Graphene oxide nanoflakes prevent reperfusion injury of Langendorff isolated rat heart providing antioxidative activity in situ

Graphene Oxide Significantly Modifies Cardiac Parameters and Coronary Endothelial Reactivity in Healthy and Hypertensive Rat Hearts Ex Vivo

“…In the cited study, GO and rGO (proportionally to a reduction degree) increased the cellular ROS content and lowered the mitochondrial membrane potential, suggesting the mitochondrial origin of at least a part of the ROS level increase that was observed. Recently, the cardioprotective effects of the 10–15-layer GO and oxidized (C/O ratio of 2.5–2.6) with a flake size between 0.1 and 200 μm were reported by Voitko et al 62 In their data, the post-ischemic CFM significantly improved in the GO-pretreated group (a 32% increase in comparison with the control). The authors proposed that the protective effect could be mediated through an ROS scavenging mechanism and demonstrated its chemical origin.…”

“…In this study, to the best of our knowledge, the BSA-stabilized isotonic aqueous GO dispersions were intentionally used for the first time in the direct perfusion of the mammalian heart. Nonetheless, GO pretreatment was used in ischemia-reperfusion study protocol, 62 which led to an improvement in the coronary flow and reduction of the heart damage through free-radical scavenging mechanisms.…”