Granuloma anular elastolítico gigantocelular: relato de caso

Gonçalves, Rossana Ruth da Veiga; Miranda, Milton Edson; Viana, Fernanda de Oliveira; Cavaleiro, Luíza Helena dos Santos; Fonseca, Diana Mendes da

doi:10.1590/s0365-05962011000700017

Cited by 3 publications

(3 citation statements)

References 6 publications

(14 reference statements)

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“…4 O granuloma actínico pode estar associado a diversas doenças, tais como a arterite temporal, a polimialgia reumática, a policondrite recidivante, o pseudoxantoma elás-tico1 e a diabetes mellitus. 2 Em relação ao tratamento, diversos são utilizados, como (,) antimaláricos, metotrexato, esteroides tópicos e sistêmicos, dapsona, clofazimina, re-PUVA, retinoides isolados, PUVA, excisão cirúrgica de lesões, crioterapia, pentoxifilina. [1][2][3][4][5] No caso que reportamos, o uso de hidroxicloroquina e clobetasol não foram eficientes para a melhora das lesões.…”

Section: Discussionunclassified

“…2 Em relação ao tratamento, diversos são utilizados, como (,) antimaláricos, metotrexato, esteroides tópicos e sistêmicos, dapsona, clofazimina, re-PUVA, retinoides isolados, PUVA, excisão cirúrgica de lesões, crioterapia, pentoxifilina. [1][2][3][4][5] No caso que reportamos, o uso de hidroxicloroquina e clobetasol não foram eficientes para a melhora das lesões. Optamos então pela introdução de griseofulvina por existirem relatos na literatura de sua ação anti-inflamatória, principalmente no tratamento de líquen plano 8 .…”

Section: Discussionunclassified

“…7 Histologicamente, evidenciam-se células gigantes multinucleadas, elastofagocitose, elastólise, sem deposição de mucina ou necrobiose do colágeno. 2,7 Apesar de existirem diversos tipos de tratamento, tais como ciclosporina, retinóides, antimaláricos, esteroides intralesionais, metotrexato, dapsona, etc, 4 ele continua bastante desafiador, pela resposta variável que cada paciente apresenta a determinado tipo de terapêutica.…”

Section: Introductionunclassified

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Utilidade Da Griseofulvina No Tratamento Do Granuloma Actínico De O’brien

Tonin

Pereira

Rezende

et al. 2016

SPDV

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O granuloma actiníco de O’Brien, ou também chamado de granuloma anular elastolítico de células gigantes é uma afecção rara. Apresenta-se clinicamente como pápulas que se confluem formando lesões anulares com centro atrófico. Histologicamente, evidencia-se elastofagocitose e elastólise. O seguinte caso relata uma paciente com 53 anos, que apresentava lesões clínicas e histopatológicas clássicas de granuloma actínico que evoluiu com melhora importante no tratamento adjuvante com griseofulvina.

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Section: Discussionunclassified

Section: Introductionunclassified

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Utilidade Da Griseofulvina No Tratamento Do Granuloma Actínico De O’brien

Tonin

Pereira

Rezende

et al. 2016

SPDV

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Elastolytic Actinic Giant Cell Granuloma

Gutiérrez‐González

Pereiro

Toribio

2015

Dermatologic Clinics

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Photodistributed granuloma annulare

Gittler

Mir

Meehan

et al. 2015

Dermatology Online Journal

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Annular elastolytic giant cell granuloma (AEGCG) is a controversial entity that is considered by many to be a variant of granuloma annulare (GA). The majority of cases of AEGCG occur in Caucasian women (3:2) between the ages of 40 and 70, with the distribution of the mostly annular lesions favoring exposed areas of skin and rarely involving covered skin. The most common systemic association has been with diabetes mellitus. We present a 52-year-old woman with an asymptomatic, annular, erythematous, photodistributed eruption of two-years duration. As part of her evaluation, it was detected that she had a hemoglobin A1C of 10.3% and a diagnosis of diabetes mellitus was made. We review the literature on the clinical and histopathologic features of GA and AEGCG and the overlap between these entities. Case synopsisHistory: A 52-year-old woman presented to the Skin and Cancer Unit for evaluation of an asymptomatic eruption of two-years duration. Around the time of experiencing stress, she first developed erythematous papules on her right forearm and the dorsal aspect of the right hand that persisted despite treatment with a topical glucocorticoid. Several months prior to presentation, after another stressful life event, the eruption appeared on her dorsal aspect of the left hand and forearm and later spread to her upper chest. The eruption remained asymptomatic. At the time of presentation, she denied recent sun exposure, although she reported sun exposure as a child. She noted many sunburns and inability to tan. The patient denied fever, chills, nausea, vomiting, and diarrhea. She reported recent weight gain. Physical examination:On the dorsal aspects of the hands, forearms, and upper chest were annular, erythematous, thin papules and plaques. Laboratory data:A complete blood count, anti-nuclear antibody, anti-Ro antibody, anti-La antibody, and serum protein electrophoresis were normal or negative. Comprehensive metabolic panel showed glucose of 216 mg/dL and aspartate transaminase and alanine transaminase of at 110 and 108 U/L, respectively. Hemoglobin A1C was at 10.3%. Histopathology:There is a nodular infiltrate of histiocytes, some of which are multinucleated, that surround foci of degenerated collagen and increased connective tissue mucin, as demonstrated by a colloidal-iron stain.

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Granuloma anular elastolítico gigantocelular: relato de caso

Cited by 3 publications

References 6 publications

Utilidade Da Griseofulvina No Tratamento Do Granuloma Actínico De O’brien

Utilidade Da Griseofulvina No Tratamento Do Granuloma Actínico De O’brien

Elastolytic Actinic Giant Cell Granuloma

Photodistributed granuloma annulare

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