Granulomatous Reaction to Hyaluronic Acid: A Case Series and Review of the Literature

Alsaad, Salman M. S.; Fabi, Sabrina G.; Goldman, Mitchel P.

doi:10.1111/j.1524-4725.2011.02214.x

Cited by 28 publications

(15 citation statements)

References 25 publications

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“…Early‐onset nodules, 1 week and 1 month after treatment, were considered to be injection related and resolved on their own. Two subjects injected periocularly and periorally and one subject injected periocularly developed large, erythematous, indurated late‐onset nodules (development ranging from 3 to 4 months after injection) at all sites of injection (Figure ) . Two subjects were amenable to biopsy of a representative nodule over the left lateral canthal area.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy and Safety of and Patient Satisfaction with Injectable Hyaluronic Acid with 0.3% Lidocaine Hydrochloride for the Treatment of Superficial Perioral Lines or Superficial Lateral Canthal Lines

Fabi

Champagne

Nettar

et al. 2013

Dermatologic Surgery

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Section: Resultsmentioning

confidence: 99%

“…A biopsy of the nodule demonstrated a granulomatous reaction in association with amorphous basophilic foreign material similar to that seen in patient 3. For a more‐detailed description of the AEs experienced in the study and a review of granulomatous reactions to HA, readers are directed to an article by Alsaad and colleagues …”

Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of and Patient Satisfaction with Injectable Hyaluronic Acid with 0.3% Lidocaine Hydrochloride for the Treatment of Superficial Perioral Lines or Superficial Lateral Canthal Lines

Fabi

Champagne

Nettar

et al. 2013

Dermatologic Surgery

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“…However, Alsaad et al . reported a high incidence (15%) of granulomatous nodules with a non‐animal stabilized HA product, possibly due to protein contaminant . Previously reported incidences of granulomatous reactions were in the range 0.02–2.8% .…”

Section: Nodule Formation and Granulomatous Reactionsmentioning

confidence: 96%

“…Biofilm‐related infections should be suspected in any erythematous, indurated areas that appear post treatment (Fig. ) . Cultures are usually but not always negative .…”

Section: Nodule Formation and Granulomatous Reactionsmentioning

confidence: 99%

Dermal fillers: pathophysiology, prevention and treatment of complications

Chiang

Pierone

Al‐Niaimi

2016

Acad Dermatol Venereol

142

144

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Dermal fillers are increasingly used for soft tissue augmentation of the face and hands. The widespread use of dermal fillers for rejuvenation has led to a rise in reports of associated complications. Although the majority of complications are mild and transient, serious and long-lasting complications have been observed. This article discusses the key complications including pigmentary changes, hypersensitivity reactions, infections, nodule formation, granulomatous reactions, vascular occlusion and migration of filler material. A thorough literature review was performed in addition to the combined extensive authors' (GP and FA) experience. Complications from fillers are increasingly being recognized and highlighted in the literature partly reflecting the growth in the market. This article provides a comprehensive overview of the filler complications with mechanisms of prevention and treatment per complication. A thorough understanding of the preventative and management strategies for the associated dermal filler complications will help the physician to prepare the patient well, and deal with complications that may arise effectively.

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“…Granulombildung nach Injektion von dermalen Fillermaterialien ist in der Literatur häufig beschrieben. Ursächlich können Verunreinigungen durch kleinste Proteinmengen sein [5]. Im Gegensatz hierzu wurden Fremdkörpergranu-lome nach Injektion von BoNT bislang nur in 3 Kasuistiken beschrieben [6][7][8] [7] berichten, dass ihre Patientin keine granulomatösen Hautveränderungen an vorhandenen Narben zeigte.…”

Section: Diskussionunclassified