Recent Advances of Graphene-based Hybrids with Magnetic Nanoparticles for Biomedical Applications

Abstract

The utilization of graphene-based nanomaterials combined with magnetic nano-particles offers key benefits in the modern biomedicine. In this minireview, we focus on the most recent advances in hybrids of magnetic graphene derivatives for biomedical applica-tions. We initially analyze the several methodologies employed for the preparation of gra-phene-based composites with magnetic nanoparticles, more specifically the kind of linkage between the two components. In the last section, we focus on the biomedical applications where these magnetic-graphene hybrids are essential and pay special attention on how the addition of graphene improves the resulting devices in magnetic resonance imaging, con-trolled drug delivery, magnetic photothermal therapy and cellular separation and isolation. Finally, we highlight the use of these magnetic hybrids as multifunctional material that will lead to a next generation of theranostics.

Synthesis, Optical, and Magnetic Properties of Graphene Quantum Dots and Iron Oxide Nanocomposites

“…Such novel hybrid NCs will be suitable for delivering nanocarriers to the tumor sites for imaging, whereas the NCs optical feature can be used as photothermal therapy agents to kill cancer cells efficiently [28][29][30]. erefore, the NCs offering both optical and magnetic capabilities may provide an interesting approach for the future medical treatments.…”

“…Moreover, the magnetic properties of Fe 3 O 4 nanoparticles make them an excellent contrast agent for MRI applications. However, the limitations of magnetic nanoparticles, including aggregation and precipitation inside the body vessels, can cause serious consequences [11]. As a solution, surface engineering of Fe 3 O 4 with GQDs was proposed to prevent aggregation and make applications more feasible.…”

Practical Solution for Effective Whole-Body Magnetic Fluid Hyperthermia Treatment

“…Thus, the present study proposes a shift from techniques based on static, steady, and equilibrium to unstable, dynamic, and nonequilibrium scenario, although other kinds of approaches using assistance of ultrasonic or photothermal hyperthermic effects have been discussed [24,25]. Therefore, the possibility of temporary heating of tumors was examined by pulsed irradiation using dynamically aligned structures of quasi-stable core-shell nanoparticles.…”

Potensi Nanokomposit Fe3O4@C dari Bijih Besi Sebagai Pendeteksi Kadar Glukosa

“…Nanopartikel magnetit juga memiliki sifat low toxicity [15], ramah lingkungan [16], dan biokompatibel sehingga dapat diaplikasikan sebagai drug delivery [15,17]. Selain memiliki banyak kelebihan, nanopartikel magnetit juga memiliki beberapa kekurangan yaitu mudah mengendap sehingga mengurangi efisiensi dan stabilitas dalam pembuluh darah [18], nanopartikel magnetit tanpa modifikasi juga mudah ter-aglomerasi (menggumpal) [7] dan tidak stabil terhadap asam dan basa [19]. Maka dari itu, untuk memperbaiki sifat stabilitas, mengurangi aglo-merasi, serta mengoptimalkan sifat adsorbsi-nya, modifikasi perlu dilakukan pada nanopartikel magnetit [20].…”

“…Nanokomposit magnetit karbon ini dapat meningkatkan kinerja adsorbsi sehingga sangat berpotensi menjadi adsorben magnetik untuk pengolahan air limbah [15], adsorben pewarna organik [20], adsorben pewarna tekstil serta memperbaiki sifat stabilitas kimia sehingga tidak mudah teroksidasi [19,24]. Nanopartikel magnetit yang dimodifikasi dengan karbon juga diketahui memiliki sifat adsorbsidesorpsi yang baik sehingga bisa diaplikasikan sebagai drug delivery [18,25].…”