Granulocyte Activation Induced by Intense Interval Running

Gray, A. B.; Telford, Rohan M.; Baker, H. Kent; Weldemann, M. J.

doi:10.1249/00005768-199205001-00382

Cited by 5 publications

(7 citation statements)

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“…During the final minute of the exercise bout at a work rate of 150 W, heart rate was also significantly lower in the trained subjects, at 127(13) v 161 (19) beatsmmin-(P < 0 01). The relative exercise intensity during the final exercise period was 69(7)% and 87(10)% of age predicted maximum heart rate for the trained and control group, respectively.…”

Section: Heart Rate At Rest and During Exercisementioning

confidence: 85%

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Effects of submaximal cycling and long-term endurance training on neutrophil phagocytic activity in middle aged men.

et al. 1996

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Section: Heart Rate At Rest and During Exercisementioning

confidence: 85%

“…A further venous blood sample was taken immediately after exercise. (6 6) 61-0 (8 8)t HR (beats-min-') pre-exercise 69 (14) 52 (8)* HR (beats-min-') post-exercise 161 (19) 127 (13)t Significant differences between trained and control subjects: *P<0 05 tP< 001.…”

Section: Blood Sampling and Exercise Protocolmentioning

confidence: 99%

Effects of submaximal cycling and long-term endurance training on neutrophil phagocytic activity in middle aged men.

et al. 1996

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“…On the other hand, it has been suggested that the second, delayed leucocytosis is mainly caused by the release of newly synthesized neutrophils from the bone marrow, initiated by the high cortisol and adrenaline levels accompanying exercise (Gray et al 1993;Pedersen 1997).…”

Section: Ar and Wbccmentioning

confidence: 99%

Active recovery and post-exercise white blood cell count, free fatty acids, and hormones in endurance athletes

et al. 2001

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Strenuous endurance exercise in fasted subjects is accompanied by increased plasma levels of catecholamines, leucocytosis, low insulin, and elevated plasma free fatty acids (FFA). Immediately after such exercise, plasma FFA may rise to high and potentially harmful levels, whereas the white blood cell count (WBCC) rapidly decreases towards or below baseline values. The present work investigated how active recovery (AR) for 15 min at 50% of maximal oxygen consumption (VO2max), after 60 min of uphill running at 83% of VO2max, influenced plasma FFA, lymphocyte, neutrophil, granulocyte, and monocyte count, as well as adrenaline, noradrenaline, insulin and cortisol concentrations until 120 min post-exercise. Thirteen endurance athletes participated in the study [24.2 (3.7) years, 1.82 (0.06) m, 76.7 (7.9) kg and VO2max 69.2 (6.8) ml min-1 kg-1]. In a randomized order, the subjects completed two sets of strenuous workouts, followed by either AR or complete rest in the supine position (RR). Compared with RR, AR strongly counteracted the rapid increase in plasma FFA 5 min post-exercise. The decreases in neutrophil and monocyte counts post-exercise were nullified by AR, and the cell count stayed above resting values throughout the observation period. AR also counteracted the rapid return of hormone concentration towards baseline levels. It would appear that active recovery at low intensity after strenuous exercise can maintain sufficient adrenergic activation to counteract the post-exercise drop in WBCC. However, in spite of keeping the catecholamine concentration high and insulin levels low, AR can also maintain a low plasma FFA concentration, probably because of the continued use of FFA in muscle. It remains to be elucidated whether the observed high FFA and low WBCC values after RR have a negative effect on health. If so, AR could be a preventive measure.

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“…Several of these studies showed an increase in CD11b expression after moderate-intensity cycling (26) and high-intensity running (11,14,31). Smith et al (26) found no change in CD16 expression, whereas Gray et al (11) observed a trend toward reduced CD16 expression. It is unknown whether the expression of other neutrophil surface receptors such as CD35 is affected by exercise.…”

mentioning

confidence: 99%

“…A few studies have examined alterations in neutrophil receptor expression after exercise (11,14,26,31). Several of these studies showed an increase in CD11b expression after moderate-intensity cycling (26) and high-intensity running (11,14,31).…”

mentioning

confidence: 99%

Changes in neutrophil surface receptor expression, degranulation, and respiratory burst activity after moderate- and high-intensity exercise

Peake¹,

Wilson²,

Hordern³

et al. 2004

Journal of Applied Physiology

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Intense exercise stimulates the systemic release of a variety of factors that alter neutrophil surface receptor expression and functional activity. These alterations may influence resistance to infection after intense exercise. The aim of this study was to examine the influence of exercise intensity on neutrophil receptor expression, degranulation (measured by plasma and intracellular myeloperoxidase concentrations), and respiratory burst activity. Ten well-trained male runners ran on a treadmill for 60 min at 60% [moderate-intensity exercise (MI)] and 85% maximal oxygen consumption [high-intensity exercise (HI)]. Blood was drawn immediately before and after exercise and at 1 h postexercise. Immediately after HI, the expression of the neutrophil receptor CD16 was significantly below preexercise values (P < 0.01), whereas MI significantly reduced CD35 expression below preexercise values (P < 0.05). One hour after exercise at both intensities, there was a significant decline in CD11b expression (P < 0.05) and a further decrease in CD16 expression compared with preexercise values (P < 0.01). CD16 expression was lower 1 h after HI than 1 h after MI (P < 0.01). Immediately after HI, intracellular myeloperoxidase concentration was less than preexercise values (P < 0.01), whereas plasma myeloperoxidase concentration was greater (P < 0.01), indicating that HI stimulated neutrophil degranulation. Plasma myeloperoxidase concentration was higher immediately after HI than after MI (P < 0.01). Neutrophil respiratory burst activity increased after HI (P < 0.01). In summary, both MI and HI reduced neutrophil surface receptor expression. Although CD16 expression was reduced to a greater extent after HI, this reduction did not impair neutrophil degranulation and respiratory burst activity.

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Granulocyte Activation Induced by Intense Interval Running

Cited by 5 publications

References 0 publications

Effects of submaximal cycling and long-term endurance training on neutrophil phagocytic activity in middle aged men.

Effects of submaximal cycling and long-term endurance training on neutrophil phagocytic activity in middle aged men.

Active recovery and post-exercise white blood cell count, free fatty acids, and hormones in endurance athletes

Changes in neutrophil surface receptor expression, degranulation, and respiratory burst activity after moderate- and high-intensity exercise

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