Graphdiyne nanoplatforms for photothermal-ferroptosis combination therapy against glioblastoma

Zhao, Lingxiao; Gong, Zhiqiang; Zhang, Qi; He, Da-Long; Ge, Ri-Le; Meng, J.; Ren, Hang; Fan, Yingcai; Wang, Zhan-You

doi:10.1016/j.jconrel.2023.05.035

Cited by 22 publications

(8 citation statements)

References 68 publications

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“…116 Nanomaterials are also prone to biodegradation, bioavailability, and toxicity, raising questions about their long-term use. To circumvent these restrictions, different biomolecules, 117 polymers, 118 and inorganic or metal layers 119 are applied on the surface to alter the surface properties of the 2D sheet. In addition to altering the reactivity and solubility, coatings on 2D sheets can impact cell-material interactions and increase biocompatibility.…”

Section: Acs Biomaterialsmentioning

confidence: 99%

Potential Application Prospects of Biomolecule-Modified Two-Dimensional Chiral Nanomaterials in Biomedicine

Zhao,

Chen,

Cheng

et al. 2024

ACS Biomater. Sci. Eng.

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Chirality, one of the most fundamental properties of natural molecules, plays a significant role in biochemical reactions. Nanomaterials with chiral characteristics have superior properties, such as catalytic properties, optoelectronic properties, and photothermal properties, which have significant potential for specific applications in nanomedicine. Biomolecular modifications such as nucleic acids, peptides, proteins, and polysaccharides are sources of chirality for nanomaterials with great potential for application in addition to intrinsic chirality, artificial macromolecules, and metals. Two-dimensional (2D) nanomaterials, as opposed to other dimensions, due to proper surface area, extensive modification sites, drug loading potential, and simplicity of preparation, are prepared and utilized in diagnostic applications, drug delivery research, and tumor therapy. Current advanced studies on 2D chiral nanomaterials for biomedicine are focused on novel chiral development, structural control, and materials sustainability applications. However, despite the advances in biomedical research, chiral 2D nanomaterials still confront challenges such as the difficulty of synthesis, quality control, batch preparation, chiral stability, and chiral recognition and selectivity. This review aims to provide a comprehensive overview of the origins, synthesis, applications, and challenges of 2D chiral nanomaterials with biomolecules as cargo and chiral modifications and highlight their potential roles in biomedicine.

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Section: Acs Biomaterialsmentioning

confidence: 99%

Potential Application Prospects of Biomolecule-Modified Two-Dimensional Chiral Nanomaterials in Biomedicine

Zhao,

Chen,

Cheng

et al. 2024

ACS Biomater. Sci. Eng.

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“…Ling-Xiao Zhao et al designed a GFR nanoplatform, GDY-FIN56-RAP (GFR), with the potential for photothermal therapy (PTT) for the treatment of GBM by encapsulating a RAP-polymer and an ferroptosis inducer, FIN56, on graphdiyne (GDY). 240 GFR combined with 808 nm near-infrared radiation significantly triggered GPX4 down-regulation-mediated ferroptosis of GBM cells, which inhibited GBM growth and prolonged the lifespan of the GBM in situ xenograft mouse model. Near-infrared radiation facilitated the release of FIN56 from the GFR and directly induced GBM cell death through temperature elevation—directly induced GBM cell death.…”

Section: Ferroptosis Inducersmentioning

confidence: 99%

“…The GFR nanoplatforms can penetrate the blood-brain barrier and induce an acidic environment-induced in situ release of FIN56. 240 …”

Section: Ferroptosis Inducersmentioning

confidence: 99%

“…The GFR nanoplatforms can penetrate the blood-brain barrier and induce an acidic environment-induced in situ release of FIN56. 240 Cheng et al successfully developed an injectable hydrogel, Gel@WA-cRGD, that combines the induction of ferroptosis and immunomodulation effects. The hydrogel was created through Ca 2+ -mediated cross-linking of natural sodium alginate, incorporating crgd-modified redox-responsive Withaferin prodrugs (WA-cRGD) and programmed cell death ligand 1 antibody (aPD-L1) for targeted tumor treatment.…”

Section: Dovepressmentioning

confidence: 99%

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Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Luo,

Bai,

Zhang

et al. 2024

DDDT

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“…During the utilization of 808 nm rays, these GFR-mediated effects were further improved. Finally, the investigators concluded that the GFR could prove to be a suitable nanomedicine for the treatment of cancer and GFR clubbed with PTT could prove to be a promising approach against GBM [ 288 ].…”

Section: Neurological Diseases Associated With Signaling Pathways Of ...mentioning

confidence: 99%

Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis

Yadav,

Choudhary,

Gacem

et al. 2023

Redox Report

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Ferroptosis is an emerging and novel type of iron-dependent programmed cell death which is mainly caused by the excessive deposition of free intracellular iron in the brain cells. This deposited free iron exerts a ferroptosis pathway, resulting in lipid peroxidation (LiPr). There are mainly three ferroptosis pathways viz. iron metabolism-mediated cysteine/glutamate, and LiPr-mediated. Iron is required by the brain as a redox metal for several physiological activities. Due to the iron homeostasis balance disruption, the brain gets adversely affected which further causes neurodegenerative diseases (NDDs) like Parkinson's and Alzheimer's disease, strokes, and brain tumors like glioblastoma (GBS), and glioma. Nanotechnology has played an important role in the prevention and treatment of these NDDs. A synergistic effect of nanomaterials and ferroptosis could prove to be an effective and efficient approach in the field of nanomedicine. In the current review, the authors have highlighted all the latest research in the field of ferroptosis, specifically emphasizing on the role of major molecular key players and various mechanisms involved in the ferroptosis pathway. Moreover, here the authors have also addressed the correlation of ferroptosis with the pathophysiology of NDDs and theragnostic effect of ferroptosis and nanomaterials for the prevention and treatment of NDDs.

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Graphdiyne nanoplatforms for photothermal-ferroptosis combination therapy against glioblastoma

Cited by 22 publications

References 68 publications

Potential Application Prospects of Biomolecule-Modified Two-Dimensional Chiral Nanomaterials in Biomedicine

Potential Application Prospects of Biomolecule-Modified Two-Dimensional Chiral Nanomaterials in Biomedicine

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis

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