Granulosa Cell Aromatase Activity in Women Undergoing IVF: A Comparison of Good and Poor Responders

Neal, Michael S.; Reade, Clare J.; Younglai, Edward V.; Holloway, Alison C.; Goodrow, Gwen J.

doi:10.1016/s1701-2163(16)32737-2

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…По не-которым данным, сниженный ответ на сти-муляцию у этих пациенток ассоциирован с уменьшением активности ароматазы клеток гранулезы [47]. По другим -ароматазная ак-тивность клеток гранулезы, полученных при трансвагинальной пункции фолликулов жен-щин с «бедным» и нормальным ответом на сти-муляцию суперовуляции в протоколах ЭКО, не различается [48].…”

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Aromatase P450 activity in the natural menstrual cycle and during controlled ovarian stimulation

Yakovlev

Павлович

2017

Z.akus.zen.bolezn

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The Aim of the study was to assess modern considerations about the role of aromatase P450 enzyme in female reproductive system and the effect of its activity on the protocols of in vitro fertilization (IVF). Materials: foreign and Russian literature data from 1978 to 2016. Methods:review and synthesis of publications has been performed. Conclusions: Ovarian aromatase is the key steroidogenesis enzyme of the female reproductive system. Its activity depends on many factors, both of intraovarian and extragonadal origin. The ovarian follicular response and oocyte quality in IVF may depend on aromatase activity.

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Aromatase P450 activity in the natural menstrual cycle and during controlled ovarian stimulation

Yakovlev

Павлович

2017

Z.akus.zen.bolezn

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Effects of in vitro maturation on gene expression in rhesus monkey oocytes

Lee

Latham

VandeVoort

2008

Physiological Genomics

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In vitro oocyte maturation (IVM) holds great promise as a tool for enhancing clinical treatment of infertility, enhancing availability of nonhuman primates for development of disease models, and facilitating endangered species preservation. However, IVM outcomes have remained significantly below the success rates obtained with in vivo matured (VVM) oocytes from humans and nonhuman primates. A cDNA array-based analysis is presented, comparing the transcriptomes of VVM oocytes with IVM oocytes. We observe a small set of just 59 mRNAs that are differentially expressed between the two cell types. These mRNAs are related to cellular homeostasis, cell-cell interactions including growth factor and hormone stimulation and cell adhesion, and other functions such as mRNA stability and translation. Additionally, we observe in IVM oocytes overexpression of PLAGL1 and MEST, two maternally imprinted genes, indicating a possible interruption or loss of correct epigenetic programming. These results indicate that, under certain IVM conditions, oocytes that are molecularly highly similar to VVM oocytes can be obtained; however, the interruption of normal oocyte-somatic cell interactions during the final hours of oocyte maturation may preclude the establishment of full developmental competence.

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Granulosa Cell Aromatase Activity in Women Undergoing IVF: A Comparison of Good and Poor Responders

Cited by 2 publications

References 18 publications

Aromatase P450 activity in the natural menstrual cycle and during controlled ovarian stimulation

Aromatase P450 activity in the natural menstrual cycle and during controlled ovarian stimulation

Effects of in vitro maturation on gene expression in rhesus monkey oocytes

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