Graphene-based materials for tissue engineering

Shin, Su Ryon; Li, Yi Chen; Jang, Hae Lin; Khoshakhlagh, Parastoo; Akbari, Mohsen; Nasajpour, Amir; Zhang, Yu Shrike; Tamayol, Ali; Khademhosseini, Ali

doi:10.1016/j.addr.2016.03.007

Cited by 581 publications

(441 citation statements)

References 186 publications

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“…These results indicating that the hydrogel, especially those with rGO were beneficial to ECM remodeling and tissue regeneration. Graphene with high specific surface area exhibits favorable interaction pattern with tissues, cells and even biomolecules, thus improving the rGO incorporated hydrogel's bioactivity to enhance the wound healing process . In addition, the unique structure of graphene makes it easy for electrons to escape from graphene into cells under the action of the cell membrane .…”

Section: Resultsmentioning

confidence: 99%

“…Our previous researches have also proved the promoting effect of biomaterials with conductivity properties in wound healing process . Graphene is a promising candidate material for its excellent electrical conductivity, biocompatibility, high surface area, and mechanical strength . Incorporation of graphene into HA‐DA hydrogel can result in conductive HA‐DA hydrogel dressing, which may favor to enhance the wound healing process.…”

Section: Introductionmentioning

confidence: 99%

“…Incorporation of graphene into HA‐DA hydrogel can result in conductive HA‐DA hydrogel dressing, which may favor to enhance the wound healing process. The high specific surface area also exhibits peculiar interactional pattern with biomolecules, cells, and even human tissues to improve the hydrogel's bioactivity . However, the disadvantage of poor dispersity seriously limits graphene's application .…”

Section: Introductionmentioning

confidence: 99%

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Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full‐Thickness Skin Regeneration During Wound Healing

Liang

Zhao

et al. 2019

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701

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Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full‐thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid‐graft‐dopamine and reduced graphene oxide (rGO) using a H2O2/HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. The polydopamine endowed antioxidant activity, tissue adhesiveness and hemostatic ability, self‐healing ability, conductivity, and NIR irradiation enhanced in vivo antibacterial behavior of the hydrogels are investigated. Moreover, drug release and zone of inhibition tests confirm sustained drug release capacity of the hydrogels. Furthermore, the hydrogel dressings significantly enhance vascularization by upregulating growth factor expression of CD31 and improve the granulation tissue thickness and collagen deposition, all of which promote wound closure and contribute to a better therapeutic effect than the commercial Tegaderm films group in a mouse full‐thickness wounds model. In summary, these adhesive hemostatic antioxidative conductive hydrogels with sustained drug release property to promote complete skin regeneration are an excellent wound dressing for full‐thickness skin repair.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full‐Thickness Skin Regeneration During Wound Healing

Liang

Zhao

et al. 2019

Small

1,046

701

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“…Graphene oxide (GO) is a resistant two-dimensional structural molecule, with the thickness of a carbon atom and high strength, and presents high stability and properties of a low annular tension aromatic polycycle (Kelly & Billups, 2013). Additionally, GO nanosheets may improve the chemical function and mechanical strength of the natural hydrogels (Shin et al, 2016;Valencia et al, 2018). Additionally, GO nanosheets may improve the chemical function and mechanical strength of the natural hydrogels (Shin et al, 2016;Valencia et al, 2018).…”

Section: New Technologiesmentioning

confidence: 99%

Strategies in cell‐free tissue‐engineered vascular grafts

Yuan

Chen

Liu

et al. 2019

J Biomedical Materials Res

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Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality in the world, among which coronary artery diseases (CAD) are the most common type of CVD. Coronary artery bypass grafting (CABG) using autologous vein and artery grafts is the typical surgical intervention for CAD patients. However, for patients whose autologous grafts are not available, there are no appropriate substitutes for vascular grafts. Investigation of tissue-engineered vascular graft (TEVG) has persisted over decades with significant advancement, utilizing different types of biomaterials.In the past two decades, a great number of studies based on cell-seeding strategies were reported. However, limitations of cell-based strategies made clinical application difficult. With the understanding of stem cells and tissue remodeling process, strategies without cell-seeding emerged as potential methods to achieve in situ regeneration.A cell-free graft may recruit host cells and guide their participation in vascular remodeling. The grafts modified by bio-active molecules showed good results in promoting in situ regeneration and exhibited potential to make the vascular grafts off-the-shelf.In this review, the strategies for cell-free TEVG manufacturing were discussed, including the materials for fabricating TEVGs, the methods of functionalization to promote in situ regeneration, the challenges researchers faced in TEVG investigation, and finally the prospects in TEVG design.

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“…The stress has been made on those materials that have been approved for therapeutic purposes by the FDA. Carbon based nanomaterials for biomedical and tissue engineering applications have been discussed elsewhere [11]. In the first section, nanomaterials of inorganic origin including gold, magnetic, and silica-based materials for drug delivery are discussed.…”

Section: Introductionmentioning

confidence: 99%

Evolution and clinical translation of drug delivery nanomaterials

et al. 2017

Self Cite

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With the advent of technology, the role of nanomaterials in medicine has grown exponentially in the last few decades. The main advantage of such materials has been exploited in drug delivery applications, due to their effective targeting that in turn reduces systemic toxicity compared to the conventional routes of drug administration. Even though these materials offer broad flexibility based on targeting tissue, disease, and drug payload, the demand for more effective yet highly biocompatible nanomaterial-based drugs is increasing. While therapeutically improved and safe materials have been introduced in nanomedicine platforms, issues related to their degradation rates and bio-distribution still exist, thus making their successful translation for human use very challenging. Researchers are constantly improving upon novel nanomaterials that are safer and more effective not only as therapeutic agents but as diagnostic tools as well, making the research in the field of nanomedicine ever more fascinating. In this review stress has been made on the evolution of nanomaterials that have been approved for clinical applications by the United States Food and Drug Administration Agency (FDA).

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Graphene-based materials for tissue engineering

Cited by 581 publications

References 186 publications

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full‐Thickness Skin Regeneration During Wound Healing

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full‐Thickness Skin Regeneration During Wound Healing

Strategies in cell‐free tissue‐engineered vascular grafts

Evolution and clinical translation of drug delivery nanomaterials

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