Granulomatous Interstitial Nephritis, Hypercalcemia and Rapidly Progressive Kidney Failure Secondary to Sarcoidosis with Exclusive Renal Involvement

Girón, Fernando Fernández; Mora, Francisco Fernández; Conde-García, Jaime; Sánchez, Manuel Benítez; Pérez, María José Merino; Muñoz, Sonia Cruz; Martínez, Joaquín González

doi:10.1159/000046660

Cited by 10 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 Most of these factors probably contributed to the renal failure in our patient. In contrast to the cases of renal sarcoidosis reported by Ohashi and colleagues 8 and Fernandez Giron et al, 9 where hypercalcaemia accompanied renal failure, the index case had normal calcium values at presentation. However, hypercalcaemia in the past probably contributed to the renal failure.…”

Section: Discussioncontrasting

confidence: 68%

Fatal renal failure as the first manifestation of sarcoidosis diagnosed on necropsy in a young man: a case report

Awasthi

Nada²,

Malhotra³

et al. 2004

J Clin Pathol

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 68%

Fatal renal failure as the first manifestation of sarcoidosis diagnosed on necropsy in a young man: a case report

Awasthi

Nada²,

Malhotra³

et al. 2004

J Clin Pathol

View full text Add to dashboard Cite

show abstract

“…4 The reported incidence of renal sarcoidosis varies (0.75 to 10%), in part due to varying definitions used in different studies. 5-8…”

Section: Commentmentioning

confidence: 99%

Renal Angiomyolipoma With Sarcoid Granulomas

2015

View full text Add to dashboard Cite

Angiomyolipoma is a mesenchymal neoplasm characterized by the coexpression of melanocytic and smooth muscle markers. Sarcoidosis is a multisystem disorder of unknown etiology, which presents with characteristic nonnecrotizing granulomas and rarely involves the kidney. The coexistence of renal sarcoidosis with renal neoplasms is exceedingly rare and was reported only with renal cell carcinoma. Renal sarcoidosis associated with a nonepithelial renal neoplasm, such as an angiomyolipoma has never been reported. We present the first reported case of sarcoid granulomas in a renal angiomyolipoma, including morphologic and immunohistochemical features.

show abstract

“…Seven patients were younger than 40 years, while 12 were older than 60 years. In contrast, sarcoidosis has been reported to affect females and young adults more frequently, with the incidence peaking between 20 and 39 years of age [2,20,21]. While these differences in age and male to female ratio characterize isolated granulomatous renal sarcoidosis, the precise cause for this variability remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

Isolated Renal Sarcoidosis Presenting with Granulomatous Interstitial Nephritis: A Case Report and Review of the Literature

Chikamatsu¹

2014

J Nephrol Ther

View full text Add to dashboard Cite

Background: Sarcoidosis is a multi-system disorder characterized by noncaseating epitheloid granuloma in multiple organs. However, granulomatous interstitial nephritis in the absence of extrarenal renal lesions is very rare. Case presentation: A 64-year-old male presented with a weight loss of 10 kg and an increase in serum creatinine from 1.1 to 4.8 mg/dl over a 1-year period. At admission, no proteinuria or hematuria was found, although serum creatinine was 5.1 mg/dl and was associated with slight increases in serum angiotensin converting enzyme and calcium levels. Renal biopsy revealed granulomatous interstitial nephritis with noncaseating epitheloid cells. The patient was diagnosed with sarcoidosis, although no extrarenal sarcoid lesion was found. Oral prednisolone was effective, with normalization of serum creatinine levels 2 weeks later. A review of the literature showed that isolated granulomatous renal sarcoidsosis preferentially affected elderly males, and their serum angiotensin converting enzyme levels were normal or mildly increased in many cases. Conclusions: This paper describes a rare case of isolated renal sarcoidosis with acute granulomatous interstitial nephritis. This case and a relevant review of the literature demonstrate that sarcoid granulomatous interstitial nephritis should be considered as one of differential diagnoses in elderly male patients with suspected tubulointerstitial nephritis irrespective of angiotensin converting enzyme levels.

show abstract

Granulomatous Interstitial Nephritis, Hypercalcemia and Rapidly Progressive Kidney Failure Secondary to Sarcoidosis with Exclusive Renal Involvement

Cited by 10 publications

References 15 publications

Fatal renal failure as the first manifestation of sarcoidosis diagnosed on necropsy in a young man: a case report

Fatal renal failure as the first manifestation of sarcoidosis diagnosed on necropsy in a young man: a case report

Renal Angiomyolipoma With Sarcoid Granulomas

Isolated Renal Sarcoidosis Presenting with Granulomatous Interstitial Nephritis: A Case Report and Review of the Literature

Contact Info

Product

Resources

About