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iii Polymeric elastomers like Poly (1,3-diamino-2-hydroxypropane-co-polyol sebacate) (APS) have gained importance in soft tissue engineering applications due to their tunable mechanical properties and biodegradability. The fabrication of extracellular matrix (ECM)-mimetic nanofibrous scaffolds using APS is however limited due to its poor solubility in commonly used solvents, low viscosity and high temperatures required for thermal curing. In this study, we have NANOFIBROUS COMPOSITE SCAFFOLDS OF POLY(ESTER AMIDES) WITH TUNABLE PHYSICOCHEMICAL AND DEGRADATION PROPERTIESFNU Shilpaa Mukundan, B.Tech.University of Pittsburgh, 2015 iv scaffolds. Biocompatibility studies using C2C12 mouse myoblast cells showed enhanced cell spreading on APS containing scaffolds after 6h as compared to PCL-only scaffolds. Thus, the present study demonstrates successful development of APS-based thermoset elastomeric nanofibrous scaffolds by blending with semicrystalline PCL polymer for the first time. Tunable physicochemical, mechanical and degradation properties of these composite APS-PCL scaffolds will be further exploited for skeletal muscle tissue engineering applications.

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