, and debridement, antibiotics, irrigation, and retention of the prosthesis in one case, and prolonged antimicrobial treatment.ConclusionProsthetic joint infection involving G. adiacens is probably often dismissed due to difficult culture or misdiagnosis, in particular in the cases of polymicrobial infection. Debridement, antibiotics, irrigation, and retention of the prosthesis associated with prolonged antimicrobial treatment (≥ 8 weeks) should be considered as a treatment strategy for prosthetic joint infection involving G. adiacens.

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Section: Discussionmentioning

confidence: 94%

Prosthetic joint infection caused by Granulicatella adiacens: a case series and review of literature

Quénard

Seng

Lagier

et al. 2017

BMC Musculoskelet Disord

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“…Granulicatella also has the ability to bind to fibronectin, facilitating intravascular infections, including endocarditis [17]. Infections with Granulicatella have been reported in a wide variety of settings, including the central nervous system [20,24], joints [23,26], osteomyelitis [27], tubo-ovarian abscess [22], peritonitis [18,19], and a breast implant [21]. Resistance to beta-lactam and macrolide antibiotics has been described [28,29].…”

Section: Discussionmentioning

confidence: 99%

“…Many reported infections involved immunocompromised patients, and the most common infections were sepsis and endocarditis, with more than 20 such cases reported [14][15][16][17]. The organism also has been associated with meningitis, osteomyelitis, peritonitis, various abscesses, pneumonia, and severe infections of foreign bodies such as pacemaker wires or prosthetic valves [18][19][20][21][22][23][24][25][26][27]. A common pattern of reported cases of infection with this species are high pharmacologic failure rates and a high mortality rate [14,25].…”

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confidence: 99%

Granulicatella adiacensBacteremia in an Elderly Trauma Patient

Gardenier

Hranjec

Sawyer

et al. 2011

Surgical Infections

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Background: Granulicatella adiacens is a normal commensal of human mucosal surfaces, inhabiting the oral cavity and urogenital and gastrointestinal tracts and only rarely causing disease. These gram-positive cocci can be difficult to identify. Case report: We report a first case of bacteremia caused by Granulicatella adiacens in an elderly female trauma victim. The infection was diagnosed accurately, and the patient was treated successfully. Conclusion: Granulicatella adiacens may be a more important pathogen than thus far recognized because of a lack of adequate diagnostic resources. Standards for sensitivity testing are needed urgently.

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“…Sie konnten aber auch bei verschiedenen anderen invasiven Infektionen als Erreger nachgewiesen werden, z.B. Hirnabszess [1,14], Gelenkimplantatinfektion [10,18], Vaskulitis bzw. infiziertes Gefäßimplantat [12,22], bakteriämische Infektion bzw.…”

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