Graphene Family Nanomaterials for Stem Cell Neurogenic Differentiation and Peripheral Nerve Regeneration

Hui, Yuxuan; Yan, Zhiwen; Yang, Hao; Xu, Xingxing; Yuan, Weien; Qian, Yun

doi:10.1021/acsabm.2c00663

Cited by 19 publications

(15 citation statements)

References 158 publications

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“…The high mechanical strength and flexibility of GFNs make them ideal for microneedles that require precise and controlled insertion into the skin. 123 …”

Section: Biomedicine Application Of Gfnsmentioning

confidence: 99%

Potential Biomedical Limitations of Graphene Nanomaterials

Ban¹,

Hou²,

Shen³

et al. 2023

IJN

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Graphene-family nanomaterials (GFNs) possess mechanical stiffness, optical properties, and biocompatibility making them promising materials for biomedical applications. However, to realize the potential of graphene in biomedicine, it must overcome several challenges that arise when it enters the body’s circulatory system. Current research focuses on the development of tumor-targeting devices using graphene, but GFNs accumulated in different tissues and cells through different pathways, which can cause toxic reactions leading to cell apoptosis and body dysfunction when the accumulated amount exceeds a certain limit. In addition, as a foreign substance, graphene can induce complex inflammatory reactions with immune cells and inflammatory factors, potentially enhancing or impairing the body’s immune function. This review discusses the biomedical applications of graphene, the effects of graphene materials on human immune function, and the biotoxicity of graphene materials.

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“…The high mechanical strength and flexibility of GFNs make them ideal for microneedles that require precise and controlled insertion into the skin. 123 …”

Section: Biomedicine Application Of Gfnsmentioning

confidence: 99%

Potential Biomedical Limitations of Graphene Nanomaterials

Ban¹,

Hou²,

Shen³

et al. 2023

IJN

View full text Add to dashboard Cite

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“…reported GO to possess an inhibitory effect on AChE activity [25] . Recent literature also reports the advantageous effects of G/GO family of nanomaterials toward the enhancement of neural tissue engineering through the fabrication of nerve scaffolds [26] . Correspondingly, the superior electrical conductivity of these nanomaterials depicts their effectiveness as electrodes in neuronal migration pathways.…”

Section: Introductionmentioning

confidence: 99%

“…[25] Recent literature also reports the advantageous effects of G/GO family of nanomaterials toward the enhancement of neural tissue engineering through the fabrication of nerve scaffolds. [26] Correspondingly, the superior electrical conductivity of these nanomaterials depicts their effectiveness as electrodes in neuronal migration pathways. Another study by Qian et al reported the augmented efficiency of GO/polycaprolactone in axonal regeneration.…”

Section: Introductionmentioning

confidence: 99%

Molecular Insights on the Modulated Acetylcholinesterase Inhibition Activity of Tacrine Adsorbed on Biocompatible Graphene Oxide

et al. 2023

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Graphene oxide (GO) based nano‐formulation has gained much attention because of its carbonaceous composition with biologically benign properties. In this study, the interactions of GO with tacrine (TAC), an FDA approved Alzheimer's disease (AD) drug, are explored using various analytical tools and theoretical modeling techniques. Furthermore, the modulatory effect of these nano‐conjugates toward the in‐vitro catalytic activity of the neurodegenerative enzyme acetylcholinesterase (AChE) is also quantified. The maximal rate for enzyme inhibition in presence of the nanoconjugate decreases up to an extent of 16 and 34 % in comparison with TAC and GO, respectively. Interestingly, these results are in sharp contrast to the increased AChE activity on adsorption into spherical gold and silver nanoparticles. The current findings demonstrate the synergistic use of TAC−GO hybrid material with augmented AChE inhibition efficacy towards the treatment of Alzheimer's disease (AD). Additionally, GO presents a sustainable alternative for biomedical applications to inorganic equivalents.

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“…[25][26][27] In recent years, the emerging conductive material graphene and its derivatives have stood out in neural tissue engineering due to their outstanding physicochemical properties, including superior electrical and thermal conductivity, a large specific surface area, and excellent mechanical properties. 28,29 Among them, graphene-based materials have been shown to improve the adhesion, proliferation, and differentiation of various cells, including neural stem cells, as well as the germination and growth of neural synapses. 30,31 However, graphene is hydrophobic and has some cytotoxicity.…”

Section: Introductionmentioning

confidence: 99%