Infectious Diseases and the Liver

Talwani, Rohit; Gilliam, Bruce L.; Howell, Charles D.

doi:10.1016/j.cld.2010.09.002

Cited by 83 publications

(58 citation statements)

References 93 publications

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“…Immunological dysfunction along with bacterial translocation plays crucially in cirrhotic patients for catching infections [11] [12]. A recently described cirrhosis-associated immune dysfunction syndrome (CAIDS) is a multifactorial state of systemic immune dysfunction which decreases the ability to clear bacteria, cytokines, and endotoxins from circulation [13].…”

Section: Introductionmentioning

confidence: 99%

Infections in Cirrhotics: Types, Microbiological Spectrum and Risk Factors—5-Year Cohort Study

Naqvi¹,

Mahmood²,

Talib³

et al. 2014

OJGas

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Cirrhosis is an immunocompromised state that leads to various infections, with an estimated 30% mortality. Pakistan already has a high morbidity and mortality related to complications of cirrhosis. Where the data on infection among cirrhotics is scanty, this study aimed to determine the frequency, microbiological spectrum and various risk factors of infections in cirrhosis of liver. This is a prospective cohort study conducted at a tertiary care hospital. The microbiological spectrum and frequency of infections was determined in cirrhotics.

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Section: Introductionmentioning

confidence: 99%

Infections in Cirrhotics: Types, Microbiological Spectrum and Risk Factors—5-Year Cohort Study

Naqvi¹,

Mahmood²,

Talib³

et al. 2014

OJGas

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“…They both generally affect immunocompromised individuals as a result of de novo infection or reactivation of the latent infection. Illness commonly starts as mononucleosis syndrome with milder elevation of transaminases [11] unlike our patient where much higher levels of transaminases were recorded.…”

Section: Discussionmentioning

confidence: 58%

Fulminant Hepatic Failure Secondary to Herpes Hepatitis in a Patient With Myasthenia Crisis: An Elusive Diagnosis

et al. 2016

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Herpes hepatitis is a rare cause of fulminant hepatic failure contributing to less than 1% of all cases. It is most often seen in persons who are immunosuppressed and in pregnant women. The presentation is usually non-specific and rapidly progressive, thus making antemortem diagnosis of this condition rare. We present a patient who was on chronic immunosuppressive therapy for systemic lupus erythematosus and subsequently developed multi-organ failure with anicteric transaminitis as a result of disseminated herpes infection. The diagnosis was only made post-mortem. A confounding factor in this case was the fact that the patient underwent plasmapheresis, which skewed the interpretation of liver function tests in the setting of acute liver failure.

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“…Due to its role as a filter, the liver is exposed to many systemic infectious pathogens. These pathogens may directly or indirectly affect the liver depending on the characteristics of the pathogens [50]. Liver inflammation due to various etiologies can result in liver fibrosis, leading to cirrhosis and carcinogenesis [51].…”

Section: Discussionmentioning

confidence: 99%

Increased talin–vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections

Liu

Xiao

Zhang

et al. 2020

Laboratory Investigation

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Talin and vinculin, both actin-cytoskeleton-related proteins, have been documented to participate in establishing bacterial infections, respectively, as the adapter protein to mediate cytoskeleton-driven dynamics of the plasma membrane. However, little is known regarding the potential role of the talin-vinculin complex during spotted fever group rickettsial and Ebola virus infections, two dreadful infectious diseases in humans. Many functional properties of proteins are determined by their participation in protein-protein complexes, in a temporal and/or spatial manner. To resolve the limitation of application in using mouse primary antibodies on archival, multiple formalin-fixed mouse tissue samples, which were collected from experiments requiring high biocontainment, we developed a practical strategic proximity ligation assay (PLA) capable of employing one primary antibody raised in mouse to probe talin-vinculin spatial proximal complex in mouse tissue. We observed an increase of talin-vinculin spatial proximities in the livers of spotted fever Rickettsia australis or Ebola virusinfected mice when compared with mock mice. Furthermore, using EPAC1-knockout mice, we found that deletion of EPAC1 could suppress the formation of spatial proximal complex of talin-vinculin in rickettsial infections. In addition, we observed increased colocalization between spatial proximity of talin-vinculin and filamentous actin-specific phalloidin staining in single survival mouse from an ordinarily lethal dose of rickettsial or Ebola virus infection. These findings may help to delineate a fresh insight into the mechanisms underlying liver specific pathogenesis during infection with spotted fever rickettsia or Ebola virus in the mouse model.

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Infectious Diseases and the Liver

Cited by 83 publications

References 93 publications

Infections in Cirrhotics: Types, Microbiological Spectrum and Risk Factors—5-Year Cohort Study

Infections in Cirrhotics: Types, Microbiological Spectrum and Risk Factors—5-Year Cohort Study

Fulminant Hepatic Failure Secondary to Herpes Hepatitis in a Patient With Myasthenia Crisis: An Elusive Diagnosis

Increased talin–vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections

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