Granulocytic Leukemia, Rat

Gál, Ferenc; Sugár, J; Csuka, Orsolya

doi:10.1007/978-3-642-84110-1_4

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Focal areas representing hemorrhage and pigment-laden macrophages are present in the fibrotic area. cytic leukemia is typically accompanied by a high circulating leukocyte count and marked splenomegaly (Gal et al, 1990;Seki and Inoue, 1990). Based upon the cytomorphology of the neoplastic cells, granulocytic leukemia can be subclassified as mature or immature.…”

Section: Neoplastic Lesionsmentioning

confidence: 99%

“…It has a spontaneous rate of occurrence in C3H/He mice of up to 1% (Seki and Inoue, 1990) while it is extremely rare in other strains. As a systemic disease, granulocytic leukemia is typically accompanied by a high circulating leukocyte count and marked splenomegaly (Gal et al, 1990; Seki and Inoue, 1990). Based upon the cytomorphology of the neoplastic cells, granulocytic leukemia can be subclassified as mature or immature.…”

Section: Neoplastic Lesionsmentioning

confidence: 99%

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Histopathology of the Spleen

2006

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The spleen contains hematopoietic and lymphoid elements, is a primary site of extramedullary hematopoiesis, and removes degenerate and aged red blood cells as well as particulate materials and circulating bacteria from the blood supply. Lesions of this important component of the immune system may center on the red pulp, the white pulp or involve both compartments The spleen is the site of direct and indirect toxicity, a target for some carcinogens, and also a site for metastatic neoplasia. Many systemic or generalized diseases have splenic involvement. This paper documents spontaneous background and treatment-induced lesions seen in rodent toxicity and carcinogenicity studies.

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Section: Neoplastic Lesionsmentioning

confidence: 99%