Granulomatous Diseases Affecting Jaws

Reddy, Baddam Venkat Ramana; Kuruba, Kiran Kumar; Samatha, Y; Mupparapu, Mel

doi:10.1016/j.cden.2015.08.007

Cited by 2 publications

(5 citation statements)

References 146 publications

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“…The normal serum calcium and alkaline phosphatase levels found in this case ruled out hyperparathyroidism. In aneurysmal bone cyst and other such lesions, giant cells are found close to areas of hemorrhage;[1617] whereas in this case, the giant cells were evenly distributed throughout the lesion. Histopathologically, the even distribution of giant cells throughout the cellular stroma composed of nonreactive, spindle-shaped fibroblastic stromal cells, the giant cells with evenly distributed nuclei close to 25–50, fresh regions of hemorrhage with hemosiderin deposits, inflammatory cell aggregates, and areas of fibrosis and reactive bone formation, all led to the final diagnosis being made in favor of CGCG of the mandible.…”

Section: Discussionmentioning

confidence: 87%

“…The common aspect of all granulomatous diseases is the typical form of chronic inflammatory response with distinct microscopic granulomas that are formed secondary to either definitive etiologic agents, such as bacteria, fungal, or parasitic, or due to unknown etiologic agents, such as trauma, autoimmune, or even neoplastic processes. [16] Two types of granulomas are typically encountered: foreign body granulomas and immune granulomas, the differences between them lying in their pathogenesis. The absence of any infective element or inflammatory component in our case as evidenced both by general clinical examination and blood investigations as well as microscopic evaluation of the biopsy specimen, ruled out the above.…”

Section: Discussionmentioning

confidence: 99%

“…Certain metabolic disorders such as hyperparathyroidism are also characterized by masses of reactive osteoclast-like giant cells, which histopathologically mimic GCTs of bone. [16]…”

Section: Discussionmentioning

confidence: 99%

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Management of central giant cell granulomas of the jaws: An unusual case report with critical appraisal of existing literature

Jeyaraj¹

2019

Ann Maxillofac Surg

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Central giant cell granuloma (CGCG) is an uncommon, benign but aggressive osteolytic neoplasm of the craniomaxillofacial region, histologically characterized by an abundance of evenly distributed multinucleated giant cells within a sea of spindle-shaped mesenchymal stromal cells, scattered throughout the fibrovascular connective tissue stroma containing areas of hemorrhage. A rapid diagnostic assessment, together with an adequate histopathologic verification, is essential to improve the management and the prognosis of this locally destructive lesion. A rare case of a large destructive CGCG involving the entire right angle of mandible, causing extensive bony resorption, and buccal, medial as well as inferior border cortical expansion with multiple perforations, in a young child is presented. It was treated successfully by enucleation and aggressive curettage followed by peripheral ostectomy preserving the continuity of the mandible. Two adjunctive measures were employed; first, chemical cauterization of the residual bony walls to prevent possible recurrence, for which this tumor is notorious, and second, placement of fresh autologous platelet-rich fibrin within the bony defect to hasten bone fill and reossification, thus obviating the need for a bone graft.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Management of central giant cell granulomas of the jaws: An unusual case report with critical appraisal of existing literature

Jeyaraj¹

2019

Ann Maxillofac Surg

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“…PAS and Grocott-Gomori methenamine special staining methods should be considered for definitive diagnosis. Individuals with pulmonary symptoms should be guided for chest radiographs [47].…”

Section: Diagnosismentioning

confidence: 99%

“…Disseminated blastomycosis affects the oral cavity and is characterized by ulcerated lesions that are indurated and have an elevated margin [50]. The induration and elevated borders confound the lesion as a carcinomatous area [47].…”

Section: Clinical Featurementioning

confidence: 99%

Fungal Infections of Oral Cavity: Diagnosis, Management, and Association with COVID-19

Santosh

Muddana

Bakki

2021

SN Compr. Clin. Med.

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The frequency of fungal infections is increasing due to immunodeficiency viruses and immunosuppressive drugs. The most common fungal infection of the oral cavity is candidiasis. The existence of Candida can be a part of normal commensal; hence, the isolation of Candida in the absence of clinical symptoms should exclude candidiasis. The pathogenicity of Candida is witnessed as opportunistic when immune status is compromised. Oral fungal infections are uncommon, but when identified, these infections are associated with greater discomfort and are sometimes destruction of tissues. Cytology and tissue biopsy are helpful in confirming the clinical diagnosis. The management of oral fungal infections must strategically focus on signs, symptoms, and culture reports. This article reviews information on diagnosis and therapeutic management of aspergillosis, cryptococcosis, histoplasmosis, blastomycosis, mucormycosis, and geotrichosis.

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Granulomatous Diseases Affecting Jaws

Cited by 2 publications

References 146 publications

Management of central giant cell granulomas of the jaws: An unusual case report with critical appraisal of existing literature

Management of central giant cell granulomas of the jaws: An unusual case report with critical appraisal of existing literature

Fungal Infections of Oral Cavity: Diagnosis, Management, and Association with COVID-19

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