Graphene Oxide Coatings as Tools to Prevent Microbial Biofilm Formation on Medical Device

Cacaci, Margherita; Martini, Cécilia; Guarino, Cinzia; Torelli, Riccardo; Bugli, Francesca; Sanguinetti, Maurizio

doi:10.1007/5584_2019_434

Cited by 31 publications

(25 citation statements)

References 84 publications

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“…For instance, GMs have been investigated for the fabrication of antibacterial packages and protective clothing, for water treatment, as antifouling agents, and for the prevention of microbially influenced corrosion (MIC) ( Zheng et al., 2018 ; Wang et al., 2019a ; Bhattacharjee et al., 2019 ; Firouzjaei et al., 2020 ; Lu et al., 2019 ; Kumar et al., 2019 ; Krishnamurthy et al., 2013 ). Furthermore, a vast number of studies related to the medical field describe antibacterial materials containing Gr, GO, or rGO for several applications including wound dressing, tissue engineering, and drug delivery and for the prevention of biofilm formation on medical equipment and implantable devices ( Ji et al., 2016 ; Ramasamy and Lee, 2016 ; Cacaci et al., 2019 ; Hu et al., 2010 ).…”

Section: Applications For Negative Bacterial Interactions With Graphementioning

confidence: 99%

Graphene: An Antibacterial Agent or a Promoter of Bacterial Proliferation?

Zhang

Tremblay

2020

iScience

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Summary Graphene materials (GMs) are being investigated for multiple microbiological applications because of their unique physicochemical characteristics including high electrical conductivity, large specific surface area, and robust mechanical strength. In the last decade, studies on the interaction of GMs with bacterial cells appear conflicting. On one side, GMs have been developed to promote the proliferation of electroactive bacteria on the surface of electrodes in bioelectrochemical systems or to accelerate interspecies electron transfer during anaerobic digestion. On the other side, GMs with antibacterial properties have been synthesized to prevent biofilm formation on membranes for water treatment, on medical equipment, and on tissue engineering scaffolds. In this review, we discuss the mechanisms and factors determining the positive or negative impact of GMs on bacteria. Furthermore, we examine the bacterial growth-promoting and antibacterial applications of GMs and debate their practicability.

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Section: Applications For Negative Bacterial Interactions With Graphementioning

confidence: 99%

Graphene: An Antibacterial Agent or a Promoter of Bacterial Proliferation?

Zhang

Tremblay

2020

iScience

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“…GO represents a carbon nanomaterial that shows antibacterial activity either alone or in combination with other substances [10]. Few studies focused on the possibility to use GO as a coating to prevent bacterial adhesion [28][29][30] showing a reduction of adhesion and viability in the GO-functionalized samples compared to the control.…”

Section: Discussionmentioning

confidence: 99%

“…Particularly, GO, a precursor of large-scale graphene synthesis, has attracted attention for its multi-targeting killing strategy, simple production and low cost. Three main antimicrobial activities [10] have been reported:…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antibiofilm Properties of Graphene Oxide on Enterococcus faecalis

et al. 2020

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The aim of this study was to evaluate the antibacterial properties of graphene oxide (GO) against Enterococcus faecalis in vitro conditions and when used to coat dentin surface to prevent E. faecalis adhesion. The ATCC strain of E. faecalis 29212 has been used to perform a viability test. The pellet was suspended in ultrapure water, NaCl, PBS buffer, CaCl2 and MgCl2, Luria−Bertani broth solutions. The viability was evaluated by the colony forming unit counting method. Atomic force microscopy images and the measure of surface zeta potential variation were analyzed. Dentin discs were covered with a film of GO (n = 15) or were not treated (n = 15). Bacterial suspension was added to each sample of dentine discs and microbial counts were calculated. Statistically significant differences between two groups were assessed by a two-tailed unpaired t-test. Bacteria cell morphology was investigated with scanning electron microscopy. The highest growth inhibition was obtained in ddH2O and CaCl2 solution while, in PBS and NaCl, GO had poor antibacterial efficacy with a growth enhancing effect in the latter. GO on dentin discs demonstrated high antibacterial activity. GO film has demonstrated acceptable adhesion properties to root dentin and a role in the inhibition of bacterial film proliferation and biofilm formation.

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“…Utilizing two different proven antibacterial nanoparticles and two different matrix materials, researchers explore the physical properties of the novel nanocomposites and their effect on the manufacturing process. These nanoparticles are chosen due to their already current use in nanofilms and tools found in the healthcare industry [ 27 , 28 , 29 ]. These nanocomposites paired with AM allow for creating specialty parts and tools vital to the healthcare industry.…”

Section: Introductionmentioning

confidence: 99%

Utilization of Antibacterial Nanoparticles in Photocurable Additive Manufacturing of Advanced Composites for Improved Public Health

2021

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This paper presents the additive manufacturing and characterization of nanoparticle-reinforced photocurable resin-based nanocomposites with a potential antimicrobial function for improved public health applications. Two types of photocurable resins are reinforced by titanium dioxide (TiO2) or zinc oxide (ZnO) nanoparticles with average diameters in the 10–30 nm range to provide antimicrobial properties. The developed nanocomposites can be additively manufactured using the digital light processing method with an outstanding surface quality and precise geometrical accuracy. Experimental characterizations are conducted to investigate key mechanical properties of the 3D printed nanocomposites, including Young’s Modulus, tensile strength, and abrasion resistance. Specimens produced were observed to demonstrate the following characteristics during testing. Tensile strength increased by 42.2% at a maximum value of 29.53 MPa. The modulus of elasticity increased by 14.3%, and abrasion resistance increased by 15.8%. The proper dispersion of the nanoparticles within the cured resin is validated by scanning electron images. The wettability and water absorption testing results indicate that the developed nanocomposites have an outstanding water resistance capability. The pairing of digital light processing with these novel nanocomposites allows for the creation of complex composite geometries that are not capable through other manufacturing processes. Therefore, they have the potential for long-term usage to improve general public health with antimicrobial functionality. The pairing of an unmodified photocurable resin with a 1% ZnO concentration demonstrated the most promise for commercial applications.

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Graphene Oxide Coatings as Tools to Prevent Microbial Biofilm Formation on Medical Device

Cited by 31 publications

References 84 publications

Graphene: An Antibacterial Agent or a Promoter of Bacterial Proliferation?

Graphene: An Antibacterial Agent or a Promoter of Bacterial Proliferation?

Antimicrobial and Antibiofilm Properties of Graphene Oxide on Enterococcus faecalis

Utilization of Antibacterial Nanoparticles in Photocurable Additive Manufacturing of Advanced Composites for Improved Public Health

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