Granulicatella adiacens is a fastidious Gram-positive streptococcus that is linked with causing a variety of infections in immunocompromised hosts. These include endocarditis, bacteremia, osteomyelitis, and spontaneous bacterial peritonitis. We present a rare incidence of this bacterium causing a complex parapneumonic effusion in an immunocompetent host. An effective antibiotic regimen for treating infections caused by this bacterium includes ampicillin plus penicillin plus gentamicin but resistance to various classes of antibiotics has been reported. In conclusion, this organism can affect different systems in immunocompromised as well as immunocompetent hosts, and a high index of suspicion is required for its diagnosis.