Graphene quantum dots for multiple biomedical applications

Winkless, Laurie

doi:10.1016/j.mattod.2015.11.024

Cited by 3 publications

(4 citation statements)

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“…The preparation of GBM-MNP hybrids involves the modification of graphene materials. There are two main strategies to derivatize GBMs: the covalent and the non-covalent approach [ 2c , 4 , 12 ]. In particular, covalent functionalization is the most frequently employed route to modify carbon materials, as this methodology yields products of high stability over time.…”

Section: Preparation Of Gbm-mnp Hybridsmentioning

confidence: 99%

“…The recent discovery of grapheme [ 1 ] has produced broad research attention to explore the possibilities of this new material in biomedical applications, mainly due to the characteristic structure and the extraordinary set of physicochemical properties [ 2 ]. Graphene is a single atomic layer of sp 2 carbon atoms arranged in a honeycomb lattice of nanometer dimensions.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances of Graphene-based Hybrids with Magnetic Nanoparticles for Biomedical Applications

Alegret

Criado

Prato

2017

CMC

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The utilization of graphene-based nanomaterials combined with magnetic nano-particles offers key benefits in the modern biomedicine. In this minireview, we focus on the most recent advances in hybrids of magnetic graphene derivatives for biomedical applica-tions. We initially analyze the several methodologies employed for the preparation of gra-phene-based composites with magnetic nanoparticles, more specifically the kind of linkage between the two components. In the last section, we focus on the biomedical applications where these magnetic-graphene hybrids are essential and pay special attention on how the addition of graphene improves the resulting devices in magnetic resonance imaging, con-trolled drug delivery, magnetic photothermal therapy and cellular separation and isolation. Finally, we highlight the use of these magnetic hybrids as multifunctional material that will lead to a next generation of theranostics.

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Section: Preparation Of Gbm-mnp Hybridsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances of Graphene-based Hybrids with Magnetic Nanoparticles for Biomedical Applications

Alegret

Criado

Prato

2017

CMC

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“…Graphene has unique two-dimensional structure and excellent physicochemical properties, which is the most promising nanomaterial in 21st century [ 1 , 2 ]. Graphene and its derivatives like graphene quantum dots (GQDs), graphene oxide (GO) and reduced graphene oxide (rGO) (so-called graphene-based nanomaterials, GBNMs) have been widely applied in biomedical fields due to the superior properties [ [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] ]. For example, GQDs exhibit excellent photoluminescence property [ 16 ], high photostability [ 17 ], and good biocompatibility [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Graphene-based nanomaterials for cancer therapy and anti-infections

Wang

et al. 2022

Bioactive Materials

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“…Carbon-based nanomaterials have emerged as an alternative to heavy metal semiconductor QDs. Carbon dots (CDs) exhibit tunable optical properties, while lacking the toxicity associated with heavy metals and semiconductors in biological systems ( Yang et al, 2009 ; Luo et al, 2014 ; Schroeder et al, 2016 ; Winkless, 2016 ; Iannazzo et al, 2017 ). These CDs consist of an amorphous carbon matrix core that consists of mainly sp3 hybridized carbons, but also contains sp2 domains and a passivated surface.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Synthesis of Carbon Dot – Iron Oxide Nanoparticles for Fluorescence Imaging and Therapy

Chung

Zhang

2021

Front. Bioeng. Biotechnol.

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Fluorescence microscopy is commonly used to image specific parts of a biological system, and is applicable for early diagnosis of cancer. Current fluorescent probes, such as organic dyes and quantum dots, suffer from poor solubility and high toxicity, respectively, demonstrating a need for a colloidal stable and non-toxic fluorescent probe. Here we present an iron oxide and carbon dot (CD) based nanoparticle (CNPCP) that displays optical properties similar to those of conventional fluorescent probe and also exhibits good biocompatibility. Fluorescent CDs were synthesized from glucosamine onto chitosan – polyethylene glycol (PEG) graft copolymer using microwave irradiation. These NPs were monodispersed in aqueous environments and displayed excitation-dependent fluorescence; they demonstrated good size stability and fluorescence intensity in biological media. In vitro evaluation of CNP as fluorescent probes in cancer cell lines showed that these NPs caused little toxicity, and allowed fast and quantitative imaging. Model therapeutic doxorubicin (DOX) was conjugated onto the NPs (CNPCP-DOX) to demonstrate the multifunctionality of the NPs, and in vitro studies showed that CNPCP-DOX was able to kill cancer cells in a dose dependent manner. These results indicate the potential of using CNPCPs as fluorescent probes capable of delivering chemotherapeutics.

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Graphene quantum dots for multiple biomedical applications

Cited by 3 publications

References 0 publications

Recent Advances of Graphene-based Hybrids with Magnetic Nanoparticles for Biomedical Applications

Recent Advances of Graphene-based Hybrids with Magnetic Nanoparticles for Biomedical Applications

Graphene-based nanomaterials for cancer therapy and anti-infections

Microwave-Assisted Synthesis of Carbon Dot – Iron Oxide Nanoparticles for Fluorescence Imaging and Therapy

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