Granulomatous Hepatitis Associated With Lyme Disease

Chavanet, P.; Pillon, D.; Lancon, J.P.; Waldner-Combernoux, A.; Maringe, E.; Portier, H.

doi:10.1016/s0140-6736(87)93009-1

Cited by 22 publications

(10 citation statements)

References 5 publications

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“…These include direct toxicity from the spirochete, systemic cytokine release, and, possibly, an immune-mediated event [2]. Although elevated aminotransferase has been seen, there has been only one case reported of granulomatous hepatitis from Lyme infection [3]. We describe here the first case of a patient with acute Lyme disease who was found to have necrotizing granulomatous hepatitis with eosinophilic infiltration of the liver.…”

Section: Introductionmentioning

confidence: 87%

Necrotizing Granulomatous Hepatitis as an Unusual Manifestation of Lyme Disease

et al. 2007

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Section: Introductionmentioning

confidence: 87%

Necrotizing Granulomatous Hepatitis as an Unusual Manifestation of Lyme Disease

et al. 2007

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“…There are 2 cases reported in the literature of granulomatous hepatitis presumably caused by Lyme’s Disease. [77,78]…”

Section: Bacteriamentioning

confidence: 99%

Infectious Diseases and the Liver

Talwani¹,

Gilliam²,

Howell³

2011

Clinics in Liver Disease

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“…10 Few of these pa-to Lyme disease in which other causes of acute hepatitients had confirmation of Lyme disease by serology tis were excluded. [3][4][5][6] In three of the four cases, improvement of liver test elevations occurred concomitantly with antibiotic treatment. [3][4][5] In the fourth case, the patient developed adult respiratory distress syndrome Borrelia recurrentis (over 30%).…”

Section: ) Only 5 (32%) Of the Initial 16 Patientsmentioning

confidence: 99%

“…[3][4][5][6] In three of the four cases, improvement of liver test elevations occurred concomitantly with antibiotic treatment. [3][4][5] In the fourth case, the patient developed adult respiratory distress syndrome Borrelia recurrentis (over 30%). 21 The relative lack of 5p0e$$0013 05-21-96 22:10:10 hepas WBS: Hepatology severity of the hepatic involvement in Lyme disease infiltrates, granulomatous changes, and fibrosis of the liver were demonstrated histologically in untreated most closely resembles the hepatic involvement by T. pallidum in secondary syphilis.…”

Section: ) Only 5 (32%) Of the Initial 16 Patientsmentioning

confidence: 99%

Liver Function in Early Lyme Disease

et al. 1996

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To evaluate the frequency, pattern, and severity of Lyme disease is a multisystemic infection caused by liver function test abnormalities in patients with Lyme the tick-borne spirochete, Borrelia burgdorferi. A great disease associated with erythema migrans (EM), 115 in-deal of attention has been paid to the dermatologic, dividuals with no other identifiable cause for liver func-musculoskeletal, cardiovascular, and neurological tion test abnormalities who presented with EM between manifestations of Lyme disease. 1,2 Acute hepatitis has July 1990 and September 1993 were prospectively evalu-been reported in the early stages of Lyme disease, 3-6 ated. For individuals with abnormal liver function tests, and hepatic enzyme elevations have been reported in common causes of hepatitis, including hepatitis A, B, 20% to 50% of patients with the characteristic rash of and C, were excluded. A local control group was used early Lyme disease, erythema migrans (EM). 2,7-10 Howfor comparison. Forty-six (40%) patients had at least one ever, there have been no prospective evaluations of heliver test abnormality, and 31 (27%) had more than 1 abnormality compared with 19 (19%) and 4 (4%) of con-patic dysfunction in treated patients for whom other trols, respectively (P õ .01 for each comparison). g-Gluta-major causes for liver disease were excluded. Moreover, myl transpeptidase (28%) and alanine transaminase there have been few prospective evaluations of liver (ALT) (27%) were the most frequently elevated liver function tests in a large group of patients in whom the function tests among Lyme disease patients. Anorexia, diagnosis of Lyme disease was confirmed by culture of nausea, or vomiting was reported by 30% of patients, but B. burgdorferi. To determine the frequency, severity, did not occur more frequently in patients with elevated and response to therapy of hepatitis associated with liver function tests compared with those with normal Lyme disease, we prospectively evaluated patients pre- Liver function test abnormalities are common in pa-The study population consisted of 124 consecutive untients with EM but were mild, most often not associated treated patients ¢16 years of age with a clinical diagnosis of with symptoms, and improved or resolved by 3 weeks EM who were enrolled in one of two ongoing treatment trials after the onset of antibiotic therapy in most patients. at the Lyme Disease Diagnostic Center of the Westchester

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Granulomatous Hepatitis Associated With Lyme Disease

Cited by 22 publications

References 5 publications

Necrotizing Granulomatous Hepatitis as an Unusual Manifestation of Lyme Disease

Necrotizing Granulomatous Hepatitis as an Unusual Manifestation of Lyme Disease

Infectious Diseases and the Liver

Liver Function in Early Lyme Disease

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