Graphene-incorporated nanofibrous hybrid membrane with enhanced properties

Shin, Ueon Sang; Park, Jeong-Soon; Oh, Jun-Sung; Lee, Eunjung

doi:10.1007/s13233-017-5151-4

Cited by 4 publications

(7 citation statements)

References 16 publications

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“…8 Different strategies can be adopted to overcome these drawbacks. The development of new materials based on polymeric composites 5,9 or graphene/graphene oxide composites 10,11 are promising approaches, leading to the proliferation and osteogenic differentiation of osteoblastic cells. An alternative strategy is the incorporation of osteostimulatory compounds.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of simvastatin in PLLA membranes for guided bone regeneration: effect of thermal treatment on simvastatin release

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Incorporation of simvastatin in PLLA membranes for guided bone regeneration: effect of thermal treatment on simvastatin release

et al. 2018

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“…77 experiments were assessed in the manuscripts reviewed. Calcium was associated with graphene in 30 experiments, 37,38,40,41,46,47,58–63,66,77,78,81–83,85,88,89,94–98,102,106,107,110 with 35 experiments presenting the association of graphene with Natural Polymers, 35,39,42–45,47,50–52,56,58,59,62–64,66–71,74,77,81,83,84,86–90,93,100,102,109 and 30 experiments presenting the association of Synthetic Polymers 31,37,48,49,53,54,57,61,65,68,72,73,75,76,79,…”

Section: Resultsmentioning

confidence: 98%

“…109,110 All animal models successfully compared osteogenesis capability, but the size of the defect was not adequately described to make a pattern for later comparison. However, the sites of the defect could be listed as a cranial defect in 49 experiments, 31,35,39–44,47–50,52,54–56,59–63,65,67,69,71–75,77–81,83,84,86–91,93,94,96,98,100,109,110 limb defect in 25 experiments, 36–38,45,46,51,53,58,64,66,68,70,76,82,85,92,95,97,99,101–103,105–107 or jaw defect in four experiments. 39,57,104,108 These findings may reflect the exposition to functional charges or not during bone repair.…”

Section: Resultsmentioning

confidence: 99%

“…77 experiments were assessed in the manuscripts reviewed. Calcium was associated with graphene in 30 experiments, 37,38,40,41,46,47,[58][59][60][61][62][63]66,77,78,[81][82][83]85,88,89,[94][95][96][97][98]102,106,107,110 with 35 experiments presenting the association of graphene with Natural Polymers, 35,39,[42][43][44][45]47,[50][51][52]56,58,59,[62][63][64][66][67][68][69][70]…”

Section: Type Of Associated Scaffoldsmentioning

confidence: 99%

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A scoping review of graphene-based biomaterials for in vivo bone tissue engineering

Achôa

Mattos²,

Clements

et al. 2023

J Biomater Appl

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The growing demand for more efficient materials for medical applications brought together two previously distinct fields: medicine and engineering. Regenerative medicine has evolved with the engineering contributions to improve materials and devices for medical use. In this regard, graphene is one of the most promising materials for bone tissue engineering and its potential for bone repair has been studied by several research groups. The aim of this study is to conduct a scoping review including articles published in the last 12 years (from 2010 to 2022) that have used graphene and its derivatives (graphene oxide and reduced graphene) in preclinical studies for bone tissue regeneration, searching in PubMed/MEDLINE, Embase, Web of Science, Cochrane Central, and clinicaltrials.gov (to confirm no study has started with clinical trial). Boolean searches were performed using the defined key words “bone” and “graphene”, and manuscript abstracts were uploaded to Rayyan, a web-tool for systematic and scoping reviews. This scoping review was conducted based on Joanna Briggs Institute Manual for Scoping Reviews and the report follows the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses – Extension for Scoping Reviews (PRISMA- ScR) statement. After the search protocol and application of the inclusion criteria, 77 studies were selected and evaluated by five blinded researchers. Most of the selected studies used composite materials associated with graphene and its derivatives to natural and synthetic polymers, bioglass, and others. Although a variety of graphene materials were analyzed in these studies, they all concluded that graphene, its derivatives, and its composites improve bone repair processes by increasing osteoconductivity, osteoinductivity, new bone formation, and angiogenesis. Thus, this systematic review opens up new opportunities for the development of novel strategies for bone tissue engineering with graphene.

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“…The cytotoxicity of MXene was evaluated in human mesenchymal stem cells (hMSCs, A15652, Thermo Fischer, Waltham, MA, USA) treated with MXene at concentrations of 0–100 μg/mL and cultured for up to 7 days. Cell proliferation was assessed using the MTS kit (G3580, Promega, Madison, WI, USA) [ 22 ], and cell morphology was observed after culture for 1 day using confocal laser scanning microscopy (CLSM; Zeiss).…”

Section: Methodsmentioning

confidence: 99%

Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells

Jang

Lee

2021

Materials

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MXenes with a two-dimensional (2D) structure have attracted attention as potential biomedical materials. In this study, Ti3C2 MXene particles with 2D-lamellar structures were intercalated and their potential as a biomaterial was evaluated using human mesenchymal stem cells. Intercalated MXene was characterized in terms of microstructure, phase composition, and size. Cell proliferation experiments with MXene particles confirmed that concentrations >50 μg/mL were cytotoxic, while concentrations <20 μg/mL promoted osteogenic differentiation. Moreover, MXene effectively facilitated the early and late osteogenic gene expression.

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Graphene-incorporated nanofibrous hybrid membrane with enhanced properties

Cited by 4 publications

References 16 publications

Incorporation of simvastatin in PLLA membranes for guided bone regeneration: effect of thermal treatment on simvastatin release

Incorporation of simvastatin in PLLA membranes for guided bone regeneration: effect of thermal treatment on simvastatin release

A scoping review of graphene-based biomaterials for in vivo bone tissue engineering

Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells

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