Granuloma Periférico de Células Gigantes e Hiperparatiroidismo. Presentación de un Caso

Abstract

ALARCÓN, A.; MUÑOZ, R. M.; SCHNETTLER, K. & ULLOA, M. C. Granuloma periférico de células gigantes e hiperparatiroidismo. presentación de un caso. Int. J. Odontostomat., 13(3):266-270, 2019. RESUMEN:Se presenta el caso de un paciente sexo femenino 31 años, insuficienciente renal crónica en hemodiálisis, hipertensa secundaria, consulta por aumento de volumen oral en relación a encía marginal vestibular izquierda, 6 meses de evolución. Al examen se observa aumento de volumen de 15 mm en relación a piezas. 3.6 y 3.7. Radiografía muestra compromiso periodontal pieza 3.7. Se realiza biopsia excisional y exodoncia pieza 3.7. Histopatología informa granuloma periférico de células gigantes. Se solicitan exámenes de laboratorio para estudio de hiperparatiroidismo (PTH elevada, calcemia fosfatemia normales). Evoluciona favorablemente. Sin signos de recidiva a los 3 meses. El diagnóstico histopatológico de lesión de células gigantes debe ser complementado con la clínica, exámenes de laboratorio e imagenología, el objetivo final es definir si tal diagnóstico corresponde a un tumor pardo, a un granuloma central de células gigantes o a un granuloma periférico de células gigantes. En la literatura los reportes de asociación entre granuloma periférico de células gigantes e hiperparatiroidismo son escasos. Este caso corresponde a granuloma periférico células gigantes, asociado a hipersecreción de paratohormona.PALABRAS CLAVE: granuloma periférico, células gigantes. hiperparatiroidismo. insuficiencia renal crónica.

Peripheral Giant Cell Granuloma in Pregnancy: A Case Report

“…The treatment of choice for PGCG is surgical excision, as implemented in the present clinical case and in previous studies [1,7,14,27]. This surgical removal method involves excising the lesion along with extensive curettage of the periosteum at the base of the lesion.…”

“…The complexity of the etiology of GPCG involves several hypotheses of reactive processes, the nature of multinucleated giant cells, and the influence of cytokines and differentiation factors [1,4,[13][14][15]. GPCG is generally considered a reactive lesion, which means that it is probably triggered by external factors such as the presence of local irritants such as dental biofilm, dental calculus, overflowing restorations, indiscriminate use of toothpicks, chronic infections, food, and tooth impaction [1,4,[13][14][15].…”

“…The complexity of the etiology of GPCG involves several hypotheses of reactive processes, the nature of multinucleated giant cells, and the influence of cytokines and differentiation factors [1,4,[13][14][15]. GPCG is generally considered a reactive lesion, which means that it is probably triggered by external factors such as the presence of local irritants such as dental biofilm, dental calculus, overflowing restorations, indiscriminate use of toothpicks, chronic infections, food, and tooth impaction [1,4,[13][14][15]. One theory of the nature of the multinucleated giant cells in GPCG proposes that they are osteoclasts, possibly residual from physiological tooth resorption or in reaction to injury to the periosteum; evidence supporting this includes the presence of receptors for calcitonin in these cells and their ability to excavate bone in vitro [4].…”

Pregnancy-Associated Peripheral Giant Cell Granuloma: A Case Report

“…The treatment of choice for PGCG is surgical excision, as implemented in the present clinical case and in previous studies [1,7,25,26]. This surgical removal method involves excising the lesion along with extensive curettage of the periosteum at the base of the lesion.…”