Graphene-based nanomaterials for drug delivery and tissue engineering

Goenka, Sumit; Sant, Vinayak; Sant, Shilpa

doi:10.1016/j.jconrel.2013.10.017

Cited by 1,168 publications

(724 citation statements)

References 161 publications

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“…Approaches include its functionalization with cationic polymer, for example PEI [24]. It is used as a non-viral gene vector as it can strongly interact with the negatively charged phosphate ions of DNA and RNA [24].…”

Section: Small Molecule Drug Deliverymentioning

confidence: 99%

“…It is used as a non-viral gene vector as it can strongly interact with the negatively charged phosphate ions of DNA and RNA [24]. It makes transfection easy and efficient, improves cell selectivity and reduces cell toxicity.…”

Section: Small Molecule Drug Deliverymentioning

confidence: 99%

“…Graphene has specific catalytic, mechanical, electronic, thermal, biological and optical properties [7,[20][21][22], which allow it to be used for biomolecule recognition, bioassays, molecular medicine and small molecular drug delivery. The biocompatibility and quick functionalization make graphene an assuring platform in tissue engineering [23], molecular drug delivery [24], cancer treatment [25], biosensing [26], and bioimaging [27]. Graphene-based materials are used in the field of bone repair or organ regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Graphene and graphene oxide as nanomaterials for medicine and biology application

et al. 2018

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Graphene-and graphene oxide-based nanomaterials have gained broad interests in research because of their unique physiochemical properties. The 2D allotropic structure allows it to be used in various biological fields. The biomedical applications of graphene and its composite include its use in gene and small molecular drug delivery. It is further used for biofunctionalization of protein, in anticancer therapy, as an antimicrobial agent for bone and teeth implantation. The biocompatibility of the newly synthesized nanomaterials allows its substantial use in medicine and biology. The current review summarizes the chemical structure and biological application of graphene in various fields.

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Section: Small Molecule Drug Deliverymentioning

confidence: 99%

Section: Small Molecule Drug Deliverymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Graphene and graphene oxide as nanomaterials for medicine and biology application

et al. 2018

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“…[12,13] Graphene (Gr) is a relatively new material that has seen applications in many branches of materials science, from electronic and thermoregulatory devices, [14][15][16] to biomedical applications. [17,18] As a 2D carbon-atom monolayer, Gr has high mechanical strength and excellent thermal and electrical conductivity, [19,20] which makes it strong candidate for improvement of many properties of compo-site materials. Indeed, graphene has been reported to improve many physico-mechanical properties of polymer composites, e.g.…”

Section: Introductionmentioning

confidence: 99%

Graphene Based Composite Hydrogel for Biomedical Applications

Nešović¹,

Abudabbus²,

Rhee³

et al. 2017

Croat. Chem. Acta

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In this work, composite hydrogel consisting of poly(vinyl alcohol), graphene and silver nanoparticles, (Ag/PVA/Gr), was prepared by the immobilization of silver nanoparticles (AgNPs) in PVA/Gr hydrogel matrix in two steps. The first step was cross linking of the PVA/Gr colloid solution by the freezing/thawing method, while in the second step, in situ electrochemical method was used to incorporate AgNPs inside the PVA/Gr hydrogel matrix. We used UV-vis spectroscopy, cyclic voltammetry, Raman spectroscopy, DSC analysis, as well as test of cytotoxicity and antibacterial activity, to characterize obtained Ag/PVA/Gr hydrogel. It was shown that graphene-based composite hydrogel with incorporated AgNPs is non toxic biomaterial with antibacterial activity, with a potential for use in biomedical purposes.

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“…The cationic polyethylenimine (PEI) polymer that has a strong electrostatic interaction with the negatively charged phosphate of RNA or DNA can be easily decorated onto the surface of graphene in gene therapy, which enables it to treat genetic disorders like cystic fibrosis, Parkinson's disease, and cancer whilst significantly lowering the cytotoxicity of PEI [6]. Furthermore, the ability to adsorb single-stranded DNA onto graphene sheets, the capacity to quench electron donors, and the function of transportation in living cells and in vivo systems has made graphene even more promising [21]. However, in order to apply these outstanding capabilities of graphene to the biomedical field, numerous unsolved issues such as non-homogenous size, undesirable toxicity, and uncertainty of distribution data exists and hampers the clinical application.…”

mentioning

confidence: 99%

Radio-graphene in Theranostic Perspectives

Hwang

2016

Nucl Med Mol Imaging

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Owing to its unique physicochemical properties such as high surface area, notable biocompatibility, robust mechanical strength, high thermal conductivity, and ease of functionalization, 2D-layered graphene has received tremendous attention as a futuristic nanomaterial and its-associated research has been rapidly evolving in a variety of fields. With the remarkable advances of graphene especially in the biomedical realm, in vivo evaluation techniques to examine in vivo behavior of graphene are largely demanded under the hope of clinical translation. Many different types of drugs such as the antisense oligomer and chemotherapeutics require optimal delivery conveyor and graphene is now recognized as a suitable candidate due to its simple and high drug loading property. Termed as 'radio-graphene', radioisotope-labeled graphene approach was recently harnessed in the realm of biomedicine including cancer diagnosis and therapy, contributing to the acquisition of in vivo information for targeted drug delivery. In this review, we highlight current examples for bioapplication of radiolabeled graphene with brief perspectives on future strategies in its extensive bio-or clinical applications.

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Graphene-based nanomaterials for drug delivery and tissue engineering

Cited by 1,168 publications

References 161 publications

Graphene and graphene oxide as nanomaterials for medicine and biology application

Graphene and graphene oxide as nanomaterials for medicine and biology application

Graphene Based Composite Hydrogel for Biomedical Applications

Radio-graphene in Theranostic Perspectives

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