Graphene-induced apoptosis in lung epithelial cells through EGFR

Bangalore, Preeti; Chen, Eric; Lu, David; Chiu, Meng-Hsuen; Sinclair, Andrew; Gehring, Matthew; Cangco, John P.; Garcia, Santiago G.; Chin, Wei‐Chun

doi:10.1007/s11051-017-3957-9

Cited by 17 publications

(15 citation statements)

References 54 publications

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“…We have conducted numerous toxicity experiments on trachea airway cells with a variety of NPs in our previous study [26, 27], therefore this cell line was chosen for this biological study. In order to assess the overall toxicity of LSM on trachea cells, the colorimetric CCK8 cell viability assay was performed [25, 27]. As seen in Fig.…”

Section: Resultsmentioning

confidence: 99%

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Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells

et al. 2019

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Research on the toxicity of nanoparticles has developed over recent years due to their increasing prevalence in common everyday materials. Various nanoparticles have been reported to promote and induce mucus secretion, which could potentially lead to airway damages and respiratory complications. Lanthanum strontium manganite (LSM) is a nanoparticle widely used in solar oxidized fuel cells (SOFCs) due to its high electrical conductivity, high electrochemical activity for O2 reduction reaction, high thermal stability and compatibility of SOFC electrolytes, and most importantly, its microstructural stability and long-term performance. Very few studies have been conducted on LMS’s toxicity, thus its effect on airway cells was investigated in this study. After treating trachea cells with increasing concentrations of LSM ranging up to 500 μg/ml, we found that it has a moderate effect on cell viability, ROS production, cytochrome C, and caspase 3 expression. Despite its minimal impact on stated apoptosis-inducing characteristics, LSM illustrated an inhibiting effect on mucus secretion. We obtained a decreasing trend in mucus secretion with an increased concentration of the LSM treatment. Overall, LSM’s advancement in SOFCs necessitated a toxicity study, and although it does not show a significant toxicity to trachea cells, LSM reduces mucus secretion, and can potentially interfere with airway clearance.

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Section: Resultsmentioning

confidence: 99%

“…We then analyzed the reactive oxygen species (ROS) production and mitochondria damage along with the mucus secretion response with fluorescent microscopy [24]. The level of apoptosis progression with or without LSM nanoparticles was examined with cytochrome C and caspase 3 assays [25].…”

Section: Introductionmentioning

confidence: 99%

Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells

et al. 2019

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“…Photocolorimetric determination of cytotoxicity was assessed using CCK-8 dye (Dojindo Laboratories, Tokyo, Japan)(Chen et al, 2008; Tsai et al, 2017). CCK-8, being non-radioactive, offers a colorimetric determination of the percentage of viable cells subjected to varying NP concentrations.…”

Section: Methodsmentioning

confidence: 99%

CeO2 nanoparticles attenuate airway mucus secretion induced by TiO2 nanoparticles

Duran-Robles

Goshia

Mesina

et al. 2018

Science of The Total Environment

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Nanotoxicity studies associated with various nanoparticles (NPs) have attracted intense research interest due to the broader applications of nanoparticles in our daily lives. The exposure of nanoparticles can lead to hypersecretion and accumulation of airway mucus which are closely associated with many respiratory diseases. Titanium dioxide (TiO), one of the PM10 components, is a major NP that is widely utilized in many commercial products. Our previous study established the connection between induced airway mucus secretion and TiO NPs. However, the countermeasure to reduce the harmful effects of TiO NPs, especially airway mucus secretion, remains unexplored. One of the potential candidates to reduce airway mucus secretion is cerium oxide (CeO) NPs. It has been reported that CeO NPs can protect cells by diminishing ROS and inflammatory responses. Herein, our study shows that CeO NPs are able to reduce cytosolic Ca changes and mitochondrial damage caused by TiO NPs. Our results provide the evidence that hypersecretion of mucus and apoptosis progression induced by TiO NPs can be attenuated by CeO NPs. This study highlights the potential capacity of CeO NPs as a supplementary material for TiO NPs applications in the future.

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“… N.A. respiratory diseases BEAS-2B cells [ 205 ] GO Polymer pH anticancer Hela and L929 cells [ 206 ] …”

Section: The Field Of 2d Materials Sddss Therapymentioning

confidence: 99%

“…By activating IP 3 pathway, graphene induced an increase in Ca 2+ transportation. In fact, cystolic Ca 2+ increase stimulates Ca 2+ mediated apoptosis with increased Ca 2+ transportation [ 205 ].…”

Section: Advantages and Disadvantages Of Two-dimensional Materials Inmentioning

confidence: 99%

Recent advances of two-dimensional materials in smart drug delivery nano-systems

Zhang

Fan

Chen

et al. 2020

Bioactive Materials

145

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Smart drug delivery nano-systems show significant changes in their physical or chemical properties in response to slight change in environmental physical and/or chemical signals, and further releasing drugs adjusted to the progression of the disease at the right target and rate intelligently. Two-dimensional materials possess dramatic status extend all over various scientific and technological disciplines by reason of their exceptional unique properties in application of smart drug delivery nano-systems. In this review, we summarized current progress to highlight various kinds of two-dimensional materials drug carriers which are widely explored in smart drug delivery systems as well as classification of stimuli responsive two-dimensional materials and the advantages and disadvantages of their applications. Consequently, we anticipate that this review might inspire the development of new two-dimensional materials with smart drug delivery systems, and deepen researchers’ understanding of smart nano-carries based on two-dimensional materials.

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Graphene-induced apoptosis in lung epithelial cells through EGFR

Cited by 17 publications

References 54 publications

Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells

Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells

CeO2 nanoparticles attenuate airway mucus secretion induced by TiO2 nanoparticles

Recent advances of two-dimensional materials in smart drug delivery nano-systems

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