Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy

Dou, Wei; Xu, Fugui; Xu, Chen; Gao, Jie; Ru, Hong Bo; Luan, Xiangfeng; Zhang, Jiacheng; Zhu, Ling; Sedgwick, Adam; Chen, Guo Rong; Zang, Yi; James, Tony D.; Tian, He; Li, Jia; Mai, Yiyong; He, Xiao

doi:10.1039/d1sc02154k

Cited by 17 publications

(6 citation statements)

References 55 publications

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“…TEM was used for the visualization of the morphological changes of Pseudomonas aeruginosa (ATCC 27853, 10 6 CFU ml −1 ) in the presence of the AgNP/ChS/GNR nanocomposite; while, AgNP, ChS, AgNP/ChS and GNR were used as controls ( Figure 2 ). Considering the outstanding photothermal property of GNR ( Huang et al, 2018 ; Mousavi et al, 2019 ; Johnson et al, 2020 ; Yu et al, 2020 ; Dou et al, 2021 ), near-infrared (NIR) irradiation (808 nm, 1 W cm −2 ) was used to evaluate the PTT effect of the materials ( Figure 2A ). Initially, we observed rod-like morphology in the TEM images of P. aeruginosa .…”

Section: Resultsmentioning

confidence: 99%

Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles

et al. 2021

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Bacterial infection is a major threat to human health. However, many antibacterial agents currently used are severely limited due to drug-resistance, and the development of side effects. Herein, we have developed a non-antibiotic nanocomposite consisting of chitosan (ChS) coated silver nanoparticles (AgNPs) and graphene nanoribbon (GNR)-based nanowires for light-triggered eradication of bacteria. The presence of AgNP/ChS significantly enhanced the interactions of the GNR nanowires with Pseudomonas aeruginosa, a clinically common Gram-negative bacterium. Which enables the highly effective photothermal eradication of bacteria by GNR upon near-infrared light irradiation. The nanocomposite was shown to be applicable for the light-triggered eradication of bacterial biofilms and the inhibition of bacterial growth on medical patches used for abdominal-wall hernia surgery.

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Section: Resultsmentioning

confidence: 99%

Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles

et al. 2021

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“…Initially, mannosylated conjugated MUC1 generated both antitumor B and T cell responses in preclinical and clinical studies [241,242]. More recently, MMR-targeting was proposed for TAM modulation with siRNA [243] or DNA-based vaccines [244] to favour photothermal tumour therapy [245], or as carriers of chemotherapeutic drugs [246]. In particular, a recent study showed that mannose-functionalized nanoscaffolds as carriers of chemotherapeutic agents [247] efficiently killed tumours, although more in vivo studies are needed to confirm their efficiency.…”

Section: Taca and Clr Targeting For Cancer Immunotherapymentioning

confidence: 99%

Advances in the Immunomodulatory Properties of Glycoantigens in Cancer

Costa

Freire

2022

Cancers

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Aberrant glycosylation in tumour progression is currently a topic of main interest. Tumour-associated carbohydrate antigens (TACAs) are expressed in a wide variety of epithelial cancers, being both a diagnostic tool and a potential treatment target, as they have impact on patient outcome and disease progression. Glycans affect both tumour-cell biology properties as well as the antitumor immune response. It has been ascertained that TACAs affect cell migration, invasion and metastatic properties both when expressed by cancer cells or by their extracellular vesicles. On the other hand, tumour-associated glycans recognized by C-type lectin receptors in immune cells possess immunomodulatory properties which enable tumour growth and immune response evasion. Yet, much remains unknown, concerning mechanisms involved in deregulation of glycan synthesis and how this affects cell biology on a major level. This review summarises the main findings to date concerning how aberrant glycans influence tumour growth and immunity, their application in cancer treatment and spotlights of unanswered challenges remaining to be solved.

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“…Extensive efforts from the group of He have led to the development of receptor-targeting fluorescence imaging and theranostic systems using graphene oxide (GO) based supramolecular glycocomposites. (Ji et al, 2015;Dou et al, 2021). Many disease-related processes involve glycoligand-receptor interactions.…”

Section: Current State Of the Artmentioning

confidence: 99%

Fluorescent Chemosensors for Ion and Molecule Recognition: The Next Chapter

et al. 2021

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Over the past 30 years fluorescent chemosensors have evolved to incorporate many optical-based modalities and strategies. In this perspective we seek to highlight the current state of the art as well as provide our viewpoint on the most significant future challenges remaining in the area. To underscore current trends in the field and to facilitate understanding of the area, we provide the reader with appropriate contemporary examples. We then conclude with our thoughts on the most probable directions that chemosensor development will take in the not-too-distant future.

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Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy

Abstract: Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and...

Cited by 17 publications

References 55 publications

Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles

Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles

Advances in the Immunomodulatory Properties of Glycoantigens in Cancer

Fluorescent Chemosensors for Ion and Molecule Recognition: The Next Chapter

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